Rifampicin News and Research

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New shorter treatment regimen found to be safer, more effective at treating drug-resistant TB

A new all-oral six-month treatment regimen is safer and more effective at treating rifampicin-resistant tuberculosis (RR-TB) than the current accepted standard of care, according to results announced at the 52nd Union World Conference on Lung Health.

20 Oct 2021

Weill Cornell receives NIH support to advance TB research

Tuberculosis (TB) is one of the deadliest infectious diseases in history and one of the few that naturally infects only humans.

4 Sep 2021

Designing effective multidrug-resistant-TB treatments based on DNA sequencing

Globally, tuberculosis is the most common bacterial infectious disease leading to death. The pathogen causing tuberculosis, Mycobacterium tuberculosis, has a number of peculiarities. One is that it is growing very slowly.

3 May 2021

Researchers find the right dosing of an old anti-tuberculosis drug

A considerably higher dose of the anti-tuberculosis drug rifampicin is safe and can also lead to a shorter treatment for tuberculosis and less resistance.

22 Mar 2021

Clofazimine inhibits coronaviruses including SARS-CoV-2, study finds

Researchers at the University of Hong Kong found that Clofazimine, a lipophilic antimicrobial riminophenazine dye used in combination with agents like rifampicin and dapsone to treat leprosy, inhibits coronaviruses, including the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19 disease.

21 Mar 2021

New drug cocktail offers hope to patients with highly drug-resistant tuberculosis

A new three-drug, all-oral, six-month treatment is providing hope to patients in Tajikistan with highly drug-resistant forms of tuberculosis, which until now had limited treatment options and poor prognosis.

3 Feb 2021

WHO revises definition of extensively drug-resistant tuberculosis

The definition of extensively drug-resistant tuberculosis (XDR-TB) has been revised by the World Health Organization's Global TB Programme, who have also defined pre-XDR-TB for the first time, highlighting the seriousness of these forms of TB.

1 Feb 2021

Overcoming pediatric drug-resistant TB crisis

World Children's Day marks the day, over three decades ago, on which world leaders adopted the historic Convention of the Rights of the Child, promising to every child to promote and protect their rights, including the right to life and the right to health.

30 Nov 2020

WHO welcomes SHINE trial results on shorter treatment for drug-susceptible TB in children

The World Health Organization's Global TB Programme welcomes the results from an important study on shortened treatment for drug-susceptible tuberculosis in children, presented at the 51st virtual Union World Conference on Lung Health.

2 Nov 2020

Countries should step-up leprosy prevention initiatives to accelerate decline in new cases

New cases of leprosy are decreasing, but not at the anticipated rate. In order to accelerate the annual decline, countries should screen contacts and treat eligible contacts with single-dose rifampicin, as recommended by the World Health Organization in its guidelines.

8 Sep 2020

WHO endorses Truenat molecular diagnostic tests for TB

The Foundation for Innovative New Diagnostics, Molbio Diagnostics and the Indian Council of Medical Research announced today that the World Health Organization has now endorsed three of their rapid molecular Truenat assays for initial diagnosis of tuberculosis (TB) and subsequent detection of rifampicin resistance in adults and children with signs and symptoms of pulmonary TB.

3 Jul 2020

New recommendations to tackle tuberculosis amid coronavirus crisis

The World Health Organization has today issued new recommendations to tackle tuberculosis, a respiratory disease, in the wake of coronavirus spreading across continents.

25 Mar 2020

Study shows superior functionality of Duodenum Intestine-Chip populated with organoids

Emulate, Inc. announced today a published study in collaboration with Johns Hopkins University School of Medicine, that demonstrated superior functionality of the Duodenum Intestine-Chip populated with organoids, compared to organoids alone.

14 Jan 2020

Software tool can predict how drugs can be combined to create effective treatments

With a shortage of new tuberculosis drugs in the pipeline, a software tool from the University of Michigan can predict how current drugs--including unlikely candidates--can be combined in new ways to create more effective treatments.

22 Nov 2019

Caution: blood infections traced to probiotics

Probiotics aren’t harmless, says a new study published on November 7, 2019 in the journal Nature Medicine. In fact, some patients may be put at serious risk by the bacteria in probiotics. Doctors should weigh the risks of probiotics in severely ill or immunocompromised patients before prescribing them, as their benefits may be significantly smaller than the danger in such situations.

13 Nov 2019

Cigarette smoke can make MRSA bacterium more resistant to antibiotics

Cigarette smoke can make MRSA bacterial strains more resistant to antibiotics, new research from the University of Bath has shown.

30 Jul 2019

New Cochrane Review updates guidelines on Xpert Ultra for diagnosing tuberculosis

Tuberculosis causes more deaths globally than any other infectious disease and is a top 10 cause of death worldwide.

11 Jun 2019

Virtual clinical trial: Improving methadone dosage for drug users with TB to prevent withdrawal symptoms

Drug users on methadone programs who contract tuberculosis should receive effective treatment while maintaining the correct level of methadone in their bodies, following a virtual clinical trial by pharmacy researchers at Aston University in partnership with drugs charity Addaction.

21 May 2019

Improved TB Diagnostic Assay for Better Multiplexing from Bruker

In time for the World Tuberculosis (TB) Day 2019 on Sunday, March 24th, Bruker today announced the launch of an important further innovation in the field of tuberculosis diagnostics.

From Bruker BioSpin - NMR, EPR and Imaging 26 Mar 2019

Anti-TB drugs can increase susceptibility to Mtb reinfection

Current treatments for tuberculosis are very effective in controlling TB infection caused by Mycobacterium tuberculosis. They don't, however, always prevent reinfection. Why this happens is one of the long-standing questions in TB research.

22 Mar 2019