SARS News and Research

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What does the future of clinical trials and evidence-based medicine look like?

In a recent perspective published in Nature Medicine, the researcher shared his vision and future perspectives for the domains of clinical research and evidence-based therapeutics.

18 Jan 2023

The efficacy of low-dose fluvoxamine compared with placebo for treating mild to moderate COVID-19 in the US

Researchers evaluated the efficacy of low-dosage fluvoxamine (50 mg two times a day) over 10 days in the management of mild and moderate-SARS-CoV-2 infections in the US.

18 Jan 2023

Upregulation of Robo4 expression reduces mortality from severe infection

The researchers screened a library of drugs using a mouse endothelial cell line to identify pathways that are involved in the regulation of Robo4 and found that two competitive SMAD signaling pathways appear to regulate Robo4 expression.

18 Jan 2023

Exploring a novel amplicon-based mpox virus sequencing strategy

Researchers described the development of a sequencing strategy based on amplicons for mpox detection.

18 Jan 2023

An in-depth meta-analysis highlights COVID-19's pregnancy dangers

Researchers assess the risk of maternal, fetal, and neonatal morbidity and mortality in women diagnosed with COVID-19 during pregnancy.

17 Jan 2023

Future COVID-19 control will require vaccines that induce better mucosal immunity

In a recent study posted to the medRxiv* preprint server, researchers in France explored the relationship between long-term immunoglobulin (Ig)-A response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and taste and smell disorders.

17 Jan 2023

On four flights out of China in December, 22% of passengers were SARS-CoV-2 positive

Researchers document COVID-19 screening results in Italy of 556 flight passengers from two Chinese provinces in late December 2022.

17 Jan 2023

What are the major findings of long COVID research?

Researchers explored existing literature on long coronavirus disease (COVID). They highlighted key immunological findings, similarities with other diseases, symptoms, and associated pathophysiological mechanisms, and diagnostic and therapeutic options, including COVID-19 vaccinations.

17 Jan 2023

Exploring bioinformatics approach for evaluating binding affinities of probable COVID-19 therapeutic decoys

Researchers developed a computational workflow based on molecular dynamic (MD) simulations and artificial neural network (ANN) to assess the SARS-CoV-2 spike (S) protein receptor-binding domain (RBD)-human angiotensin-converting enzyme 2 (hACE2) binding affinities of SARS-CoV-2 variants.

17 Jan 2023

S. aureus enhances replication of SARS-CoV-2 in vitro through the bacterial iron-regulated surface determinant protein A

Researchers assessed the impact of Staphylococcus aureus (S. aureus) on SARS-CoV-2 replication.

17 Jan 2023

COVID-19 is a threat during pregnancy, study suggests

Pregnant women who are infected with the virus that causes COVID-19 face a 7 times increased risk of dying and a significantly elevated risk of being admitted to an intensive care unit or suffering from pneumonia, according to research published today in BMJ Global Health.

17 Jan 2023

Could drinking tea help manage COVID-19?

Researchers summarized the content of active ingredients in different types of tea, the second most consumed beverage in the world. They also explored the possibility of using tea extracts for coronavirus disease 2019 (COVID-19) prevention and treatment.

17 Jan 2023

Researchers identify inhibitors of the SARS-CoV-2 Nsp14 N7-methyltransferase

A recent study identified inhibitors for SARS-CoV-2 non-structural protein 14 (Nsp14).

17 Jan 2023

Preclinical study shows the therapeutic value of kinetin against SARS-CoV-2

Researchers investigated the ability of kinetin (N6-furfurylaminopurine, MB-905) to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proliferation in vitro.

17 Jan 2023

The impact of cross-reactive immunity on the probability that a newly introduced SARS-CoV-2 variant will invade the host population

Researchers investigated the effect of cross-protective immunological responses on novel SARS-CoV-2 variant emergence by mathematical modeling.

17 Jan 2023

Study finds non-Omicron breakthrough infections elicit robust cross-neutralizing activity against Omicron variants across the antigenic barrier

Researchers assessed the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with a non-Omicron variant on SARS-CoV-2 BA.4/5 neutralization.

17 Jan 2023

SARS News and Research

What does the future of clinical trials and evidence-based medicine look like?

The efficacy of low-dose fluvoxamine compared with placebo for treating mild to moderate COVID-19 in the US

Upregulation of Robo4 expression reduces mortality from severe infection

Exploring a novel amplicon-based mpox virus sequencing strategy

An in-depth meta-analysis highlights COVID-19's pregnancy dangers

Future COVID-19 control will require vaccines that induce better mucosal immunity

On four flights out of China in December, 22% of passengers were SARS-CoV-2 positive

What are the major findings of long COVID research?

Exploring bioinformatics approach for evaluating binding affinities of probable COVID-19 therapeutic decoys

S. aureus enhances replication of SARS-CoV-2 in vitro through the bacterial iron-regulated surface determinant protein A

COVID-19 is a threat during pregnancy, study suggests

Could drinking tea help manage COVID-19?

Researchers identify inhibitors of the SARS-CoV-2 Nsp14 N7-methyltransferase

Preclinical study shows the therapeutic value of kinetin against SARS-CoV-2

The impact of cross-reactive immunity on the probability that a newly introduced SARS-CoV-2 variant will invade the host population

Study finds non-Omicron breakthrough infections elicit robust cross-neutralizing activity against Omicron variants across the antigenic barrier

Overall patterns of SARS-CoV-2 caused by variants of concern among children and adolescents

Endothelial cell-specific protein Robo4 reduces mortality in severe infection

Mucosal IgA antibodies in the airways protect against SARS-CoV-2 infection for at least eight months

New test 'fishes' for multiple respiratory viruses using DNA as 'bait'

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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