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Rethinking the germ theory: A balanced take on microbes and disease outcomes

Review explores the complexities of infectious disease outcomes through a balanced perspective, emphasizing the interplay between pathogenic microbes and host conditions, challenging the traditional germ-disease theory by proposing a more integrated view that considers both pathogen virulence and host immunity's impact on disease manifestation.

10 Apr 2024

Scientists identify distinct molecular signatures for sepsis diagnosis and prognosis

Researchers from Lund University in Sweden have identified distinct molecular signatures associated with the clinical signs of sepsis that could provide more accurate diagnosis and prognosis of sepsis, as well as help to target specific therapies at patients who would benefit most, according to new research being presented at this year's European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2024) in Barcelona, Spain (27-30 April).

30 Mar 2024

Heart at risk from ARDS: Inflammatory responses fuel cardiovascular complications

Research highlights the inflammatory impacts of ARDS on the heart, underscoring the role of immune responses in cardiovascular complications from viral infections, including COVID-19, and emphasizes the potential of TNF-α neutralizing therapy to mitigate these effects.

24 Mar 2024

Kefir shows promise in improving gut health of ICU patients, study finds

The safety, feasibility, and impact of kefir administration on the gut microbiome of critically ill adults.

28 Feb 2024

Digital DNA melting analysis can be a faster and more reliable tool for pathogen detection

A new analysis method can detect pathogens in blood samples faster and more accurately than blood cultures, which are the current state of the art for infection diagnosis.

21 Feb 2024

Updated pediatric sepsis definition could save countless children's lives

An international research team led by Tell Bennett, MD, MS, professor of biomedical informatics and pediatric critical care at the University of Colorado School of Medicine, released new diagnostic criteria for sepsis in children this week, marking the first update to the pediatric sepsis definition in nearly two decades.

22 Jan 2024

New study reveals key blood markers for sepsis diagnosis in burn patients

The efficacy of Complete Blood Count (CBC) parameters in diagnosing sepsis.

10 Jan 2024

Three cytokine pairs found to be responsible for the body's damaging response to sepsis

Sepsis -; when an infection causes the immune system to improperly target the body -; is one of the leading causes of death in the ICU.

8 Jan 2024

Phase I clinical trial of new CAR T cell therapy AT101 shows promising early responses

Early results from a Phase I clinical trial of AT101, a new CAR T cell therapy that uses a distinct binding mechanism to target CD19, show a 100 percent complete response (CR) rate at the higher dose levels studied in the trial, according to researchers from the University of Pennsylvania Perelman School of Medicine and Penn Medicine's Abramson Cancer Center.

11 Dec 2023

BMI should not be used to determine eligibility for gender-affirming chest surgery

Body mass index, or BMI, is a person's mass (weight) in kilograms divided by the square of their height in meters.

7 Nov 2023

Is there an association between vitamin D deficiency and sepsis mortality?

The impact of deficient serum vitamin D levels on sepsis prognosis.

12 Oct 2023

Feds hope to cut sepsis deaths by hitching Medicare payments to treatment stats

Don Smith remembers the moment he awoke in an intensive care unit after 13 days in a medically induced coma. His wife and daughter were at his bedside, and he thought it had been only a day since he arrived at the emergency room with foot pain.

11 Oct 2023

Patients with heart conditions should practice good hygiene to prevent infective endocarditis

Patients with specific cardiac conditions such as valvular heart disease and congenital abnormalities, or those requiring a pacemaker, should practice good dental and skin hygiene to help prevent rare but potentially deadly infections of the heart's inner lining and valves, according to European Society of Cardiology (ESC) Guidelines on infective endocarditis, published online today in European Heart Journal.

25 Aug 2023

STING gene variant linked to increased risk of severe group A strep infections

Group A streptococci are fairly common bacteria that can cause, among other things, strep throat or impetigo.

17 Aug 2023

Role of M2 macrophage-derived exosomes in controlling neutrophil-mediated tissue injury in sepsis

Researchers investigate whether M2 macrophage-derived exosomes could prevent inflammation-associated damage during sepsis.

7 Aug 2023

Study reports the first protein-based diagnostic signature to discriminate MIS-C from Kawasaki Disease and other common infections

Researchers explore the distinguishing features of MIS-C as compared to other inflammatory-infectious syndromes in children.

4 Aug 2023

Septic Shock News and Research

Rethinking the germ theory: A balanced take on microbes and disease outcomes

Scientists identify distinct molecular signatures for sepsis diagnosis and prognosis

Heart at risk from ARDS: Inflammatory responses fuel cardiovascular complications

Kefir shows promise in improving gut health of ICU patients, study finds

Digital DNA melting analysis can be a faster and more reliable tool for pathogen detection

Updated pediatric sepsis definition could save countless children's lives

New study reveals key blood markers for sepsis diagnosis in burn patients

Three cytokine pairs found to be responsible for the body's damaging response to sepsis

Phase I clinical trial of new CAR T cell therapy AT101 shows promising early responses

BMI should not be used to determine eligibility for gender-affirming chest surgery

Is there an association between vitamin D deficiency and sepsis mortality?

Feds hope to cut sepsis deaths by hitching Medicare payments to treatment stats

Patients with heart conditions should practice good hygiene to prevent infective endocarditis

STING gene variant linked to increased risk of severe group A strep infections

Role of M2 macrophage-derived exosomes in controlling neutrophil-mediated tissue injury in sepsis

Study reports the first protein-based diagnostic signature to discriminate MIS-C from Kawasaki Disease and other common infections

Study shows that COVID-19 patients presented different plasma trace elements levels depending on disease severity

COVID-19 treatment: study evaluates ACEi and ARB effects on clinical outcomes

Will a ‘national patient safety board,’ modeled after the NTSB, actually fly?

The clinical and virological characteristics of severe neonatal echovirus 11 infections

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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