Single Nucleotide Polymorphisms News and Research

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Harboring NRF2 gene may increase probability of being an endurance athlete

A few minor variations in one gene may make a difference in athletic endurance, according to a new study from Physiological Genomics.

19 Feb 2010

Study analyzes genome and exome sequence data from hunter-gatherer participants of South Africa

In a study published online today in Nature, a team of researchers from Penn State University and the University New South Wales present the complete genome sequences of an indigenous hunter-gatherer from the Kalahari Desert and a Bantu from southern Africa, along with three additional whole exome sequences of Kalahari hunter-gatherers.

19 Feb 2010

Study: Multiple genetic markers linked with CVD not associated with improvement in CVD risk prediction

Creation of a genetic risk score comprised of multiple genetic markers associated with cardiovascular disease (CVD) was not associated with significant improvement in CVD risk prediction in a study that included more than 19,000 women, according to a study in the February 17 issue of JAMA.

17 Feb 2010

Researchers find new risk factor for early-onset dementia

Examining brain tissue from over 500 individuals in 11 countries, researchers from the University of Pennsylvania School of Medicine and the Children's Hospital of Philadelphia, and colleagues found a new risk factor for the second-most-common cause of early-onset dementia after Alzheimer's disease.

16 Feb 2010

Genes of mother and fetus linked to risk of preterm labor and birth

New evidence that genetics play a significant role in some premature births may help explain why a woman can do everything right and still give birth too soon.

4 Feb 2010

Study finds link between genes that regulate maternal inflammatory response, bacterial vaginosis and preterm delivery

In a study to be presented today at the Society for Maternal-Fetal Medicine's (SMFM) annual meeting, The Pregnancy Meeting -, in Chicago, researchers will show the use of haplotype tagging (hap-tag) single-nucleotide polymorphisms (SNPs) to study the relationship between genetic predispositions, an environmental factor - bacterial vaginosis, and preterm birth.

4 Feb 2010

Genetic mutations may trigger suicidal behavior in depressed patients

Single mutations in genes involved with nerve cell formation and growth appear to be associated with the risk of attempting suicide among individuals with depression, according to a report posted online today that will appear in the April print issue of Archives of General Psychiatry, one of the JAMA/Archives journals.

2 Feb 2010

Targeted sequencing of exome can help identify potential disease-causing genes

Researchers from University of Miami Miller School of Medicine and Roche Applied Science have recently published a research study on human exome resequencing results from eight individuals that span across three generations of a family. The findings of this study showcased the value of targeted enrichment for family-based studies which allows researchers to quickly identify potential disease-causing genetic variants and will provide the data and information for further research to better understand disease and the impact across generations of a family.

29 Jan 2010

Researchers challenge prevailing assumptions in interpreting genome-wide studies

In the decade since the Human Genome Project produced the first map of DNA sequences in the human genome, scientists throughout the world have combed through genome data to identify genes and gene variants that cause human disease.

28 Jan 2010

Kalorama report predicts double-digit growth in SNP market

A setback in the scientific basis for SNP (single nucleotide polymorphisms) analysis may turn out to be a blessing in disguise for makers of genotyping equipment, reagents and software, according to Kalorama Information.

23 Jan 2010

Benefits of DNA testing

Does the term “genetic testing” conjure up thoughts of cloned, robot-like human beings and malevolent plots to rule the world? If so, you’ve been reading too much science fiction! The truth is, DNA testing has been put to very beneficial use for decades, primarily in the medical, law enforcement, and legal fields.

22 Jan 2010

Study shows an intriguing relationship between cancer-related genes and schizophrenia susceptibility

People who inherit a specific form of a gene that puts them on a road to schizophrenia may be protected against some forms of cancer, according to a new study by scientists at The Feinstein Institute for Medical Research.

20 Jan 2010

MAGIC investigators identify new genetic variants that influence insulin and glucose regulation

An international research consortium has found 13 new genetic variants that influence blood glucose regulation, insulin resistance, and the function of insulin-secreting beta cells in populations of European descent. Five of the newly discovered variants increase the risk of developing type 2 diabetes, the most common form of diabetes.

18 Jan 2010

Researchers identify new gene variants associated With glucose, insulin levels

A major international study with leadership from Massachusetts General Hospital (MGH) researchers has identified 10 new gene variants associated with blood sugar or insulin levels. Two of these novel variants and three that earlier studies associated with glucose levels were also found to increase the risk of type 2 diabetes. Along with a related study from members of the same research consortium, associating additional genetic variants with the metabolic response to a sugary meal, the report will appear in Nature Genetics and has been released online.

18 Jan 2010

Researchers uncover novel genetic markers for diabetes-related traits

In two major studies published in Nature Genetics today, researchers use biological understanding to dissect the genetics of diabetes. An international team comprising researchers from more than 100 institutions analysed vast suites of genetic data from more than 100,000 people of European descent to uncover the associations.

18 Jan 2010

Illumina launches HumanOmniExpress BeadChip for GWAS

Illumina, Inc. today announced the HumanOmniExpress BeadChip (OmniExpress), the newest addition to the Omni family of microarrays for genome-wide association studies (GWAS).

From Illumina, Inc. 11 Jan 2010

Variations in SNPs involved in modulating electrical impulse that govern working of heart discovered

Scientists at deCODE genetics today report the discovery of seven novel and common single-letter variations in the sequence of the human genome (SNPs) that are involved in modulating the electrical impulses that govern the working of the heart.

11 Jan 2010

Variants in CRP gene not associated with increased risk of cancer

Gene variants associated with increased circulating levels of C-reactive protein, a marker of inflammation, are not associated with an increased risk of cancer, according to a new brief communication published online January 7 in the Journal of the National Cancer Institute.

8 Jan 2010

Agilent Technologies, Covaris sign co-marketing agreement to streamline next-generation sequencing experiments

Agilent Technologies, Inc. (NYSE:A) and Covaris Inc. today announced a co-marketing agreement in which Covaris S2 DNA shearing technology will be marketed with the Agilent SureSelect Target Enrichment System to streamline next-generation sequencing experiments.

6 Jan 2010

Scientists develop straightforward technique to find ethnic origin of stem cells

An international team of scientists led by researchers at The Scripps Research Institute has developed a straightforward technique to determine the ethnic origin of stem cells.

30 Dec 2009

Single Nucleotide Polymorphisms News and Research

Harboring NRF2 gene may increase probability of being an endurance athlete

Study analyzes genome and exome sequence data from hunter-gatherer participants of South Africa

Study: Multiple genetic markers linked with CVD not associated with improvement in CVD risk prediction

Researchers find new risk factor for early-onset dementia

Genes of mother and fetus linked to risk of preterm labor and birth

Study finds link between genes that regulate maternal inflammatory response, bacterial vaginosis and preterm delivery

Genetic mutations may trigger suicidal behavior in depressed patients

Targeted sequencing of exome can help identify potential disease-causing genes

Researchers challenge prevailing assumptions in interpreting genome-wide studies

Kalorama report predicts double-digit growth in SNP market

Benefits of DNA testing

Study shows an intriguing relationship between cancer-related genes and schizophrenia susceptibility

MAGIC investigators identify new genetic variants that influence insulin and glucose regulation

Researchers identify new gene variants associated With glucose, insulin levels

Researchers uncover novel genetic markers for diabetes-related traits

Illumina launches HumanOmniExpress BeadChip for GWAS

Variations in SNPs involved in modulating electrical impulse that govern working of heart discovered

Variants in CRP gene not associated with increased risk of cancer

Agilent Technologies, Covaris sign co-marketing agreement to streamline next-generation sequencing experiments

Scientists develop straightforward technique to find ethnic origin of stem cells

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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