Small Molecules News and Research

RSS

Engineered peptides show promise in cancer immunotherapy

In a new study published today in Nature Biomedical Engineering, researchers at The University of Texas MD Anderson Cancer Center have designed a new method for developing immunotherapy drugs using engineered peptides to elicit a natural immune response inside the body.

22 Apr 2024

AI techniques massively accelerate the search for Parkinson's disease treatments

Researchers have used artificial intelligence techniques to massively accelerate the search for Parkinson's disease treatments.

17 Apr 2024

Metrion Biosciences enhances High Throughput Screening services with access to Enamine compound libraries

...

From Metrion Biosciences Limited 11 Apr 2024

How gut microbiome influences obesity onset differently in men and women

New research being presented at this year's European Congress on Obesity (ECO) in Venice, Italy (12-15 May) identifies changes in the composition of gut bacteria that may play a key role in the onset and development of obesity, with differences in men and women, which might affect the metabolism of different nutrients and therefore the presence of bioactive molecules in the gut that influence the development of metabolic disease.

2 Apr 2024

Focusing on oncogenic driver mutations and resistance mechanisms in the treatment of NSCLC

Lung cancer is the leading cause of cancer-related death worldwide. Improved understanding of driver mutations of non-small cell lung cancer (NSCLC) has led to more biomarker-directed treatment for patients with advanced stages.

26 Mar 2024

New drug candidates show promise to reverse HIV immune evasion

University of Pittsburgh School of Medicine scientists have identified drug candidates that show promise to reverse the ability of HIV to escape detection by the immune system.

19 Mar 2024

Unlocking weight loss through exercise mimicry with metformin

An "anti-hunger" molecule produced after vigorous exercise is responsible for the moderate weight loss caused by the diabetes medication metformin, according to a new study in mice and humans.

18 Mar 2024

Synthetic mucins shed light on cancer biology and tumor formation

During cold and flu season, excess mucus is a common, unpleasant symptom of illness, but the slippery substance is essential to human health.

18 Mar 2024

Gut bacteria and tryptophan diet can play a protective role against pathogenic E. coli

Gut bacteria and a diet rich in the amino acid tryptophan can play a protective role against pathogenic E. coli, which can cause severe stomach upset, cramps, fever, intestinal bleeding and renal failure, according to a study published March 13 in Nature.

14 Mar 2024

Researchers shed light on cancer cell survival in early hypoxia

Researchers at the Francis Crick Institute have shed light on how cancer cells survive in the first few hours after being cut off from a supply of oxygen.

14 Mar 2024

Researchers forge new path to combat viruses and cancers with helicase inhibitors

Helicases are enzymes that unwind DNA and RNA. They're central to cellular life, implicated in a number of cancers and infections-;and, alas, extraordinarily difficult to target with drugs.

9 Mar 2024

Molecular glue could pave the way for new generation of drugs

A breakthrough class of molecular glue identified at the University of Dundee could pave the way for a new generation of drugs to target cancers and neurodegenerative diseases.

21 Feb 2024

Study suggests high levels of vitamin B3 breakdown products are linked to higher risk of mortality, heart attacks, and stroke

Researchers utilized an untargeted metabolomics technique to look for new compounds and pathways that may contribute to residual cardiovascular disease risk.

19 Feb 2024

Phosphoproteomic profiling reveals the complex interplay of immune cells in tumors

Researchers from the Icahn School of Medicine at Mount Sinai, in collaboration with the Clinical Proteomic Tumor Analysis Consortium of the National Institutes of Health, The University of Texas MD Anderson Cancer Center, Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, and others, have unveiled a detailed understanding of immune responses in cancer, marking a significant development in the field.

14 Feb 2024

New method traces primed resistance in cancer via sister cells

In many cancers, such as ovarian cancer, each round of chemotherapy kills the majority of cancer cells, while a small population of them survives through treatment.

12 Feb 2024

New research shows promise for urine-based test to detect ovarian cancer

New research by Joseph Reiner and colleagues at Virginia Commonwealth University shows promise for a urine-based test for ovarian cancer. Reiner will present their research at the 68th Biophysical Society Annual Meeting, to be held February 10 - 14, 2024 in Philadelphia, Pennsylvania.

12 Feb 2024

New study identifies key role of microRNA-29 in scar-free wound healing

New findings in The American Journal of Pathology, published by Elsevier, report that a class of small RNAs (microRNAs), microRNA-29, can restore normal skin structure rather than producing a wound closure by a connective tissue (scar).

2 Feb 2024

New insights on how diet regulates allergic responses

The intricate relationship that exists between humans and the gut microbiome has become a hot research topic, and scientists are constantly uncovering new reasons why a healthy diet can lead to a healthier life.

1 Feb 2024

Study sheds light on 7-DHC's potential to induce cell death-resistant state in tumors

Cell death is fundamental to life and, thus, healthy aging. In the realm of cellular biology, ferroptosis (a form of programmed cell death) has emerged not only as a focal point of research for its potential in eliminating cancer cells, but also its role in a plethora of other diseases, including neurodegenerative diseases such as Alzheimer's disease, eye diseases such as Retinitis pigmentosa and age-related macular degeneration, as well as ischemia, cardiovascular disease, liver disease, acute kidney injury and inflammation.