Signaling Pathway News and Research

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Study suggests new strategy to ward off age-related weight gain

New research suggests a strategy to ward off age-related weight gain, which could prevent obesity and associated health disorders like Type 2 diabetes, heart disease and chronic inflammation.

7 Apr 2023

Researchers develop a biosensor for real time detection of the G-protein molecular switch

DGIST (President: Kook Yang) announced on March 16th that the research team led by Professor Byung-Chang Suh has investigated for the first time the real-time effect of the G-protein cycle, which acts as a switch in our body, on the structural changes in G protein-coupled receptors (GPCRs).

31 Mar 2023

Black sea urchin extract shows promise in combating atherosclerosis

A team of Italian scientists has identified potential anti-inflammatory and vasculoprotective effects of red cell extracts of the Black Sea urchin Arbacia lixula. The study has been published in the journal Nutrients.

30 Mar 2023

Experimental anti-obesity drug may control appetite without surgery or nausea

Imagine getting the benefits of gastric bypass surgery without going under the knife -; a new class of compounds could do just that. In lab animals, these potential treatments reduce weight dramatically and lower blood glucose.

29 Mar 2023

Drugs to activate STING could help prevent cancer metastasis

A team of scientists at the Sloan Kettering Institute have identified the STING cellular signaling pathway as a key player in keeping dormant cancer cells from progressing into aggressive tumors months, or even years, after they've escaped from a primary tumor.

29 Mar 2023

Targeting obesity: findings reveal a new molecular pathway involved in energy homeostasis regulation

Study outlines molecular mechanisms to aid the development of new therapies to manage obesity and associated health disorders.

29 Mar 2023

Newly found strategy used by metastasized tumors may explain why some promising immunotherapies fail

Cancer that has spread to areas like the lungs can apply the brakes to a natural pathway that should recruit killer T cells directly to where it has metastasized, scientists report.

28 Mar 2023

Targeting the STING pathway with a combination strategy promotes antitumor activity

Immunotherapies have greatly improved the outcomes of many patients with melanoma. But there is still a need for new approaches for the subset of patients who do not respond well to this type of therapy.

27 Mar 2023

How does diet affect inflammation?

In a recent study published in the journal Nutrients, researchers in Italy suggest there is evidence that dietary factors may directly affect the immune system and play a role in chronic systemic inflammation.

26 Mar 2023

Scientists uncover a link between cardiovascular disease and chronic kidney disease

Chronic kidney disease is linked to the formation of mineral deposits on blood vessel walls, known as "calcification", causing cardiovascular disease.

20 Mar 2023

Scientists develop genetically defined mouse models for multiple myeloma subtypes

A team of scientists led by Martin Janz and Klaus Rajewsky at the Max Delbrück Center has successfully generated genetically defined mouse models for two subtypes of multiple myeloma.

16 Mar 2023

Chemists reveal a whole new role for molecular mirroring

With the aid of some sea slugs, University of Nebraska–Lincoln chemists have discovered that one of the smallest conceivable tweaks to a biomolecule can elicit one of the grandest conceivable consequences: directing the activation of neurons.

15 Mar 2023

Hyperinflammation triggers long COVID headaches

Researchers characterize the immunological and metabolic alterations involved in chronic headache onset during post-acute sequelae of COVID-19.

13 Mar 2023

Newly identified bone matrix protein may help treat osteosarcoma

A study published in the Journal of Orthopaedic Research has identified a bone matrix protein called Secreted phosphoprotein 24 kD (Spp24) that may help to treat osteosarcoma, the most common type of bone cancer.

8 Mar 2023

New way to carry drugs across the blood-brain barrier using nanoparticles

Brain tumors are notoriously hard to treat. One reason is the challenge posed by the blood-brain barrier, a network of blood vessels and tissue with closely spaced cells.

3 Mar 2023

Role of phosphatidylinositol 3 kinase pathway in corneal damage due to blue light exposure

Researchers observe corneal damage by blue light exposure is due to PI3K/AKT pathway inhibition.

1 Mar 2023

Study reveals new mechanism in the arms race between bacteria and viruses

UT Southwestern biochemist Zhijian "James" Chen, Ph.D., famously identified the cGAS enzyme pathway that alerts the human immune system to disease-causing invaders like viruses.

28 Feb 2023

What is the effect of maternal circulating amino acids on offspring birthweight?

Researchers examined the effect of serum levels of 20 amino acids in a mother during pregnancy on offspring birthweight in a two-sample summary data Mendelian randomization framework.

27 Feb 2023

LMU physician uncovers mechanisms behind immune system immaturity in prematurely born infants

LMU physician Markus Sperandio has discovered why the immune system of prematurely born babies is not working properly after birth.

22 Feb 2023

Research identifies potential treatment target for infantile spasms syndrome

New research from Tufts University School of Medicine and the Graduate School of Biomedical Sciences suggests that the timing of the death of certain inhibitory neurons in the brain shortly after birth may be at least partly to blame for infantile spasms syndrome (ISS), a rare but devastating form of epilepsy that develops most frequently between four and eight months of age but can emerge within weeks of birth until ages 4 or 5.

21 Feb 2023

Signaling Pathway News and Research

Study suggests new strategy to ward off age-related weight gain

Researchers develop a biosensor for real time detection of the G-protein molecular switch

Black sea urchin extract shows promise in combating atherosclerosis

Experimental anti-obesity drug may control appetite without surgery or nausea

Drugs to activate STING could help prevent cancer metastasis

Targeting obesity: findings reveal a new molecular pathway involved in energy homeostasis regulation

Newly found strategy used by metastasized tumors may explain why some promising immunotherapies fail

Targeting the STING pathway with a combination strategy promotes antitumor activity

How does diet affect inflammation?

Scientists uncover a link between cardiovascular disease and chronic kidney disease

Scientists develop genetically defined mouse models for multiple myeloma subtypes

Chemists reveal a whole new role for molecular mirroring

Hyperinflammation triggers long COVID headaches

Newly identified bone matrix protein may help treat osteosarcoma

New way to carry drugs across the blood-brain barrier using nanoparticles

Role of phosphatidylinositol 3 kinase pathway in corneal damage due to blue light exposure

Study reveals new mechanism in the arms race between bacteria and viruses

What is the effect of maternal circulating amino acids on offspring birthweight?

LMU physician uncovers mechanisms behind immune system immaturity in prematurely born infants

Research identifies potential treatment target for infantile spasms syndrome

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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