Spleen News and Research

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Researchers investigate Zika virus and Dengue virus co-immunity

In a new study, researchers successfully created new strains of the Zika virus and proved that the process of passaging through mice resulted in significantly increased virulence.

19 Apr 2022

Exploring strategies for successful delivery of messenger RNA therapeutics

Researchers reviewed the material properties and administration routes that could successfully deliver a messenger ribonucleic acid therapeutic agent to its targeted site.

14 Apr 2022

Recent advances in non-viral nano-vector delivery of CRISPR/Cas9 genome editing payloads

Researchers reviewed non-viral nano-vectors used for delivering the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9-mediated genome editing system.

14 Apr 2022

Novel transdermal vaccine delivery for COVID-19 and cancer

Researchers assess the efficacy of a fluorocarbon modified chitosan system for the development of SARS-CoV-2 vaccines and tumor immunotherapy.

13 Apr 2022

Study explores incidence of cardiac impairment a year after SARS-CoV-2 infection

Researchers used cardiac magnetic resonance to show the one-year trajectory of cardiac impairment in long coronavirus disease patients.

6 Apr 2022

Chemical in leafy greens could prevent infections by coronaviruses including SARS-CoV-2

Researchers discuss the use of the isothiocyanate sulforaphane for the treatment of both SARS-CoV-2 and HCoV-OC43 infections.

30 Mar 2022

Divalent SARS-CoV-2 fusion vaccine found to be effective in mice

Researchers bioengineered a divalent fusion vaccine by combining the immunogenic region of the nucleocapsid protein and the receptor-binding domain of the spike protein of SARS-CoV-2.

30 Mar 2022

Preclinical investigation of intranasal adjuvanted COVID-19 vaccine

A new study reported systemic and mucosal immunity against SARS-CoV-2 via intranasal delivery of a vaccine containing recombinant SARS-CoV-2 antigens, nucleocapsid, and spike subunit.

30 Mar 2022

Tuberculosis infection protects mice against COVID-19

To study if prior Mtb infection affects the response to CoV2 infection, K18-hACE2 (ACE2) and C57BL/6 (B6) mice were infected with Mtb, and post thirty days, were exposed to CoV2.

27 Mar 2022

Prevalence of organ impairment in Long COVID patients 6 and 12 months after initial symptoms

Researchers assessed the prevalence of organ impairment in long COVID six months and a year post-COVID-19 at London and Oxford.

24 Mar 2022

Presence of zoonotic pathogens in wildlife market for human consumption in Laos

Researchers from different countries examined various animal species from wildlife trade sites to detect the presence of zoonotic pathogens in Laos, South East Asia.

18 Mar 2022

Innate and adaptive immune responses to BNT162b2 vaccination in mice

Researchers analyzed the innate and adaptive responses to the mRNA-based BNT162b2 COVID-19 vaccine in mice.

18 Mar 2022

Study reports reduced disease severity in Syrian hamsters during re-infection with SARS-CoV-2 Delta variant

Researchers studied the immune responses in Syrian hamsters re-infected with SARS-CoV-2 Delta and B.1 variants three months after the primary infection.

17 Mar 2022

NETosis in COVID-19 and MIS-C

A new study investigates the role played by neutrophil extracellular traps formation and degradation in COVID-19.

7 Mar 2022

Omicron-specific mRNA vaccine generates immune responses in mice, hamsters and Macaques

Researchers develop an Omicron variant mRNA vaccine that is be more potent in generating nAbs as compared to other available vaccines.

6 Mar 2022

Adenosine receptor agonists provide therapeutic target in mouse SARS-CoV-2 infection

A new study describes the efficacy of adenosine receptor agonists in the treatment of SARS-CoV-2 infection.

2 Mar 2022

New type of drug delivery vehicle mimics the properties of a red blood cell

From the liver to the kidneys to the lungs, the human body is equipped with many levels of filters, which protect the body from harmful outside materials. But this system also has its downsides. Critically important drugs such as chemotherapy or multiple sclerosis treatments are also foreign materials, so the body filters out a large portion of these drugs – up to 90%, in some cases.

2 Mar 2022

Spleen News and Research

Researchers investigate Zika virus and Dengue virus co-immunity

Exploring strategies for successful delivery of messenger RNA therapeutics

Recent advances in non-viral nano-vector delivery of CRISPR/Cas9 genome editing payloads

Novel transdermal vaccine delivery for COVID-19 and cancer

Study explores incidence of cardiac impairment a year after SARS-CoV-2 infection

Chemical in leafy greens could prevent infections by coronaviruses including SARS-CoV-2

Divalent SARS-CoV-2 fusion vaccine found to be effective in mice

Preclinical investigation of intranasal adjuvanted COVID-19 vaccine

Tuberculosis infection protects mice against COVID-19

Prevalence of organ impairment in Long COVID patients 6 and 12 months after initial symptoms

Presence of zoonotic pathogens in wildlife market for human consumption in Laos

Innate and adaptive immune responses to BNT162b2 vaccination in mice

Study reports reduced disease severity in Syrian hamsters during re-infection with SARS-CoV-2 Delta variant

NETosis in COVID-19 and MIS-C

Omicron-specific mRNA vaccine generates immune responses in mice, hamsters and Macaques

Adenosine receptor agonists provide therapeutic target in mouse SARS-CoV-2 infection

New type of drug delivery vehicle mimics the properties of a red blood cell

COVID-19 severity is correlated with body composition

Researchers demonstrate the powerful gene silencing effects of HDO technology

Tiny lipid-based nanoparticles carry genetic instructions directly into the lungs

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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