Small Molecules News and Research

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Chemicals accumulated in the vagina may contribute to spontaneous preterm birth

Chemicals that accumulate in the vagina, potentially originating from personal care products, may contribute to spontaneous preterm birth, according to a new study by researchers at Columbia University Vagelos College of Physicians and Surgeons.

13 Jan 2023

Pheno Therapeutics announces worldwide license from UCB to a novel program for neurodegenerative disease

Pheno Therapeutics Limited., a biotechnology company focused on the discovery and development of small molecule therapeutics that promote remyelination for the treatment of neurological diseases such as multiple sclerosis, announced today it has entered into an exclusive worldwide license agreement with UCB.

12 Jan 2023

Using lipid nanoparticles and messenger RNA to treat blindness associated with rare genetic condition

Oregon State University College of Pharmacy scientists have demonstrated in animal models the possibility of using lipid nanoparticles and messenger RNA, the technology underpinning COVID-19 vaccines, to treat blindness associated with a rare genetic condition.

11 Jan 2023

Can diets reverse or delay aging?

A new study published in the journal Science aimed to summarize the commonly studied anti-aging dietary interventions and their impact on human health and longevity.

10 Jan 2023

CU researchers discover a new mechanism for slowing cardiac fibrosis

Researchers at the University of Colorado School of Medicine have discovered a new mechanism for slowing scarring of heart tissue -; a process known as cardiac fibrosis.

6 Jan 2023

Latest discovery provides new understanding of the fundamental mechanics of the human brain

From the complexity of neural networks to basic biological functions and structures, the human brain only reluctantly reveals its secrets.

5 Jan 2023

Researchers develop new tool to isolate and analyze rare astrocyte regulators

Rare cell types can have an undue influence on human health. Previous research has suggested that a subset of astrocytes-;star-shaped cells in the brain and spinal cord-;may be responsible for multiple sclerosis (MS), a disease in which the immune system attacks the covering that protects nerves.

4 Jan 2023

Gut-dwelling bacteria can promote the desire to exercise, study shows

Some species of gut-dwelling bacteria activate nerves in the gut to promote the desire to exercise, according to a study in mice that was led by researchers at the Perelman School of Medicine at the University of Pennsylvania.

15 Dec 2022

Research reveals the assembly dynamics of nucleocapsid protein condensates can be regulated by small molecules with therapeutic potential

Researchers developed a screening platform and identified molecules with anti-CoV activity.

12 Dec 2022

Discovery of cellular uptake pathway for larger molecules can be harnessed to create new drugs

A fundamental challenge in drug development is the balance between optimizing a drug's lock-and-key fit with its target and the drug's ability to make its way across the cellular membrane and access that target.

8 Dec 2022

Integrated approach addresses some of the biggest challenges in natural products drug discovery

Many successful drugs have their origins in natural sources such as plants, fungi, and bacteria, but screening natural products to identify potential drugs remains a difficult undertaking.

1 Dec 2022

Fingerprint-embedding framework can help find novel drug candidates

Researchers have developed a new computer framework that holds promise in the work to discover new drugs. Their framework uses an artificial intelligence method called convolutional neural network to provide global information about potential novel drug candidates.

30 Nov 2022

New guidelines for designing synthetic molecules that block interaction between two proteins

Inside cells, proteins constantly interact with each other to carry out different functions. For some diseases in which these functions are altered, blocking the binding between two or more proteins emerges as a possible therapeutic approach.

30 Nov 2022

Researchers discover a new function of CRISPR/Cas9 gene scissors

For several years now, the CRISPR/Cas9 gene scissors have been causing a sensation in science and medicine.

25 Nov 2022

Research reveals existence of a hidden ''pocket’ on the surface of key SARS-CoV-2 protein

With the continuous emergence of new variants and the risk of new strains of the virus, the development of innovative therapies against SARS-CoV-2 remains a major public health challenge.

23 Nov 2022

Molecular motion of many 'undruggable' proteins reveals previously unseen binding sites

Studying the molecular motion of proteins reveals previously unseen binding sites that could be targeted by new drug candidate molecules.

21 Nov 2022

Research reveals new treatment avenue for pediatric high grade gliomas harboring a genetic mutation

Researchers at the University of Michigan Rogel Cancer Center have identified a novel treatment approach to an aggressive type of pediatric brain cancer, using therapies already approved to treat cancer.

16 Nov 2022

Small molecules found in breast milk may reduce the likelihood of infants developing allergies

Breastfed babies are believed to suffer fewer allergic conditions, like eczema and food allergies, than formula-fed babies; yet the reason has not been well understood.

15 Nov 2022

UCR scientists pave the way for diabetes and cancer patients to forget injections

Researchers at UC Riverside are paving the way for diabetes and cancer patients to forget needles and injections, and instead take pills to manage their conditions.

10 Nov 2022

Study illuminates how a typical gut bacterium spreads through the body

A typical gut bacterium that can spread through the body and cause a serious infection resists natural immune defenses and antibiotics by enhancing its protective outer layer, known as the cell envelope, according to a new study by Weill Cornell Medicine investigators.