Small Molecules News and Research

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Tiny, touch-based sensor rapidly detects lithium levels from sweat on the surface of a fingertip

Lithium can alleviate the symptoms of bipolar disorder and depression -; if taken in just the right amount.

22 Aug 2022

Scientists begin phase 2 clinical trials of lupus pill

Lupus is an autoimmune disease that attacks organs and can be fatal. There's no cure, so current treatments aim to limit damage and ameliorate symptoms.

22 Aug 2022

New computation-guided approach to identify small molecule corrector drugs for p53 hotspot mutations

A new study, led by researchers from the University of California, Irvine and the University of California, San Diego, reveals a new computation-guided approach to identify small molecules that can restore aspects of wild-type p53 tumor suppression function to mutated p53, which play an important role in many human cancers.

11 Aug 2022

Researchers delve deeper into the structure of protein receptor crucial for cardiovascular health

5 Aug 2022

Combination of ultrasound and microbubbles helps medicines pass through the blood-brain barrier

Combining ultrasound and bubbles helps medicines pass through the protective blood-brain barrier and is giving hope for improved treatment of several diseases.

5 Aug 2022

Researchers discover two signaling pathways that are downregulated in human hearts after birth

Published today in Stem Cell Reports, researchers from the University of Minnesota Medical School discovered two signaling pathways that are downregulated in human hearts after birth.

4 Aug 2022

Turning to Organ-on-a-Chip Studies for the Future of Drug Discovery

In this interview, we speak to Tom Kostrzewski, VP of Science and Technology at CN Bio, about their organ-on-a-chip product and the future of drug discovery.

From CN-Bio 3 Aug 2022

Scientists identify papain-like protease inhibitor against COVID-19

In a new study, researchers identified a papain-like protease inhibitor for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.

25 Jul 2022

FDA clears IND application for MD Anderson-sponsored Phase I clinical study of OBX-115 therapy

The University of Texas MD Anderson Cancer Center and Obsidian Therapeutics, Inc. today announced Food and Drug Administration (FDA) clearance of an Investigational New Drug (IND) application for an MD Anderson-sponsored Phase I clinical study of OBX-115, Obsidian's lead engineered tumor infiltrating lymphocyte (TIL) therapy candidate.

21 Jul 2022

Cytokine-based cancer immunotherapy: current progress and future prospects

In this interview, News-Medical talks to Dr. Shuang Zhou about cytokine-base cancer immunotherapy, the current state of the field, and future prospects.

From Sino Biological Inc. 18 Jul 2022

New approach could pave the way for development of pan-coronavirus antivirals

To put the COVID-19 pandemic in the rearview mirror and prevent other coronaviruses from causing havoc, the world needs an arsenal of measures to prevent and treat these infections.

13 Jul 2022

Study assesses the potential of plant secondary metabolites as potential anti-COVID-19 agents

A new study has focused on identifying plant secondary metabolites (PSM) having a higher affinity for S-RBD of SARS-CoV-2.

11 Jul 2022

Scientists identify molecules promoting plant immunity

Two studies published by researchers at the Max Planck Institute for Plant Breeding Research in Cologne, Germany in collaboration with colleagues in China have discovered natural cellular molecules that drive critical plant immune responses.

7 Jul 2022

Chicoric acid a potential candidate for COVID-19 treatment

An article under review in the Scientific Reports journal and currently available on the Research Square* preprint server reports on chicoric acid (CA) as a potential inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

6 Jul 2022

Scientists explore mutations in the SARS-CoV-2 receptor-binding domain

Researchers assessed the different mutations of concern in the SARS-CoV-2 receptor-binding domain.

6 Jul 2022

Rapid test can identify which variant has infected a COVID-19 patient in just a few hours

In just a few hours, UT Southwestern scientists can tell which variant has infected a COVID-19 patient – a critical task that can potentially influence treatment decisions but takes days or weeks at most medical centers.

30 Jun 2022

MD Anderson announces collaborative alliance with Turning Point Therapeutics to advance new treatment options for cancer patients

The University of Texas MD Anderson Cancer Center and Turning Point Therapeutics, Inc., today announced a strategic research and development alliance to expand the evaluation of two of Turning Point's investigational small molecules focusing on precision medicine targets well known in oncology.

24 Jun 2022