Severe Acute Respiratory News and Research

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Neutralizing antibodies to SARS-CoV-2 in mice depend on Fc effector function

A new study reports the essential nature of Fc-mediated functionalities in determining the efficacy of such antibodies.

24 Mar 2021

New covalent and non-covalent SARS-CoV-2 inhibitors discovered in silico

A new study describes the use of a combination of virtual and experimental screening protocols to identify potential inhibitors of the virus, which could lead to rapid drug development.

24 Mar 2021

Epitope antibody testing is effective in detecting immune responses to SARS-CoV-2

A new preprint study led by Shawn S-C. Li from Western University in Ontario, Canada, provides evidence of epitope-specific antibody responses and designed a test to measure this in relation to disease severity and outcome after infection.

24 Mar 2021

Research suggests toothpaste and mouthwash ingredients could help prevent SARS-CoV-2 infection

Now, new research published on the bioRxiv preprint server focuses on the effect of some typical ingredients present in commercially available mouthwashes and toothpaste on the mechanisms of SARS-CoV-2 entry into host cells.

24 Mar 2021

Potent nanobody binds SARS-CoV-2 spike in an extraordinary manner

In a new study, published recently on the bioRxiv preprint server, researchers isolated a nanobody that potently neutralizes SARS-CoV-2, including the B.1.351 variant, and cross-neutralizes SARS-CoV. They demonstrated the therapeutic potential of the nanobody in a human ACE2 (angiotensin-converting enzyme) transgenic mouse model.

24 Mar 2021

CureVac's COVID-19 vaccine protects mice against emerging SARS-CoV-2 variants

The CVnCoV mRNA vaccine showed neutralizing antibody levels and completely protected mice infected with the B.1.351 variant. No viral genomes were seen in oral swabs, lungs, or brain.

23 Mar 2021

Study shows single dose of mRNA vaccine may suffice for those with prior SARS-CoV-2 infection

A recent study by researchers from Philadelphia, currently available on the medRxiv preprint server, shows that individuals with prior infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibit substantial immune memory and develop a robust response to the first dose of an mRNA vaccine.

23 Mar 2021

Is T-cell receptor sequencing a reliable alternative to SARS-CoV-2 antibody testing?

Researchers in the United States have now demonstrated that T-cell receptor (TCR) sequencing might provide a reliable alternative to assessing infection in convalescent blood plasma, and may be applicable in the future for applying protective immunity to individuals.

23 Mar 2021

Correlation of antibody titers with COVID-19 vaccine efficacy

In a new study the relationship between virus-neutralizing antibody and spike protein-binding IgG antibody levels is explored following vaccination by one of seven currently deployed vaccines. The findings support the use of antibody titers as correlates of protection for COVID-19 vaccines.

23 Mar 2021

Immunoassay heterogeneity and implications for SARS-CoV-2 serosurveillance

In a recent study, scientists have quantified anti-SARS-CoV-2 antibody levels up to 9 months after infection.

23 Mar 2021

A new COVID-19 candidate vaccine induces robust humoral and cellular immune responses in mice

A Korea-based company EyeGene Inc. has recently developed a liposome-based mRNA candidate vaccine against COVID-19, which contains full-length spike protein of the European variant (D614G) of SARS-CoV-2 as a vaccine antigen.

23 Mar 2021

COVID-19 antibodies can protect against reinfection for at least eight months

A new study offers hope that recovered patients from COVID-19 are largely immune to reinfection for at least eight months.

23 Mar 2021

Study suggests SARS-CoV-2 antibodies in breast milk are robust, neutralizing and durable

A new study addresses the issue of passive immunity to SARS-CoV-2 for newborns via breast milk.

23 Mar 2021

Dandelion extract inhibits SARS-CoV-2 in vitro

An exciting new study describes a specific inhibitor of the SARS-CoV-2 found in an extract of the common dandelion that could provide a new and fruitful avenue of drug research.

23 Mar 2021

IONTAS identifies novel SARS-CoV-2 neutralising antibodies

IONTAS Limited (IONTAS) and FairJourney Biologics S.A (FJB)., leaders in the discovery and optimization of fully human antibodies, have announced the identification of neutralizing antibodies, which bind to multiple emerging SARS-CoV-2 variants.

From FairJourney Biologics 23 Mar 2021

Ai helps identify critical interactions for SARS-CoV-2 spike protein binding to ACE2

Recently, researchers from the US employed multiple-µs molecular dynamic simulations to compare the relative dynamics, stabilities, and energy differences between the SARS-CoV receptor-binding domain (RBD)-ACE2 and SARS-CoV-2 RBD-ACE2 complexes. The study is published on the preprint server, bioRxiv.

23 Mar 2021

Swiss research shows clusters of SARS-CoV-2 infection are rare within school classes

Researchers from Switzerland recently presented the results of a longitudinal cohort study they conducted in the city of Zurich. The prospective cohort study's key objective was to analyze the longitudinal changes in SARS-CoV-2 seroprevalence and assess the clustering of seropositive children in school classes from June to November 2020 in Zurich, Switzerland.

23 Mar 2021

Single BNT162b2 mRNA dose induces humoral and T cell responses against mutated variants with a history of COVID-19

In a paper recently uploaded to the preprint server bioRxiv by Tauzin et al. (March 18th, 2021) the ability of a single dose of mRNA vaccine to induce humoral and T cell responses against mutated variants are demonstrated and found to be reinforced in individuals with a history of COVID-19.

22 Mar 2021

Simple SARS-CoV-2 mutations allow escape from the majority of polyclonal antibodies

The group identified a single class of antibodies that target a particular epitope on the RBD of SARS-CoV-2, suggesting that the human polyclonal response to SARS-CoV-2 infection is dominated by a worryingly narrow range of antibodies that target an epitope undergoing rapid mutation.

22 Mar 2021

Survey of smokers and vapers in the U.S. during COVID

Researchers at the Massachusetts General Hospital aimed to understand the changes in cigarette and e-cigarette use behaviors among adults in the United States. They found that a third of cigarette smokers and a quarter of vape or e-cigarette users increased their use during the pandemic, mainly due to stress.

22 Mar 2021

Severe Acute Respiratory News and Research

Neutralizing antibodies to SARS-CoV-2 in mice depend on Fc effector function

New covalent and non-covalent SARS-CoV-2 inhibitors discovered in silico

Epitope antibody testing is effective in detecting immune responses to SARS-CoV-2

Research suggests toothpaste and mouthwash ingredients could help prevent SARS-CoV-2 infection

Potent nanobody binds SARS-CoV-2 spike in an extraordinary manner

CureVac's COVID-19 vaccine protects mice against emerging SARS-CoV-2 variants

Study shows single dose of mRNA vaccine may suffice for those with prior SARS-CoV-2 infection

Is T-cell receptor sequencing a reliable alternative to SARS-CoV-2 antibody testing?

Correlation of antibody titers with COVID-19 vaccine efficacy

Immunoassay heterogeneity and implications for SARS-CoV-2 serosurveillance

A new COVID-19 candidate vaccine induces robust humoral and cellular immune responses in mice

COVID-19 antibodies can protect against reinfection for at least eight months

Study suggests SARS-CoV-2 antibodies in breast milk are robust, neutralizing and durable

Dandelion extract inhibits SARS-CoV-2 in vitro

IONTAS identifies novel SARS-CoV-2 neutralising antibodies

Ai helps identify critical interactions for SARS-CoV-2 spike protein binding to ACE2

Swiss research shows clusters of SARS-CoV-2 infection are rare within school classes

Single BNT162b2 mRNA dose induces humoral and T cell responses against mutated variants with a history of COVID-19

Simple SARS-CoV-2 mutations allow escape from the majority of polyclonal antibodies

Survey of smokers and vapers in the U.S. during COVID

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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