Smallpox News and Research

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Smallpox is a highly contagious disease caused by the variola virus, a member of the Orthopox virus family. It is one of the most devastating diseases known to humanity, with a mortality rate as high as 30%. In 1967, the World Health Organization embarked upon an intensified vaccination campaign to eliminate smallpox, which culminated in the successful eradication of the disease globally by 1980.

By the mid-1980s, there were only two known repositories of variola virus: the Institute of Virus Preparations in Russia, and the US CDC. The events in the US in September and October 2001 highlighted the risk that the variola virus might be used as an agent of bioterrorism. Governments around the world are taking precautionary measures to be ready to deal with a potential smallpox outbreak.

Polio eradicated in Somalia

Somalia is again polio-free, the Global Polio Eradication Initiative (GPEI) announced today, calling it a 'historic achievement' in public health.

26 Mar 2008

MIT cell-based sensor technology quickly detects airborne pathogens

Researchers at MIT Lincoln Laboratory have developed a powerful sensor that can detect airborne pathogens such as anthrax and smallpox in less than three minutes.

6 Mar 2008

Nasal vaccine for smallpox protects animals against 77 times the potentially lethal dose of smallpox

Scientists at NanoBio Corporation and the University of Michigan have demonstrated their nasally delivered vaccinia vaccine can protect animals against 77 times the potentially lethal dose of smallpox, and without the safety risks of current vaccines for smallpox.

27 Feb 2008

Nanoemulsion vaccines show increasing promise

A novel technique for vaccinating against a variety of infectious diseases - using an oil-based emulsion placed in the nose, rather than needles - has proved able to produce a strong immune response against smallpox and HIV in two new studies.

27 Feb 2008

New discovery, immune cells confront viruses just inside of the lymph node

Vaccines have led to many of the world's greatest public health triumphs, but many deadly viruses, such as HIV, still elude the best efforts of scientists to develop effective vaccines against them. An improved understanding of how the immune system operates during a viral infection is critical to designing successful anti-virus vaccines.

4 Feb 2008

Cell death suppression increases efficacy of M2 vaccines

Significant public attention has recently been focused on the development of new anti-influenza (flu) vaccines that provide protection against a broad spectrum of viral strains.

17 Jan 2008

Potential alternative to the existing smallpox vaccine

University of California, Irvine infectious disease researchers have shown the effectiveness of a potential alternative to the existing smallpox vaccine that can replace the current biodefense stockpile for this lethal virus.

8 Jan 2008

New international health regulations now in force

New International Health Regulations (IHR)-designed to halt the international spread of dangerous diseases and other threats-are now in force, with the chief aim of reducing the time it takes to identify an illness or other public health threat-including chemical and radiological hazards-that could have an international impact, in order to mobilize a more timely and effective response.

7 Jan 2008

Human evolution in genetic fast lane

Countering a common theory that human evolution has slowed to a crawl or even stopped in modern humans, a new study examining data from an international genomics project describes the past 40,000 years as a time of supercharged evolutionary change, driven by exponential population growth and cultural shifts.

10 Dec 2007

Poxvirus' ability to hide from the immune system may aid vaccine design

The cowpox virus, a much milder cousin of the deadly smallpox virus, can keep infected host cells from warning the immune system that they have been compromised, researchers at Washington University School of Medicine in St. Louis have found.

16 Nov 2007

number of cases of most vaccine-preventable diseases is at an all-time low

A comparison of illness and death rates for 13 vaccine-preventable diseases in the U.S., before and after use of the vaccine, indicates there have been significant decreases in the number of cases, hospitalizations and deaths for each of the diseases examined, according to a study in the November 14 issue of JAMA: The Journal of the American Medical Association.

14 Nov 2007

Bavarian Nordic updates on vaccine project pipeline

In a business update, Danish-based biopharmaceutical company Bavarian Nordic, reported a number of developments in its vaccine project pipeline.

6 Nov 2007

Smallpox evolved earlier than believed

Smallpox is older than thought, according to results of a new technique reported in the Sept. 24 issue of the Proceedings of the National Academy of Sciences by researchers from Lawrence Livermore National Laboratory and the Centers for Disease Control (CDC).

27 Sep 2007