Signaling Pathway News and Research

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Scientists solve mystery of why specific signaling pathway can be linked with alcohol dependence

Scientists at The Scripps Research Institute (TSRI) have solved the mystery of why a specific signaling pathway can be associated with alcohol dependence.

28 Aug 2014

Researchers show how interplay between nutrition, metabolism, immunity involved in ageing process

Researchers from UCL (University College London) have demonstrated how an interplay between nutrition, metabolism and immunity is involved in the process of ageing.

26 Aug 2014

Study shows new role for protein APC in suppressing colorectal cancer

A study recently published in the journal Carcinogenesis by researchers at the University of Kansas shows a new role for the protein adenomatous polyposis coli (APC) in suppressing colorectal cancer - the second-leading cause of cancer-related deaths in the U.S.

22 Aug 2014

Regulation of stem cells in zebrafish embryos results in surprising insights into Alzheimer's Disease

New fundamental knowledge about the regulation of stem cells in the nerve tissue of zebrafish embryos results in surprising insights into neurodegenerative disease processes in the human brain.

20 Aug 2014

Researchers find crucial signaling pathway that helps HSCs to generate

Hematopoietic stem cells (HSCs) give rise to all other blood cell types, but their development and how their fate is determined has long remained a mystery.

14 Aug 2014

Researchers gain rare insight into pregnancy-associated breast cancer

During pregnancy, certain hormones trigger specialized mammary stem cells to create milk-producing cells essential to lactation.

13 Aug 2014

Study identifies novel gene that controls nerve conduction velocity linked with MS

A new study published in The American Journal of Pathology identifies a novel gene that controls nerve conduction velocity.

13 Aug 2014

Notch signaling also plays important role in onset of obesity and Type 2 diabetes

A Purdue University study shows that Notch signaling, a key biological pathway tied to development and cell communication, also plays an important role in the onset of obesity and Type 2 diabetes, a discovery that offers new targets for treatment.

8 Aug 2014

Molecule Notch involved in fear memory formation

Nature is thrifty. The same signals that embryonic cells use to decide whether to become nerves, skin or bone come into play again when adult animals are learning whether to become afraid.

7 Aug 2014

Biologists identify signaling pathway that switches on calorie-burning process in brown fat cells

Biologists at The Scripps Research Institute (TSRI) have identified a signaling pathway that switches on a powerful calorie-burning process in brown fat cells.

1 Aug 2014

Signaling pathway key player in formation of front-most portion of developing vertebrate embryos

A signaling pathway once thought to have little if any role during embryogenesis is a key player in the formation of the front-most portion of developing vertebrate embryos.

18 Jul 2014

TAZ represents a novel therapeutic target in NSCLC

Patients with non-small-cell lung cancer who express high levels of transcriptional coactivator with PDZ-binding motif may be a clinically distinct subgroup with an unfavourable prognosis, researchers report.

16 Jul 2014

New role for cholesterol in activation of cellular signaling pathway that linked to cancer

Everyone knows that cholesterol, at least the bad kind, can cause heart disease and hardening of the arteries. Now, researchers at the University of Illinois at Chicago describe a new role for cholesterol in the activation of a cellular signaling pathway that has been linked to cancer.

15 Jul 2014

Scientists develop RNA that binds cGMP

The transmission of signals within cells is dependent on cyclic guanosine monophosphate (cGMP) as an important secondary messenger. German scientists have now developed an RNA that binds cGMP. As reported in the journal Angewandte Chemie, it is possible to suppress the cGMP signal cascade in genetically modified cells that produce this RNA.

10 Jul 2014

New knowledge may expand treatments for patients with lung cancer

Studying the most common type of lung cancer, researchers have uncovered mutations in a cell-signaling pathway that plays a role in forming tumors.

10 Jul 2014

TCGA finds novel mutations in key cancer-causing pathway in lung adenocarcinoma

Researchers from The Cancer Genome Atlas Research Network have identified novel mutations in a well-known cancer-causing pathway in lung adenocarcinoma, the most common subtype of lung cancer.

10 Jul 2014

Small antioxidant molecules suppress colon cancer associated with colitis

Researchers from Case Western Reserve and Dartmouth universities have shown that a class of small antioxidant molecules carries enormous promise for supressing colon cancer associated with colitis.

25 Jun 2014

Single dose restores normal cellular signaling in mouse model of autism

In a further test of a novel theory that suggests autism is the consequence of abnormal cell communication, researchers at the University of California, San Diego School of Medicine report that an almost century-old drug approved for treating sleeping sickness also restores normal cellular signaling in a mouse model of autism, reversing symptoms of the neurological disorder in animals that were the human biological age equivalent of 30 years old.

18 Jun 2014

Signaling pathway may help explain why body clocks of people with bipolar disease

Alterations in a cellular signaling pathway called cAMP-CREB may help explain why the body clocks of people with bipolar disease are out of sync, according to a new European Journal of Neuroscience study.

17 Jun 2014

Researchers uncover several gene networks with potentially important roles in autism

A large new analysis of DNA from thousands of patients has uncovered several underlying gene networks with potentially important roles in autism.

9 Jun 2014

Signaling Pathway News and Research

Scientists solve mystery of why specific signaling pathway can be linked with alcohol dependence

Researchers show how interplay between nutrition, metabolism, immunity involved in ageing process

Study shows new role for protein APC in suppressing colorectal cancer

Regulation of stem cells in zebrafish embryos results in surprising insights into Alzheimer's Disease

Researchers find crucial signaling pathway that helps HSCs to generate

Researchers gain rare insight into pregnancy-associated breast cancer

Study identifies novel gene that controls nerve conduction velocity linked with MS

Notch signaling also plays important role in onset of obesity and Type 2 diabetes

Molecule Notch involved in fear memory formation

Biologists identify signaling pathway that switches on calorie-burning process in brown fat cells

Signaling pathway key player in formation of front-most portion of developing vertebrate embryos

TAZ represents a novel therapeutic target in NSCLC

New role for cholesterol in activation of cellular signaling pathway that linked to cancer

Scientists develop RNA that binds cGMP

New knowledge may expand treatments for patients with lung cancer

TCGA finds novel mutations in key cancer-causing pathway in lung adenocarcinoma

Small antioxidant molecules suppress colon cancer associated with colitis

Single dose restores normal cellular signaling in mouse model of autism

Signaling pathway may help explain why body clocks of people with bipolar disease

Researchers uncover several gene networks with potentially important roles in autism

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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