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AlphaMissense revolutionizes genetic mutation analysis for disease prediction

AlphaMissense, an adaptation of AlphaFold, offers a highly accurate model for predicting the pathogenicity of human proteome-wide missense variants at the single amino acid level. The model outperforms existing methods, providing valuable insights for diagnosing rare diseases and developing targeted therapies.

20 Sep 2023

HNP-1 may be a promising therapeutic agent for hypertensive left ventricular hypertrophy

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Human neutrophil peptide-1 (HNP-1) is a commonly investigated therapeutic agent.

14 Sep 2023

Study sheds new light on the role of 'TonEBP' protein in lupus and lupus nephritis

A groundbreaking discovery has been made by Professor Hyug Moo Kwon and his research team in the Department of Biological Sciences at UNIST, in collaboration with Professor Jaeseok Yang from Yonsei University.

13 Sep 2023

A combination of inhibitors may suppress tumor growth and prevent cancer relapse

An international team of researchers has demonstrated that a combination of inhibitors may suppress tumor growth and prevent relapse in patients with certain cancers, including head and neck squamous cell carcinoma and lung adenocarcinoma.

12 Sep 2023

Arf1 inhibition induces tumor regression by promoting T cell infiltration

In recent years, cancer immunotherapies, represented by immune checkpoint blockade (ICB), have been highly successful and have become an important basis for the future treatment of cancers.

12 Sep 2023

Human post-implantation embryo models show promise in unraveling early development

Researchers evaluate post-implantation development in humans using embryo-like models based on genetically unmodified human naïve embryonic stem cells.

12 Sep 2023

Is DNA methylation the missing link in diagnosing and treating psoriasis and psoriatic arthritis?

Researchers across Europe have delved into the DNA methylation patterns in CD4+ T-cells of psoriasis and psoriatic arthritis (PsA) patients, unveiling potential new biomarkers for these conditions. Their study suggests that these unique profiles could serve as both diagnostic and prognostic tools, although further validation is needed for real-world clinical application.

10 Sep 2023

New way to administer CAR-T-cell therapy could lead to fewer side effects

When Richard O'Neil, Ph.D., joined MUSC Hollings Cancer Center two years ago, he knew that he wanted to continue finding ways to make CAR-T-cell therapy easier on patients.

8 Sep 2023

Eating your way out of pain: How your gut microbiota and diet can help manage chronic discomfort

A recent study in the Nutrients journal employs bibliometrics to explore how nutrition impacts the relationship between gut microbiota and chronic pain. The research highlights the potential of probiotics and prebiotics in managing pain conditions and underscores the need for further studies to understand the interplay between diet, gut health, and chronic pain.

28 Aug 2023

Ciliopathies: A new understanding of the role of the NSL complex

The non-specific lethal (NSL) complex is a chromatin-associated factor that has been shown to regulate the expression of thousands of genes in both fruit flies and mammals.

25 Aug 2023

UAB researchers show beneficial effect of verapamil for patients with Type 1 diabetes

In 2012, University of Alabama at Birmingham researcher Anath Shalev, M.D., reported that a decades-old blood pressure medication called verapamil completely reversed diabetes in animal models.

25 Aug 2023

Researchers discover new biological mechanism to regenerate and repair myelin

A study led by Dr. Hyun Kyoung Lee, associate professor at Baylor College of Medicine and investigator at the Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, has discovered a new biological mechanism to regenerate and repair myelin, a protective sheath that insulates neuronal fibers and plays a vital role in ensuring rapid and accurate neurotransmission.

24 Aug 2023

UC researchers study parasite that causes Chagas disease

Almost everything about insects called kissing bugs is revolting, from the insidious way they bite people's faces at night to drink their blood while they sleep to the way they spread disease through their poop.

23 Aug 2023

Genetic diversity important for plant survival in changing climate

In a recent study in PNAS, a team of researchers at the Max Planck Institute for Chemical Ecology in Jena, Germany, shows that a single mutation that has immediate effects on plant fitness is maintained over the long term in natural plant populations, despite theories predict the contrary.

21 Aug 2023

Study finds how low levels of the TET2 gene fuel rapid growth of acute myeloid leukemia

Scientists at City of Hope, one of the largest cancer research and treatment organizations in the United States, have identified how low levels of the TET2 gene fuel the rapid growth of acute myeloid leukemia in animal models.

17 Aug 2023

Study shows how brain rhythms can affect brain function by altering microglia and cytokines

Researchers used visual flickering sensory stimulation to reveal the underlying mechanisms governing microglial morphology and cytokine expression in mice.

16 Aug 2023

Glucokinase activators induce hepatic lipid accumulation in mice with high-fat diet

The researchers demonstrated that glucokinase activation was effective in lowering blood glucose in mice with high-fat diet-induced obesity, while it potentially raised the risk of increasing hepatic lipid accumulation that triggered the PERK-UPR pathway.

11 Aug 2023

Signaling Pathway News and Research

AlphaMissense revolutionizes genetic mutation analysis for disease prediction

HNP-1 may be a promising therapeutic agent for hypertensive left ventricular hypertrophy

Study sheds new light on the role of 'TonEBP' protein in lupus and lupus nephritis

A combination of inhibitors may suppress tumor growth and prevent cancer relapse

Arf1 inhibition induces tumor regression by promoting T cell infiltration

Human post-implantation embryo models show promise in unraveling early development

Is DNA methylation the missing link in diagnosing and treating psoriasis and psoriatic arthritis?

New way to administer CAR-T-cell therapy could lead to fewer side effects

Eating your way out of pain: How your gut microbiota and diet can help manage chronic discomfort

Ciliopathies: A new understanding of the role of the NSL complex

UAB researchers show beneficial effect of verapamil for patients with Type 1 diabetes

Researchers discover new biological mechanism to regenerate and repair myelin

UC researchers study parasite that causes Chagas disease

Genetic diversity important for plant survival in changing climate

Study finds how low levels of the TET2 gene fuel rapid growth of acute myeloid leukemia

Study shows how brain rhythms can affect brain function by altering microglia and cytokines

Glucokinase activators induce hepatic lipid accumulation in mice with high-fat diet

New mechanism discovered for brain repair after ischemic stroke

How conversion between different types of cell death contributes to disease

Mitochondrial protein structure activates cell's integrated stress response

Innovations in baculovirus–insect cell expression systems

Compound Management and its Crucial Role in Early Pharmaceutical Research

Natural products: the next frontier in drug discovery

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