Smallpox News and Research

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Smallpox is a highly contagious disease caused by the variola virus, a member of the Orthopox virus family. It is one of the most devastating diseases known to humanity, with a mortality rate as high as 30%. In 1967, the World Health Organization embarked upon an intensified vaccination campaign to eliminate smallpox, which culminated in the successful eradication of the disease globally by 1980.

By the mid-1980s, there were only two known repositories of variola virus: the Institute of Virus Preparations in Russia, and the US CDC. The events in the US in September and October 2001 highlighted the risk that the variola virus might be used as an agent of bioterrorism. Governments around the world are taking precautionary measures to be ready to deal with a potential smallpox outbreak.
State-of-the-art Biocontainment Unit opened at MedStar Washington Hospital Center

State-of-the-art Biocontainment Unit opened at MedStar Washington Hospital Center

Researchers analyze the ancestry components in modern and historic VARV genomes

Researchers analyze the ancestry components in modern and historic VARV genomes

Discovery of a potential new target for new MPOX or broad pox vaccines

Discovery of a potential new target for new MPOX or broad pox vaccines

Genomic analysis of mpox virus genomes reveal multiple lineages with human-to-human transmissibility

Genomic analysis of mpox virus genomes reveal multiple lineages with human-to-human transmissibility

Study suggests a single dose of JYNNEOS vaccine may lessen the severity of mpox illness

Study suggests a single dose of JYNNEOS vaccine may lessen the severity of mpox illness

Novel mRNA-lipid nanoparticle vaccine encoding four mpox virus surface proteins generates robust immune responses against orthopoxviruses

Novel mRNA-lipid nanoparticle vaccine encoding four mpox virus surface proteins generates robust immune responses against orthopoxviruses

Characterization of anti-orthopoxvirus antibody response in general population and gay men

Characterization of anti-orthopoxvirus antibody response in general population and gay men

Single-dose smallpox vaccine could be effective against mpox

Single-dose smallpox vaccine could be effective against mpox

Study examines Mpox prevention with modified vaccinia Ankara (MVA)

Study examines Mpox prevention with modified vaccinia Ankara (MVA)

Knowledge and attitudes to mpox among GBMSM in Australia

Knowledge and attitudes to mpox among GBMSM in Australia

Enveloped viruses show greater cross-species transmission, according to new research

Enveloped viruses show greater cross-species transmission, according to new research

Exploring immunogenicity, boosting efficacy and safety of modified vaccinia Ankara-Bavarian Nordic vaccine

Exploring immunogenicity, boosting efficacy and safety of modified vaccinia Ankara-Bavarian Nordic vaccine

Vaccine MVA-BN shows consistent, robust immunogenicity and safety results

Vaccine MVA-BN shows consistent, robust immunogenicity and safety results

Mpox virus from Clade 2b is the least virulent strain according to new study

Mpox virus from Clade 2b is the least virulent strain according to new study

New evidence of mpox virus transmission before onset of symptoms

New evidence of mpox virus transmission before onset of symptoms

Monkeypox renamed "mpox" in an effort to combat stigma

Monkeypox renamed "mpox" in an effort to combat stigma

Small UK study investigates the effectiveness of a single MVA-BN dose against mpox disease

Small UK study investigates the effectiveness of a single MVA-BN dose against mpox disease

Modeling study offers a road map for public health to maximize the impact of monkeypox vaccines

Modeling study offers a road map for public health to maximize the impact of monkeypox vaccines

Novel mRNA vaccines encoding Monkeypox virus proteins show promise in preclinical studies

Novel mRNA vaccines encoding Monkeypox virus proteins show promise in preclinical studies