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p53 activation suppresses malic enzyme expression and leads to senescence in pre-cancerous cells

It is perhaps impossible to overstate the importance of the tumor suppressor gene p53. It is the single most frequently mutated gene in human tumors. p53 keeps pre-cancerous cells in check by causing cells, among other things, to become senescent - aging at the cellular level. Loss of p53 causes cells to ignore the cellular signals that would normally make mutant or damaged cells die or stop growing.

16 Jan 2013

Viewpoints: Health law's 'sticker shock;' Changing Medicare eligibility age is not a simple solution

President Obama said a fair bit during the fiscal-cliff negotiations-;speaking for 45 minutes in one 50-minute meeting, for example-;but today let's zero in on the claim he kept repeating: "We don't have a spending problem. We have a health-care problem." For our money-;and yours-;those are two of the most remarkable sentences our Orator in Chief has ever strung together.

15 Jan 2013

Obese youngsters at far greater risk than had been supposed

While a great deal of research on childhood obesity has spotlighted the long-term health problems that emerge in adulthood, a new UCLA study focuses on the condition's immediate consequences and shows that obese youngsters are at far greater risk than had been supposed.

15 Jan 2013

Obesity complicates kidney transplantation

The risk for delayed graft function in patients undergoing kidney transplant rises in line with their body mass index, say US researchers.

14 Jan 2013

Complications of suppurative otitis media characterized

Researchers emphasize the importance of an early and accurate diagnosis of chronic suppurative otitis media followed by surgical therapy to prevent complications.

14 Jan 2013

Blocking interaction of JNK enzyme may counteract neuron destruction

Oxidative stress is a primary villain in a host of diseases that range from cancer and heart failure to Alzheimer's disease, Amyotrophic Lateral Sclerosis and Parkinson's disease.

11 Jan 2013

Several genes may control body-fat responses to fast-food diets

Researchers at UCLA say it's not just what you eat that makes those pants tighter - it's also genetics. In a new study, scientists discovered that body-fat responses to a typical fast-food diet are determined in large part by genetic factors, and they have identified several genes they say may control those responses.

10 Jan 2013

Metabolic stress can increase onset of atrial fibrillation

Researchers have found new evidence that metabolic stress can increase the onset of atrial arrhythmias, such as atrial fibrillation (AF), a common heart condition that causes an irregular and often abnormally fast heart rate.

9 Jan 2013

New scoring system can help clinicians better identify non-ICU patients at risk for GI bleeding

Critically ill patients in hospital intensive care units (ICUs) are routinely prescribed acid-suppressive medications to reduce their risk of developing stress ulcers and gastrointestinal bleeding, both of which can result from being in a stressful environment and from being intubated. Over the years, this routine practice has often been extended to patients outside the ICU, despite a lack of evidence that this population is at significant risk of these complications.

9 Jan 2013

Lifting the burden of vascular disease

African-American men could improve their vascular health by lifting weights, researchers say.

8 Jan 2013

Adolescents may lose hepatitis B virus protection despite vaccination as infants

New research reveals that a significant number of adolescents lose their protection from hepatitis B virus (HBV) infection, despite having received a complete vaccination series as infants. Results in the January 2013 issue of Hepatology, a journal published by Wiley on behalf of the American Association for the Study of Liver Diseases, suggest teens with high-risk mothers (those positive for HBeAg) and teens whose immune system fails to remember a previous viral exposure (immunological memory) are behind HBV reinfection.

8 Jan 2013

State roundup: Mo. lawmakers look to cap malpractice awards

A selection of health policy stories from California, Minnesota, Missouri, New York, Texas, Illinois and North Carolina.

8 Jan 2013

Complications of suppurative otitis media characterized

Researchers emphasize the importance of an early and accurate diagnosis of chronic suppurative otitis media followed by surgical therapy to prevent complications.

7 Jan 2013

Edison Pharmaceuticals to commence EPI-743 phase 2B Friedreich's ataxia study

Edison Pharmaceuticals today announced the initiation of a phase 2B study entitled, "Safety and Efficacy Study of EPI-743 on Visual Function in Patients with Friedreich's Ataxia."

7 Jan 2013

Training can improve inpatient record documentation

The accuracy and completeness of inpatient medical records can be significantly improved with clinical interventions designed to develop quality record keeping, research shows.

4 Jan 2013

Local conjunctival metastases ‘may be under-recognized’

Local conjunctival metastases may represent under-recognized lesions arising from the dissemination of primary conjunctival melanoma via local vessels, suggest findings published in the British Journal of Ophthalmology.

4 Jan 2013

Study reveals large microbial diversity in breast milk

Spanish researchers have traced the bacterial microbiota map in breast milk, which is the main source of nourishment for newborns. The study has revealed a larger microbial diversity than originally thought: more than 700 species.

4 Jan 2013

Markey practitioner receives Lexington Cancer Foundation grant to continue JSJ program

The University of Kentucky Markey Cancer Center's Jennifer Bradley has received funding from the Lexington Cancer Foundation to continue the Jin Shin Jyutsu program in 2013.

4 Jan 2013

Top 4 reasons why many dieters do not lose weight

The battle of the bulge is on - any movement on the scale yet? "Losing weight is one of the top resolutions made every year, yet only 20 percent of people achieve successful weight-loss and maintenance," says Jessica Bartfield,MD, internal medicine who specializes in nutrition and weight management at the Loyola Center for Metabolic Surgery & Bariatric Care.

4 Jan 2013

Calphotin essential in keeping cellular calcium concentration low

All living cells keep their cellular calcium concentration at a very low level. Since a small increase in calcium can affect many critical cellular functions (an elevated calcium concentration over an extended period can induce cell death), powerful cellular mechanisms ensure that calcium concentration quickly returns to its low level.

4 Jan 2013