Signaling Pathway News and Research

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TOR signaling and dietary restriction

University of Washington scientists have uncovered details about the mechanisms through which dietary restriction slows the aging process.

17 Apr 2008

Lipitor and Celebrex combined may halt prostate cancer

Researchers at Rutgers' Ernest Mario School of Pharmacy have shown that administering a combination of the widely used drugs Celebrex (celecoxib, a nonsteroidal anti-inflammatory drug) and Lipitor (atorvastatin, a cholesterol lowering drug) stops the transition of early prostate cancer to its more aggressive and potentially fatal stage.

15 Apr 2008

Brain study may lead to improved epilepsy treatments

Using a rodent model of epilepsy, researchers found one of the body's own neurotransmitters released during seizures, glutamate, turns on a signaling pathway in the brain that increases production of a protein that could reduce medication entry into the brain.

15 Apr 2008

Researchers study Rituximab's action on cancer stem cells

Preliminary data from one of the first clinical trials to test a stem cell-targeting drug in cancer patients shows that while the drug did not prolong survival, its suppressing effect on patients' stem cells was impressive enough to send investigators looking for a better drug to try.

13 Apr 2008

Developing cancer treatments directed at critical developmental pathway

Researchers from the University of Pennsylvania School of Medicine and colleagues discovered that the Notch signaling pathway, which determines the development of many cell types, and is also implicated in some cancers, is not universally essential for the maintenance of stem cells.

11 Apr 2008

New understanding of cancer stem cells

By revealing the inner workings of a common cell-to-cell signaling system, University of Michigan biologists have uncovered new clues about mysterious and contentious creatures called cancer stem cells.

10 Apr 2008

Potential drug target identified for diabetes by studying novel gut-brain-liver circuit

Scientists at the Toronto General Hospital Research Institute have discovered a novel signaling pathway between three organs - the gut, the brain, and the liver - which lowers blood sugar when activated.

10 Apr 2008

Too many gene copies stimulate tumor cell growth

New data, generated by Peter Lichter and colleagues, at the German Cancer Research Center, Heidelberg, have characterized a molecular pathway underlying low-grade forms of a type of brain tumor known as an astrocytoma.

9 Apr 2008

Negligent, attentive mouse mothers show biological differences

In mice, child neglect is a product of both nature and nurture, according to a new study.

9 Apr 2008

Potential new therapy for myeloproliferative disorders

A unique partnership between industry and academia has led to human clinical trials of a new drug for a rare class of blood diseases called myeloproliferative disorders (MPD), which are all driven by the same genetic mutation and can evolve into leukemia.

8 Apr 2008

New mathematical model provides new understanding of cell signaling

Looking for answers in the bright light of day, rather than the confined beam of a street light at night.

25 Mar 2008

Researchers reveal hidden properties of an on-off switch that governs cell growth

Investigators at the Duke Institute for Genome Sciences and Policy have revealed the hidden properties of an on-off switch that governs cell growth.

25 Mar 2008

Researchers discover signaling system that halts the growth of a childhood brain cancer

A discovery by St. Jude Children's Research Hospital scientists suggests a safer way to treat medulloblastoma, a rare but often fatal childhood brain tumor.

17 Mar 2008

Role for microRNAs in limb regeneration

In the March 15th issue of G&D, Dr. Kenneth Poss (Duke University Medical Center) and colleagues reveal that microRNA depletion is a necessary step in tissue regeneration - a discovery with interesting implications for their use in regenerative medicine.

17 Mar 2008

MicroRNAs help zebrafish regenerate fins

Biologists have discovered a molecular circuit breaker that controls a zebrafish's remarkable ability to regrow missing fins, according to a new study from Duke University Medical Center.

17 Mar 2008

Blood vessel protein reverses macular degeneration, diabetic retinopathy in mice

Two major eye diseases and leading causes of blindness—age-related macular degeneration and diabetic retinopathy can be reversed or even prevented by drugs that activate a protein found in blood vessel cells, researchers at the University of Utah School of Medicine and several other institutions have announced in a new study.

17 Mar 2008

Discovery could lead to much-needed kidney failure treatment

The unwanted activation of an important cell-signaling pathway may play a role in two kidney problems that are major causes of end-stage renal disease, scientists at the Albert Einstein College of Medicine of Yeshiva University have found.

13 Mar 2008

Study aims to improve treatment for children born with heart defects

Trying to understand and stop the collateral lung damage that can occur in babies with congenital heart disease is the focus of a new study.

11 Mar 2008

Genetic mutations involved in IGF-I signaling pathway influence life span

Mutations in genes governing an important cell-signaling pathway influence human longevity, scientists at the Albert Einstein College of Medicine of Yeshiva University have found.

6 Mar 2008

Adult stem cell changes underlie Hutchinson-Gilford Progeria syndrome associated with accelerated aging

Adult stem cells may provide an explanation for the cause of a Hutchinson-Gilford Progeria Syndrome (HGPS), a rare disease that causes premature aging in children, according to researchers at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH).

3 Mar 2008