Smallpox News and Research

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Smallpox is a highly contagious disease caused by the variola virus, a member of the Orthopox virus family. It is one of the most devastating diseases known to humanity, with a mortality rate as high as 30%. In 1967, the World Health Organization embarked upon an intensified vaccination campaign to eliminate smallpox, which culminated in the successful eradication of the disease globally by 1980.

By the mid-1980s, there were only two known repositories of variola virus: the Institute of Virus Preparations in Russia, and the US CDC. The events in the US in September and October 2001 highlighted the risk that the variola virus might be used as an agent of bioterrorism. Governments around the world are taking precautionary measures to be ready to deal with a potential smallpox outbreak.

War wounded at risk for superbugs

Soldiers who survive severe injuries on battlefields such as those in Iraq and Afghanistan can be at risk from developing infections of their wounds with multidrug resistant bacteria.

30 Mar 2009

Tissue-cultured smallpox vaccine shows promise

Administration of a tissue-cultured smallpox vaccine showed signs of an effective vaccine response with no serious adverse events, according to a study in the March 11 issue of JAMA, the Journal of the American Medical Association.

11 Mar 2009

A vaccine for multiple sclerosis

Apitope Technology Ltd is a biopharmaceutical company that specialises in developing treatments for allergy and autoimmune diseases.

11 Mar 2009

Virus reveals secret to cancer spread

Cancer Research UK scientists studying a virus have unveiled an important clue to understanding how cancer spreads. Their research is published in Nature.

4 Mar 2009

Poxvirus breakthrough

Smallpox has a nasty history throughout the world.

19 Jan 2009

Bavarian Nordic's patent infringement suit against Oxford BioMedica

Bavarian Nordic owns several United States patents relating to an attenuated strain of the company's core technology, MVA-BN(R), which is the basis for its smallpox vaccine, IMVAMUNE(R).

12 Jan 2009

Chimerix completes phase I study and starts phase II multi-dose trial for CMX001

Chimerix, Inc., a biotechnology company developing orally available antiviral therapeutics, has announced that the Company has completed a single and multi-dose Phase I study of CMX001 in healthy volunteers.

6 Jan 2009

Mathematical models of adaptive immunity

More than five million people die every year from infectious diseases, despite the availability of numerous antibiotics and vaccines. The discovery of penicillin to treat bacterial infections, along with the development of vaccines for previously incurable virus diseases such as polio and smallpox, achieved great reductions in mortality during the mid-20th century.

11 Dec 2008

New study indicates smallpox vaccination effective for decades

Although naturally occurring smallpox was eradicated in 1977, there is concern that bioterrorists might obtain smallpox from a laboratory and release it into the population.

30 Nov 2008

Peregrine Pharmaceuticals awarded U.S. patent for anti-viral applications of phospholipid-targeting antibodies

Peregrine Pharmaceuticals, Inc. has announced that the U.S. Patent and Trademark Office has issued U.S. Patent Number No. 7,455,833, which includes broad claims covering anti-viral applications of antibodies that directly bind to aminophospholipids.

25 Nov 2008

Live oral Shigella vaccine licensed to PATH

The University of Maryland, Baltimore (UMB) has licensed a pediatric vaccine against Shigella bacteria to PATH, an international nonprofit group, to support clinical trials, with the goal of developing a vaccine suitable for children in resource-poor countries.

24 Nov 2008

Universal flu vaccine the 'Holy Grail' of flu shots

Scientists say a universal flu vaccine still in the pipeline could see an end to the annual flu shot.

8 Sep 2008

NanoBio vaccine for hepatitis B shows promise

Chronic hepatitis B infects 400 million people worldwide, many of them children. Even with three effective vaccines available, hepatitis B remains a stubborn, unrelenting health problem, especially in Africa and other developing areas. The disease and its complications cause an estimated 1 million deaths globally each year.

13 Aug 2008

Bavarian Nordic files patent infringement suit against Oxford BioMedica

Bavarian Nordic has filed a patent infringement suit against Oxford BioMedica plc, Biomedica, Inc., and Oxford BioMedica Ltd., in the United States District Court of the Southern District of California.

30 Jun 2008

BN ImmunoTherapeutics starts clinical trials with prostate cancer vaccine

BN ImmunoTherapeutics, Inc. has initiated Phase I/II clinical studies with its therapeutic vaccine candidate against prostate cancer.

4 Jun 2008

Investigational smallpox drug may treat adenovirus infections in humans

Scientists at Saint Louis University have made two key discoveries that could lead to the first-ever human testing of a drug to target the adenovirus, which causes a number of severe upper-respiratory infections and is one of many viruses that causes the common cold.

19 May 2008

Drug candidate to treat smallpox scaled up by new partnership

Two American companies are teaming up for second-round test-phase production of a FDA-designated "fast track" drug candidate to treat smallpox, a deadly virus that is feared to be able to reach people through acts of bio-warfare or bio-terrorism.

5 May 2008

Red colobus monkeys in Uganda found to harbor antibodies to an unknown orthopoxvirus

Researchers report this month that red colobus monkeys in a park in western Uganda have been exposed to an unknown orthopoxvirus, a pathogen related to the viruses that cause smallpox, monkeypox and cowpox. Most of the monkeys screened harbor antibodies to a virus that is similar - but not identical - to known orthopoxviruses.

22 Apr 2008

Human vaccine for Ebola in the pipeline

The deadly Ebola virus is in the news again but this time there is the promise of a vaccine for the deadly disease.

1 Apr 2008

Most people believe smallpox not an extinct disease

The vast majority of Scottish people interviewed in the streets of Edinburgh are unaware of one of the greatest achievements of medical science - the eradication of smallpox from the world over 40 years ago.

31 Mar 2008