Synapse News and Research

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Discovery of the novel Fragile X granule could lead to new autism treatment

A Brown University research team has discovered something in the brain that could serve as a target for future autism and mental retardation treatments.

5 Feb 2009

Discovery of mechanism for dental pain

Researchers at Oregon Health & Science University's School of Dentistry have discovered a novel function of the peptide known as Nerve Growth Factor (NGF) in the development of the trigeminal nerve.

8 Jan 2009

Decreased levels of binding gene affect memory and behavior

Reducing the activity of a gene called FKBP12 in the brains of mice affected neuron-to-neuron communication (synapse) and increased both fearful memory and obsessive behavior, indicating the gene could provide a target for drugs to treat diseases such as autism spectrum disorder, obsessive-compulsive disease and others, said researchers from Baylor College of Medicine in Houston in a report in the current issue of the journal Neuron.

10 Dec 2008

Nitric oxide can change computational ability of the brain

Research from the Medical Research Council (MRC) Toxicology Unit at the University of Leicester shows that nitric oxide (NO) can change the computational ability of the brain.

26 Nov 2008

A link found between nicotine addiction and autism

Scientists have identified a relationship between two proteins in the brain that has links to both nicotine addiction and autism.

17 Nov 2008

Forgotten but not gone - how the brain takes care of things

Thanks to our ability to learn and to remember, we can perform tasks that other living things can not even dream of.

17 Nov 2008

Scientists gain insight into the cause and possible treatment of motor neurone disease

BBSRC-funded researchers at UCL along with collaborators at King's College London have identified a molecule that could be the key to understanding the cause of neurodegenerative diseases such as motor neurone disease (MND).

17 Nov 2008

Vigabatrin offers hope for treating relapse to methamphetamine abuse

A new study at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory suggests that vigabatrin (a.k.a. gamma vinyl-GABA, or GVG) blocks drug-seeking behavior in animals previously trained to associate methamphetamine with a particular environment.

16 Nov 2008

Addiction drug Vigabatrin proves successful in animal weight loss study

Vigabatrin, a medication proposed as a potential treatment for drug addiction by scientists at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory, also leads to rapid weight loss and reduced food intake according to a new animal study from the same research group.

20 Aug 2008

Brain food - what we eat affects our intelligence

New research findings published online in The FASEB Journal provide more evidence that if we get smart about what we eat, our intelligence can improve. According to MIT scientists, dietary nutrients found in a wide range of foods from infant formula to eggs increase brain synapses and improve cognitive abilities.

2 Jul 2008

FDA approves implantable electronic device that stimulates the diaphragm

The U.S. Food and Drug Administration has announced that it approved the NeuRx DPS RA/4 Respiratory Stimulation System, an implantable electronic device that stimulates the diaphragm and allows certain spinal cord injury patients to breathe for at least four hours a day without a mechanical ventilator.

19 Jun 2008

Cephalopod research helps show how our brains store and recall memory

Research on octopuses has shed new light on how our brains store and recall memory, says Dr. Benny Hochner of the Department of Neurobiology at the Alexander Silberman Institute of Life Sciences at the Hebrew University of Jerusalem.

17 Jun 2008

Discovery of mechanisms that direct cholinergic synapse assembly between neurons in vivo

Rapid information processing in the nervous system requires synapses, specialized contact sites between nerve cells and their targets. One particular synapse type, cholinergic, uses the chemical transmitter acetylcholine to communicate between nerve cells. Cholinergic synapses are essential for normal learning and memory, arousal, attention, and all autonomic (involuntary) nervous system functions.

16 Jun 2008

Complex synapses drove brain evolution

One of the great scientific challenges is to understand the design principles and origins of the human brain. New research has shed light on the evolutionary origins of the brain and how it evolved into the remarkably complex structure found in humans.

8 Jun 2008

Discovery of a molecular scaffold that guides connections between brain cells

Brain cells known as neurons process information by joining into complex networks, transmitting signals to each other across junctions called synapses. But "neurons don't just connect to other neurons," emphasizes Z. Josh Huang, Ph.D., "in a lot of cases, they connect to very specific partners, at particular spots."

21 May 2008

Discovery of mechanism of action of antibiotic able to reduce neuronal cell death in brain

Virginia Commonwealth University researchers have discovered how an antibiotic works to modulate the activity of a neurotransmitter that regulates brain functions, which eventually could lead to therapies to treat Alzheimer's disease, Huntington's disease, epilepsy, stroke, dementia and malignant gliomas.

11 May 2008

Killer competition: neurons duke it out for survival!

The developing nervous system makes far more nerve cells than are needed to ensure target organs and tissues are properly connected to the nervous system. As nerves connect to target organs, they somehow compete with each other resulting in some living and some dying.

6 May 2008

New discovery on how memory is stored

Researchers at Wake Forest University School of Medicine are the first to show that the location of protein-destroying "machines" in nerve cells in the brain may play an important role in how memories are formed - a finding with potential implications for treating Alzheimer's and other brain diseases. The research is published in the current issue of Learning & Memory.

23 Apr 2008

Discovery of role of rare gene mutations in schizophrenia

Using an important new method that can be applied in the study of other psychiatric illnesses, scientists at Cold Spring Harbor Laboratory (CSHL) in collaboration with colleagues at the University of Washington (UW) and the National Institute of Mental Health (NIMH), have identified multiple, individually rare gene mutations in people with schizophrenia that may help explain how that devastating illness is caused.

31 Mar 2008

Two-way cell talk provides clues about neuromuscular disease

It's a scientific given that neurons tell other cells what to do, but new evidence suggests that, like with any good relationship, these target cells also have much to contribute, scientists say.

17 Feb 2008