Spleen News and Research

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Vesicular stomatitis virus-based COVID vaccines demonstrate potent antiviral efficacy against SARS-CoV-2 variants

Scientists from the National Institutes of Health, USA, have recently demonstrated the immunogenicity and protective efficacy of two vesicular stomatitis virus (VSV)-based coronavirus disease 2019 (COVID-19) vaccines in hamsters.

6 Sep 2021

Will mRNA vaccine boosters be required for SARS-CoV-2 variants?

A new study shows that the highly effective mRNA Moderna vaccine designed against the original SARS-CoV-2 strain may lose some efficacy as new variants arise.

30 Aug 2021

Preclinical study validates crucial role of the spleen in cardiac repair

Although we can survive without a spleen, evidence continues to mount that this abdominal organ plays a more valuable role in our physiological defenses than previously suspected.

23 Aug 2021

Durable highly protective T cell response to AAV-spike vaccine against COVID-19 pneumonia in mice

New research, available as a preprint on the bioRxiv* server, has focused on the role played by T cell immunity, particularly CD8+ cytotoxic T cells, on preventing lethal infection with SARS-CoV-2 in mice infused with peptide-loaded antigen-presenting dendritic cells (DCs).

19 Aug 2021

UC Davis Health offers third dose COVID-19 'booster' shots to immunocompromised patients

As COVID-19 cases rise due to the Delta variant, the Centers for Disease Control (CDC) has approved third dose vaccinations for patients whose immune systems are compromised moderately to severely.

17 Aug 2021

Study demonstrates the potency of herbal medicines against Bartonella henselae

Bay Area Lyme Foundation, a leading sponsor of Lyme disease research in the U.S., today announced the publication of new data showing that herbal medicines have potent activity in test tubes compared to pharmaceuticals commonly-prescribed for the treatment of Bartonella henselae, a bacterium believed to be carried by ticks and the cause of cat scratch fever.

5 Aug 2021

Vaccinia-based COVID-19 vaccines confer immunity in hamster model

In a paper recently uploaded to the preprint server bioRxiv* by Kulkarni et al. (August 3, 2021), the potential of vaccinia virus-based vaccines expressing the full-length SARS-CoV-2 spike protein is examined in mice and Syrian hamsters. The findings report that the vaccine generates high titers of neutralizing antibodies with good activity towards SARS-CoV-2 variants of concern.

5 Aug 2021

Study shows COVID-19 organ-specific outcomes depend on anti-spike glycoprotein antibodies

A recent study from the University of Rochester reveals how the biodistribution kinetics and the affinity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for many different organs in the human body can be affected by antibodies targeting viral spike glycoprotein. The paper is currently available on the bioRxiv* preprint server while it undergoes peer review.

3 Aug 2021

MUSC Hollings Cancer Center part of promising phase 2 lymphoma clinical trial

MUSC Hollings Cancer Center was one of 28 clinical sites around the world that participated in the LOTIS-2 trial to test the efficacy of Loncastuximab tesirine, a promising new treatment for aggressive B-cell lymphoma.

23 Jul 2021

Potent nasal vaccine protects non-human primates from SARS-CoV-2

A team of US-based scientists has recently demonstrated the efficacy of a live attenuated, recombinant coronavirus disease 2019 (COVID-19) vaccine candidate currently under phase I clinical trial as a single-dose intranasal vaccine.

20 Jul 2021

UCSF researchers discover how the immune system may play a role in miscarriage

Researchers at UC San Francisco are zeroing in on how the immune system may play a role in miscarriage, which affects about a quarter of pregnancies.

16 Jul 2021

Common artificial sweeteners can lead to serious health issues

New research has discovered that common artificial sweeteners can cause previously healthy gut bacteria to become diseased and invade the gut wall, potentially leading to serious health issues.

24 Jun 2021

Researchers screen Chinese herbal medicines and plant compounds for anti-SARS-CoV-2 activity

A review published in Phytotherapy Research discussed the natural anti-SARS-CoV-2 products identified based on in silico prediction. The review’s authors also illustrate the impact of many phytochemicals either alone or in combination with traditional treatments and their potential molecular mechanisms involved in SARS-CoV-2 prevention and treatment.

22 Jun 2021

Mast cell activation may underlie inflammation in severe COVID-19

A new preprint research paper posted to the medRxiv* server points to mast cells as major culprits in the etiology of severe and critical COVID-19. This could suggest suitable therapeutic and preventive interventions to reduce the morbidity and mortality of this viral illness.

3 Jun 2021

Malaria parasites may survive, replicate within the spleen of asymptomatic individuals, study suggests

Malaria, a disease caused mainly by the parasites Plasmodium falciparum and Plasmodium vivax, (P. vivax) is associated with over 400,000 deaths each year.

1 Jun 2021

Vagus nerve stimulation may be a potential adjunct therapy for COVID-19

COVID-19 was initially described as lung inflammation, or pneumonia, in older adults. However, we now know that SARS-CoV-2 infections can cause a wide range of symptoms in people of all ages, ranging from no symptoms at all to systemic inflammation and even death.

27 May 2021

Spleen News and Research

Vesicular stomatitis virus-based COVID vaccines demonstrate potent antiviral efficacy against SARS-CoV-2 variants

Will mRNA vaccine boosters be required for SARS-CoV-2 variants?

Preclinical study validates crucial role of the spleen in cardiac repair

Durable highly protective T cell response to AAV-spike vaccine against COVID-19 pneumonia in mice

UC Davis Health offers third dose COVID-19 'booster' shots to immunocompromised patients

Study demonstrates the potency of herbal medicines against Bartonella henselae

Vaccinia-based COVID-19 vaccines confer immunity in hamster model

Study shows COVID-19 organ-specific outcomes depend on anti-spike glycoprotein antibodies

MUSC Hollings Cancer Center part of promising phase 2 lymphoma clinical trial

Potent nasal vaccine protects non-human primates from SARS-CoV-2

UCSF researchers discover how the immune system may play a role in miscarriage

Common artificial sweeteners can lead to serious health issues

Researchers screen Chinese herbal medicines and plant compounds for anti-SARS-CoV-2 activity

Mast cell activation may underlie inflammation in severe COVID-19

Malaria parasites may survive, replicate within the spleen of asymptomatic individuals, study suggests

Vagus nerve stimulation may be a potential adjunct therapy for COVID-19

Next-generation SARS-CoV-2 subunit vaccine candidate elicits powerful immunity in preclinical trials

Milder COVID-19 in children may be due to higher memory B cells responses to SARS-CoV-2

Researchers use ultrasound to reduce COVID-19-related inflammation

Blocking fat-busting enzyme with a drug compromises cardiac repair during acute heart failure

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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