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Why different tissues in the human body vary in their susceptibility to "amyloid" diseases

Researchers at The Scripps Research Institute are reporting the results of a recent study that addresses why different tissues in the human body vary in their susceptibility to "amyloid" diseases, which include Alzheimer's disease and a cluster of ailments called the familial amyloidoses.

7 Apr 2005

New chemicals to inhibit HIV infection

In corporation with peers from the Mount Sinai School of Medicine, New York University, researchers from the University of Science and Technology of China (USTC), a CAS affiliate, have come up with new chemical inhibitors against HIV reproduction, marking a significant progress in the development of anti-AIDS drugs based on natural host resistance.

4 Apr 2005

Young blood revives aging muscles

Any older person can attest that aging muscles don't heal like young ones. But it turns out that's not the muscle's fault. A study in the Feb. 17 issue of Nature shows that it's old blood that keeps the muscles down.

16 Feb 2005

New way of transporting medicines into the brain

Dutch researcher Corine Visser investigated a new way of transporting medicines into the brain. Her approach made use of an iron transport system located on the blood-brain barrier. The smaller the medicine, the more easily it penetrates the brain.

13 Feb 2005

Available lines of human embryonic stem cells have been contaminated

Currently available lines of human embryonic stem cells have been contaminated with a non-human molecule that compromises their potential therapeutic use in human subjects, according to research by investigators at the University of California, San Diego (UCSD) School of Medicine and the Salk Institute in La Jolla, California.

24 Jan 2005

Next-generation therapeutics with the potential to successfully treat Lou Gehrig's disease

The hopes of many that ALS (commonly referred to as Lou Gehrig's disease) will one day be a disease of the past, studied in medical textbooks, conquered by the dedication of those who have worked tirelessly to eradicate it might be realized in our lifetime.

6 Dec 2004

Cellular enzyme represents a potential new target for developing improved HIV drugs

Scientists have discovered that a cellular enzyme helps ferry HIV genetic instructions out of the cell nucleus where they can then be translated into proteins to begin their most destructive work.

1 Nov 2004

Trojan horse technique offers potential new therapeutic approach to Alzheimer's disease

A potential new therapeutic approach to Alzheimer's disease protects brain cells in culture by drastically reducing the neurotoxic amyloid protein aggregates that are critical to the development of the disease.

29 Oct 2004

Patent pending discovery could help type 2 diabetics

Scientists from MitoChroma Research have recently announced a patent-pending discovery that could complement current medical management modalities for Type 2 Diabetes, insulin resistance and the set of related conditions called "Metabolic Syndrome."

4 Oct 2004

Researchers have successfully targeted an HIV protein that has eluded existing therapies

Researchers targeted Nef, a protein responsible for accelerating the development of acquired immunodeficiency syndrome, or AIDS. Nef was targeted with small molecules synthesized by the researchers – molecules that disrupted Nef’s interaction with other proteins.

26 Sep 2004

Drug combo may have a greater impact on cancer development

Cancer researchers have long suggested that new targeted drugs may work best when paired with other therapies. In a new study published today in Cancer Research, scientists have taken some of the first steps to demonstrate this synergy in mouse and cell line models.

16 Sep 2004

Liver cancer genes cluster into two subsets that correlate to survival

An analysis of the gene expression patterns of 91 unrelated liver tumors revealed two distinctive subclasses highly associated with patient survival, according to a new study published in the September 2004 issue of Hepatology.

14 Sep 2004

Scientists have uncovered a key driver behind the progression of prostate cancer

Scientists at Fred Hutchinson Cancer Research Center have uncovered a key driver behind the progression of prostate cancer, a discovery that the researchers believe could spawn new treatments to prevent the cancer's spread and extend survival.

23 Aug 2004

Small molecules as artificial gene regulators

Scientists have been trying for some time to develop molecules that mimic natural regulators of gene expression.

22 Aug 2004

Existing hepatitis drug could lead to the development of new drugs for the treatment of anthrax

Thanks to new screening tools, and some luck, researchers at the University of Chicago have discovered three unrelated compounds that inhibit the two toxins – edema factor and lethal factor -- that have made anthrax one of the most feared of potential bioterror agents.

21 Aug 2004