Severe Acute Respiratory News and Research

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Simulating transmission dynamics of SARS-CoV-2 Omicron variant

Researchers simulated the emergence of Omicron, a novel SARS-CoV-2 VOC, in a general European setting using an individual-based transmission model.

17 Dec 2021

Predicting local surges of COVID-19 hospitalizations in 2022

Researchers have identified simple and easy-to-communicate decision rules to provide early warnings - when a pre-specified threshold of hospital capacity will likely be exceeded within a four or eight week period.

17 Dec 2021

Modeling the potential interaction between COVID-19 outbreaks in susceptible and vaccinated sub-populations

Researchers demonstrated that the combination of infection of remaining susceptible individuals and breakthrough infections of vaccinated individuals promotes infection by invading variants.

17 Dec 2021

Vaccine effectiveness against COVID-19 caused by Omicron and Delta SARS-CoV-2 variants in England

Researchers performed a test-negative case-control study to determine the effectiveness of BNT162b2 and ChAdOx1 COVID-19 vaccines against the Omicron and Delta variants of SARS-CoV-2.

17 Dec 2021

Effectiveness of COVID-19 vaccines among older male veterans

A new research letter assessed the effectiveness of the mRNA1273 and BNT162b2 vaccines among fully vaccinated male veterans who were 65 years of age or above from July to September 2021.

17 Dec 2021

Primary responses to SARS-CoV-2 in COVID-19 naïve vaccinees

Researchers evaluated primary responses in SARS-CoV-2-naïve vaccinees, as well as secondary responses in the SARS-CoV-2-infected vaccines, and observed a clear set of differences in their clinical symptoms, antibody levels, and cellular and mucosal immune responses.

17 Dec 2021

Identifying protein targets in SARS-CoV-2 via machine learning

A new study provides insight on using an ML-based algorithm to analyze and predict therapeutic targets in emerging pathogens with a range of mutations.

17 Dec 2021

Impact of SARS-CoV-2 Omicron mutations on the use of therapeutic antibodies in COVID-19 treatment

Researchers investigated the mutations reported in the Omicron variant and its likely impact on the use of therapeutic antibodies in COVID-19 treatment as well as on vaccinated individuals.

17 Dec 2021

Investigating SARS-CoV-2 genomics-informed outbreaks using new bioinformatics tools

Researchers have created a tool designed to make as much use of the overwhelming amount of SARS-CoV-2 data as possible.

17 Dec 2021

Prediction of waning COVID-19 vaccine efficacy against Omicron variant

Researchers performed a meta-analysis of the results of four previous studies estimating fold-drop in neutralization titer against Omicron to present a combined estimate of the same.

17 Dec 2021

Analysis of the alteration of neutralizing titers with Omicron pseudovirus

A new study measured antibody levels from blood samples of vaccinated individuals and individuals who recovered from COVID-19 illness.

17 Dec 2021

Comparison of RBD/ACE2 receptor complex in wild type SARS-CoV-2 and Omicron variant

New research details the molecular landscape of Omicron’s RBD and how it differs from the original SARS-CoV-2 strain.

17 Dec 2021

New study demonstrates SARS-CoV-2 Omicron antibody escape

A new study examined the neutralization of virus variants using three sets of antibodies: serum from individuals vaccinated or infected with earlier variants of the virus; concentrated human antibodies from plasma donors; and approved monoclonal antibodies.

16 Dec 2021

Moderna booster vaccination overcomes SARS-CoV-2 Omicron variant antibody escape

A new study reports the results of a study focused on immune evasion characteristics, specifically the ability to escape neutralization by antibodies to the earlier SARS-CoV-2 variants or to the spike antigen used in COVID-19 vaccines.

16 Dec 2021

Study suggests convalescent plasma appears safe but does not prevent SARS-CoV-2 infection

A new study assesses the safety and efficacy of SARS-CoV-2 convalescent plasma containing high titers of anti-SARS-CoV-2 antibodies as PEP.

16 Dec 2021

Therapeutic antibodies deemed ineffective against Omicron variant of SARS-CoV-2

A new study found that the Omicron S protein evades antibodies with a 44-fold higher efficiency than the Delta variant's spike, rendering therapeutic antibodies ineffective and likely negatively impacting antibody protection induced by infection or double vaccination.

16 Dec 2021

Severe Acute Respiratory News and Research

Simulating transmission dynamics of SARS-CoV-2 Omicron variant

Predicting local surges of COVID-19 hospitalizations in 2022

Modeling the potential interaction between COVID-19 outbreaks in susceptible and vaccinated sub-populations

Vaccine effectiveness against COVID-19 caused by Omicron and Delta SARS-CoV-2 variants in England

Effectiveness of COVID-19 vaccines among older male veterans

Primary responses to SARS-CoV-2 in COVID-19 naïve vaccinees

Identifying protein targets in SARS-CoV-2 via machine learning

Impact of SARS-CoV-2 Omicron mutations on the use of therapeutic antibodies in COVID-19 treatment

Investigating SARS-CoV-2 genomics-informed outbreaks using new bioinformatics tools

Prediction of waning COVID-19 vaccine efficacy against Omicron variant

Analysis of the alteration of neutralizing titers with Omicron pseudovirus

Comparison of RBD/ACE2 receptor complex in wild type SARS-CoV-2 and Omicron variant

New study demonstrates SARS-CoV-2 Omicron antibody escape

Moderna booster vaccination overcomes SARS-CoV-2 Omicron variant antibody escape

Study suggests convalescent plasma appears safe but does not prevent SARS-CoV-2 infection

Therapeutic antibodies deemed ineffective against Omicron variant of SARS-CoV-2

Capability of BNT162b2 vaccine given in 2 or 3 doses to neutralize SARS-CoV-2 Omicron

T cell responses remain broadly robust against Omicron variant of SARS-CoV-2

Neutralization potency of COVID-19 vaccine boosters against SARS-CoV-2 variant pseudoviruses

Human monoclonal antibody protects against SARS-CoV-2 and SARS-CoV in vivo

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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