Selective Serotonin Reuptake Inhibitor (SSRI) News and Research

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Selective Serotonin Reuptake Inhibitor (SSRI) is a type of drug that is used to treat depression. SSRIs slow the process by which serotonin (a substance that nerves use to send messages to one another) is reused by nerve cells that make it. This increases the amount of serotonin available for stimulating other nerves. Also called selective serotonin reuptake inhibitor.

Drug company disputes claim of new study on antidepressant Paxil

Drug company GlaxoSmithKline (GSK) is disputing claims that its antidepressant Paxil was linked to an increased suicide risk in adults.

23 Aug 2005

Antidepressant drug should have suicide warning for adults as well as children

According to a Norwegian study, adults taking the antidepressant drug paroxetine are at a higher risk of attempting to commit suicide than those not taking medication.

22 Aug 2005

Paroxetine linked to higher rate of suicide

Adult patients taking the antidepressant drug paroxetine are at higher risk of attempting to commit suicide than those not taking medication.

22 Aug 2005

Multiple rare mutations within a single gene may increase risk for autism

While debate still rages over the 'cause' of autism, mounting evidence suggests that genetic factors play a major role in the disease.

25 Jul 2005

Older-style antidepressants, as well as anticonvulsant drugs, can help ease the disabling pain caused by nerve tissue damage

For many years antidepressants, which are believed to work by dampening pain signals, have been the first-line drugs for neuropathic pain. "It is usual to start with an antidepressant like amitriptyline, and if this fails then try an anticonvulsant," says Phil Wiffen, a researcher at Churchill Hospital in Oxford, England. "The results of these meta-analyses suggest this is probably still the best approach to take."

19 Jul 2005

Current recommendations for prescribing antidepressants should be reconsidered

Most people with depression are initially treated with antidepressants, and prescribing has risen by 253% in 10 years. Yet recent studies show that SSRIs have no clinically meaningful advantage over placebo, write Joanna Moncrieff and Irving Kirsch.

14 Jul 2005

Increase in heart surgery mortality from SSRIs or depression?

Duke University Medical Center researchers have found that patients who were using a class of anti-depression drugs known as selective serotonin reuptake inhibitors (SSRI) prior to undergoing coronary artery bypass surgery have significantly higher death and rehospitalization rates up to five years after the procedure than patients who were not on SSRIs.

26 May 2005

Use of a common type of antidepressant may increase gastrointestinal (GI) bleeding

In fact, the study suggests that the increase is similar to that associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs, known as pain relievers). DDW is the largest international gathering of physicians, academics and researchers in the fields of gastroenterology, hepatology, endoscopy and gastrointestinal surgery.

17 May 2005

St. John's Wort only minimally effective in relieving major depression

St. John’s Wort, the herbal medicinal long thought to relieve symptoms of depression, provides only minor benefits in patients with the most acute depression and perhaps no benefit for those with chronic depression.

16 May 2005

EU calls for tougher warnings on antidepressants for kids

A committee of experts in Europe are calling for strong warnings to be placed on two classes of antidepressants, informing doctors and parents of the risk they could pose to children and adolescents.

25 Apr 2005

Study may lead to a better understanding of how antidepressants like Prozac work

According to results published in today's issue of the journal Neuron, a study in mice proposes that dopamine and serotonin neurotransmitter systems in the brain occasionally get their signals crossed, causing delays in stabilizing mood.

7 Apr 2005

SSRI antidepressants "hijack" dopamine signaling as well launching serotonin signals

Researchers have discovered that antidepressant drugs such as Prozac not only affect levels of the neurotransmitter serotonin in the brain, but also "hijack" dopamine signaling as well--causing it to launch serotonin signals. Their findings offer new insight into how Prozac and other "selective serotonin uptake inhibitors" (SSRIs) work and how they might cause problems in patients taking them.

6 Apr 2005

Antidepressants not the culprit in depression linked to heart attacks

The increased risk of heart attack associated with taking antidepressants may be caused by the depression itself rather than the drugs themselves, suggests new research reported in the current issue in the British Medical Journal. At least one in 10 older people are prescribed antidepressants.

15 Mar 2005

Second-generation Antidepressants

A recent article in the prestigious British Medical Journal seems to confirm an increased risk for suicidal behavior among adults taking popular antidepressants. This follows evidence that certain selective serotonin reuptake inhibitors (SSRIs) may have a similar effect among children and adolescents.

27 Feb 2005

Antidepressant drugs may be associated with an increased risk of suicidal behaviour

Antidepressant drugs may be associated with an increased risk of suicidal behaviour, particularly in the early stages of treatment, shows new evidence in this week's BMJ.

20 Feb 2005

American suicide rates have dropped steadily since the introduction of serotonin reuptake inhibitor (SSRI) drugs

Challenging recent claims linking antidepressant use to suicidal behavior, a new UCLA study shows that American suicide rates have dropped steadily since the introduction of Prozac and other serotonin reuptake inhibitor (SSRI) drugs.

3 Feb 2005

More data needed on what's effective for hot flashes

A University of Michigan expert on menopause says a new study that indicates placebos work as well as antidepressant drugs to help hot flashes shows how much more research is needed about what gives patients relief.

17 Jan 2005

Mutant gene that starves the brain of serotonin 10 times more prevalent in depressed patients

A mutant gene that starves the brain of serotonin, a mood-regulating chemical messenger, has been discovered and found to be 10 times more prevalent in depressed patients than in control subjects, report researchers funded by the National Institutes of Health’s National Institute of Mental Health (NIMH) and National Heart Lung and Blood Institute (NHLBI).

21 Dec 2004

Newly discovered genetic defect might represent an important risk factor for major depression

A newly discovered genetic defect might represent an important risk factor for major depression, a condition which effects 20 million people in the U.S., according to Duke University Medical Center researchers.

13 Dec 2004

Review findings released on the safety of antidepressants (SSRI's)

The Medicines and Healthcare products Regulatory Agency (MHRA) issued new advice to patients and doctors about the group of antidepressants known as SSRI's, today.

6 Dec 2004