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Study finds metabolic checkpoint PHGDH as potential target to modulate tumor-associated macrophages

A study by a scientific team from the University of Vienna and the MedUni Vienna, recently published in the top-class journal Cellular & Molecular Immunology, has a promising result from tumor research: The enzyme phosphoglycerate dehydrogenase (PHDGH) acts as a metabolic checkpoint in the function of tumor-associated macrophages (TAMs) and thus on tumor growth.

27 Feb 2024

Advanced melanoma survival rates improve significantly from 2013 to 2019, Dutch study finds

The change in overall survival (OS) among advanced melanoma patients diagnosed between 2013 and 2021.

14 Feb 2024

COVID-19's lasting impact on smell and brain health unveiled

Study reviews the impact of COVID-19 on olfactory dysfunction and its link to neurocognitive disorders, highlighting MRI findings and potential treatments for smell loss.

12 Feb 2024

Study reveals role of protein modification in neurodegenerative disease progression

Neurodegenerative diseases, such as Alzheimer's and Parkinson's, present a significant health challenge, affecting over 50 million people globally.

12 Feb 2024

Paxlovid enhances treatment options for COVID-19 patients

The design, synthesis, and mechanism of action of Paxlovid.

6 Feb 2024

Study addresses knowledge gap of clinical features and outcomes of Black patients with melanoma

Researchers identified patient- and tumor-level melanoma features in black individuals.

25 Jan 2024

Persistent presence of SARS-CoV-2 RNA found in long COVID patients

Researchers conduct blood digital transcriptomics to determine the persistence of SARS-CoV-2 RNA in patients with long COVID-19.

23 Jan 2024

Study shows Omicron variants evade immune system like predecessors, suggesting key evolutionary trait in SARS-CoV-2

Researchers compared SARS-CoV-2 Omicron variant of concern replication in human cell lines and primary airway cultures and measured host responses to infection.

19 Jan 2024

JN.1 variant's spread not due to enhanced immune escape, study suggests

Study finds the JN.1 variant of SARS-CoV-2 may not have increased immune escape ability compared to its predecessor BA.2.86, suggesting other factors for its rapid spread.

14 Jan 2024

Protein linked to neurodegeneration turns out to be crucial for healthy brain function

Researchers have discovered that a protein called phosphorylated α-synuclein, which is associated with several neurodegenerative diseases such as Parkinson's disease and Lewy body dementia, is also involved in the normal processes of how neurons communicate with each other in a healthy brain.

9 Jan 2024

Key role of ion and water influx in T cell migration uncovered

Research reveals that T cell migration relies on ion and water influx for actin polymerization and movement, with the WNK1 kinase playing a critical role in regulating these processes, offering new insights into adaptive immunity.

10 Dec 2023

New insights into how SARS-CoV-2 evades our immune system

This review in Cellular and Molecular Immunology delves into the innate immune response to SARS-CoV-2, exploring how the virus evades immunity and the potential role of innate immunity in long-COVID and vaccine responses, shedding light on future therapeutic strategies.

23 Nov 2023

Microautophagy plays crucial role in lysosome repair, promoting healthy aging

To age or not to age! How does aging affect organisms on a cellular level? What mechanisms help cells survive self-inflicted or external harm? It is known that lysosomes-;critically important cellular structures-;are crucial for digesting damaged cellular components and pathogens, and maintain stability within cells and tissues.

21 Nov 2023

Coffee and COVID: Study finds coffee inhibits SARS-CoV-2, offers new dietary defense strategy

Study discovers that coffee, especially its bioactive compounds like chlorogenic acids, can inhibit SARS-CoV-2 entry and reduce ACE2 and TMPRSS2 levels, indicating that coffee intake might be a potential dietary strategy for COVID-19 prevention.

16 Nov 2023

Pioneering study finds predictive biomarker in lung adenocarcinoma

The potential of the transcriptome of tumor-adjacent normal lung tissue in predicting the prognosis of lung cancer.

13 Nov 2023

Receptor structure-based virtual screening identifies a promising p38α inhibitor

Announcing a new publication for Acta Materia Medica journal. Mitogen-activated protein kinases (MAPKs) are a group of serine-threonine protein kinases that can be activated by extracellular stimuli.

27 Oct 2023

COVID-19 tied to elevated risk of benign prostatic hyperplasia complications

SARS-CoV-2 infection linked to increased benign prostatic hyperplasia (BPH) complications and medication use. Urological manifestations in COVID-19 patients emphasize the importance of awareness among clinicians.

22 Oct 2023

Discovery of a novel therapeutic target for pancreatic cancer

A novel amino acid transporter-based therapeutic target for pancreatic ductal adenocarcinoma (PDAC).

10 Oct 2023

Research opens the door for better use of people's own immune system T cells to fight cancer

Using laboratory-grown cells from humans and genetically engineered mice, scientists at Johns Hopkins Medicine say they have evidence that modifying a specific protein in immune white blood cells known as CD8+ T cells can make the cells more robust, potentially opening the door for better use of people's own immune system T cells to fight cancer.

3 Oct 2023

The power of nanobodies: How they impact COVID-19 immune response

The structures of 340 antibodies (Abs) and 83 nanobodies.

25 Sep 2023