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Comprehensive atlas of protein kinases could help scientists decipher many cellular signaling pathways

One of the most important classes of human enzymes are protein kinases -; signaling molecules that regulate nearly all cellular activities, including growth, cell division, and metabolism.

12 Jan 2023

Unique mass spectrometry-based approach to study specific changes in DNA after replication

A new method to study specific changes in DNA after replication has been published as a technical report in Nature Cell Biology.

12 Jan 2023

Spike protein mutations in Omicron subvariants increase their susceptibility to reductive cleavage of disulfide bonds

Researchers discovered that the spike protein of SARS-CoV-2 is susceptible to cleavage at the disulfide bonds, and the vulnerability to reductive cleavage varies across variants, with the Omicron variant family being highly susceptible to reduction.

10 Jan 2023

Researchers demonstrate the role of Klotho protein in the formation of osteoarthritis

Researchers in the United States and Japan have discovered a new mechanism that links age-related cartilage tissue stiffening with the repression of a key protein associated with longevity.

10 Jan 2023

Evosep receives strategic investment from Novo Holding A/S to accelerate its effort on clinical proteomics

Evosep today announced that Novo Holdings A/S has become a minority shareholder in Evosep Aps with a US$ 40m investment to further Evosep’s technology and application portfolio for clinical proteomics.

From Evosep 10 Jan 2023

New Bruker-Biognosys collaboration aims to deliver advanced proteomics CRO services

Bruker Corporation and Switzerland-based Biognosys AG today announced a strategic partnership, in which Bruker has made a majority-ownership investment in Biognosys. Financial details were not disclosed. J.P.Morgan acted as exclusive financial advisor to Biognosys.

From Bruker BioSpin - NMR, EPR and Imaging 10 Jan 2023

Circulating microparticle proteins predict placenta accreta spectrum before delivery

A recent study published in the journal Scientific Reports reported that circulating microparticle (CMP) proteins predict pregnancies complicated by placenta accreta spectrum (PAS).

9 Jan 2023

Cells live longer when they exchange metabolic products with each other

When cells exchange metabolic products with other cells, they live longer. This new finding comes from a research team at Charité – Universitätsmedizin Berlin, which made the discovery in a study using yeast cells.

6 Jan 2023

New insights into the bioavailability and hepatoxicity risk of neonicotinoids

Researchers quantified the residues of eight neonicotinoids in human bile samples to understand the association between internal neonicotinoid exposure and hepatotoxic outcomes.

4 Jan 2023

Technical advances expand the application of mass spectrometry imaging in pharmaceutical research

Announcing a new publication for Acta Materia Medica journal. Mass spectrometry imaging (MSI) has been shown to be a valuable tool through nearly every stage of the preclinical drug research and development (R&D) pipeline, and even to the early phase of clinical pharmaceutical evaluation.

3 Jan 2023

Insulin-like peptide 3 may be a predictor of hypogonadism and age-associated morbidity in older males

Researchers evaluated whether insulin-like peptide 3 (INSL3) could predict hypogonadism and age-associated morbidity in older males.

3 Jan 2023

Horizontal gene transfer from mother to infant influences gut microbiome assembly, neurodevelopment, and immune maturation in infants

Researchers used a multi-omics approach to profile the gut microbiomes and metabolomes of mothers and infants to determine the vertical and horizontal transmission of bacterial species and strains as well as individual genes and understand the dynamics of the gut microbiome assembly that shape the development of the infant before and after birth.

29 Dec 2022

Scientists explore synthesis of griffithsin in cell-free systems

A new study described the cell-free manufacturing of griffithsin (GRFT), a broad-spectrum antiviral protein.

28 Dec 2022

DISCO-MS technology enables the study of diseases at their earliest stages

How can you trace a single diseased cell in an intact brain or a human heart? The search resembles looking for a needle in a haystack.

22 Dec 2022

Study identifies four new monoclonal antibodies with broad neutralizing potencies that target conserved SARS-CoV-2 epitopes

Researchers described four novel monoclonal antibodies with potent and broad neutralization activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, including the current globally dominant Omicron BA.4/BA.5.

20 Dec 2022

Spectrometry News and Research

Comprehensive atlas of protein kinases could help scientists decipher many cellular signaling pathways

Unique mass spectrometry-based approach to study specific changes in DNA after replication

Spike protein mutations in Omicron subvariants increase their susceptibility to reductive cleavage of disulfide bonds

Researchers demonstrate the role of Klotho protein in the formation of osteoarthritis

Evosep receives strategic investment from Novo Holding A/S to accelerate its effort on clinical proteomics

New Bruker-Biognosys collaboration aims to deliver advanced proteomics CRO services

Circulating microparticle proteins predict placenta accreta spectrum before delivery

Cells live longer when they exchange metabolic products with each other

New insights into the bioavailability and hepatoxicity risk of neonicotinoids

Technical advances expand the application of mass spectrometry imaging in pharmaceutical research

Insulin-like peptide 3 may be a predictor of hypogonadism and age-associated morbidity in older males

Horizontal gene transfer from mother to infant influences gut microbiome assembly, neurodevelopment, and immune maturation in infants

Scientists explore synthesis of griffithsin in cell-free systems

DISCO-MS technology enables the study of diseases at their earliest stages

Study identifies four new monoclonal antibodies with broad neutralizing potencies that target conserved SARS-CoV-2 epitopes

Scientists suggest vibrational spectroscopy and nuclear magnetic resonance to evaluate drug concentrations

Sheep milk could be an inexpensive source of therapeutic polyclonal SARS-CoV-2 neutralizing antibodies

Polymorphisms in human immunoglobulin heavy chain genes can influence the function of SARS-CoV-2 neutralizing antibodies

Study reveals the presence of metal particles in cannabis vape liquids

Immunopeptidome characters of human CoV-OC43-infected cells

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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