Structural Biology News and Research

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Scientists develop new accurate computational method to enhance drug target stability

Scientists from the Moscow Institute of Physics and Technology, the Skolkovo Institute of Science and Technology, and the University of Southern California have developed a new computational method for the design of thermally stable G protein-coupled receptors that are of great help in creating new drugs.

30 Mar 2019

Study uncovers potential new strategy to treat influenza A

A team of researchers from Scripps Research and Janssen Research & Development LLC has discovered an orally active small molecule that neutralizes influenza A group 1 viruses, the most common flu strains.

11 Mar 2019

Researchers develop method for rapidly measuring proteins' unique vibrations

In the cells of every living organism -- humans, birds, bees, roses and even bacteria -- proteins vibrate with microscopic motions that help them perform vital tasks ranging from cell repair to photosynthesis.

5 Mar 2019

Research reveals how metabolites can be used to inhibit epigenetic mechanisms and treat MS

Understanding and mitigating the role of epigenetics (environmental influences that trigger changes in gene expression) in disease development is a major goal of researchers.

28 Feb 2019

Structure of human type 2 cannabinoid receptor revealed

A Chinese research team joined forces with Russian and U.S. biologists to obtain the crystal structure of the human type 2 cannabinoid receptor.

28 Feb 2019

UVA scientist receives $1 million award to map out submicroscopic world

A scientist at the University of Virginia School of Medicine has received a prestigious three-year, $1 million award from the William M. Keck Foundation to develop a new and better way to map out the submicroscopic world.

22 Feb 2019

New design guidance could advance development of disease-sensing nanomaterials

Scientists have long sought to develop drug therapies that can more precisely diagnose, target and effectively treat life-threatening illness such as cancer, cardiovascular and autoimmune diseases.

22 Feb 2019

Johns Hopkins scientists find new compound that may prevent reperfusion injury

In a strategic search, Johns Hopkins scientists created and screened a library of 45,000 new compounds containing chemical elements of widely used immune system suppressants, and say they found one that may prevent reperfusion injury, a tissue-damaging and common complication of surgery, heart attack and stroke.

21 Feb 2019

Scientists join forces to identify a new approach to fight African sleeping sickness

Scientists working in a range of disciplines joined forces to identify a new approach to combat African sleeping sickness. Fundamental research undertaken under the supervision of Professor Ute Hellmich of Johannes Gutenberg University Mainz has revealed a promising strategy to develop a suitable agent.

20 Feb 2019

Researchers identify suicide toxin in the bacteria responsible for tuberculosis

The bacteria responsible for tuberculosis can be killed by a toxin they produce unless it is neutralized by an antidote protein. The European team of scientists behind this discovery is coordinated by researchers from the Institute of Pharmacology and Structural Biology and the European Molecular Biology Laboratory.

18 Feb 2019

Researchers design interleukin protein to balance overshooting immune response

Small infections can be fatal: Millions of people die each year from sepsis, an overreaction of the immune system.

23 Jan 2019

Synthetic compound reverses mutant p53 aggregate accumulation, study shows

Cancer is a multidisciplinary disease, with different mutations leading to different prognoses and treatment necessities. Among the most important mutation targets in cancers, affecting more than 50% of all cancer cases, is TP53.

14 Jan 2019

Using Assay Kits and Dyes to Advance Cell Biology Research

In this interview, Richard Delle Bovi highlights live cell ability of the CELLESTIAL® analysis kit from Enzo Life Sciences and its applications in cell biology.

From Enzo Life Sciences, Inc. 2 Jan 2019

Novel insight on inflammatory regulation could pave way for effective pain therapies

A novel way in which the inflammatory response to pain is regulated has been described in the open-access journal eLife.

19 Dec 2018

New study could fine-tune the CRISPR gene editing process

The introduction of the tool for gene editing, the so-called gene scissors CRISPR, in 2007 was a revolution within medical science and cell biology.

30 Nov 2018

New Mainz-based Collaborative Research Center aims to explore DNA repair and genome stability

From January 1, 2019, the German Research Foundation will be funding the new Collaborative Research Center 1361 on Regulation of DNA Repair & Genome Stability.

29 Nov 2018

Research reveals how a small molecule helps remove excess cholesterol

Scientists have determined the structure of the activated form of an enzyme that helps to return excess cholesterol to the liver, a study in eLife reports.

27 Nov 2018

Scientists report novel combination transport system in E. coli

A general concept in biology is that cells use two different systems to transport substances across their membrane: selective pores, which allow passive transport driven by a concentration gradient, and active transport complexes, which use energy to transport substances against a gradient.

27 Nov 2018

Researchers provide new insights into regulation of important intracellular messenger molecule

The team of prof. Joris Messens at the VIB-VUB Center for Structural Biology has provided new insights into the regulation of an important intracellular messenger molecule, hydrogen peroxide (H2O2), whose dysregulation has been linked to the development of several diseases, including cancer.

22 Nov 2018

Researchers for first time view serotonin activating its receptor using high-powered microscopes

Serotonin receptors are common drug targets in the treatment of pain, gastrointestinal dysfunctions, and mood disorders yet little is known about their three-dimensional structure.

2 Nov 2018