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The biochemical mechanisms of remdesivir-mediated RNA synthesis inhibition

A new preprint suggests a fruitful approach to develop such drugs based on biochemical and molecular modeling studies of the drug remdesivir.

19 Oct 2021

COVID-19 vaccine breakthrough infections among immunocompromised individuals

A study of breakthrough infections in immunocompromised people following two doses of the Pfizer/BioNTech vaccine against SARS-CoV-2 concluded that immunocompromised people would be best served with a third dose of the vaccine for better protection.

19 Oct 2021

Factors impacting mental health and wellbeing of long covid patients

A new preprint deals with the mental baggage accompanying this condition, often termed “long covid.”

19 Oct 2021

Phase 2 trial shows COVID-19 recombinant protein vaccine elicits promising immunogenicity responses

Researchers performed a large-scale, double-blind, placebo-controlled phase two trial to assess the efficacy, safety, and immune response elicited from vaccination with MVC-COV1901.

19 Oct 2021

SARS-CoV-2 mutations amplify its advantage over host for efficient translation of viral RNAs

A study shows that mutations that SARS-CoV-2 has gained improve its advantage in the efficient translation of viral RNAs.

19 Oct 2021

Structural mechanism of anti-SARS-CoV-2 neutralizing antibodies that target separate spike epitopes

Researchers from the Washington University School Of Medicine have identified how a subset of variants of concern can escape neutralization by two neutralizing antibodies.

19 Oct 2021

Nasal delivery of single-domain antibodies improves SARS-CoV-2 symptoms in animal model

In a recent study published in the journal PLOS Pathogens, scientists showed that nasal administration of a single-domain antibody (VHH), named K-874A, brought about inhibition of SARS-CoV-2 titers in infected lungs of Syrian hamsters.

19 Oct 2021

Scientists scan 110 natural compounds for SARS-CoV-2 antiviral potential

Phytochemicals are plant-derived molecules from medicinal plants that act as a prominent reservoir for treating a wide range of viral infections. In a new study, published in the journal Scientific Reports, scientists adopted a computational approach to identify Mpro inhibitors.

19 Oct 2021

Waning COVID vaccine efficacy especially against reinfection

A new study in American veterans posted to the medRxiv* preprint server suggests severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are less effective in preventing infection after six months. The decline was most significant with the Johnson & Johnson vaccine, with vaccine effectiveness plummeting from 88% to 3%.

19 Oct 2021

SARS-CoV-2 antibodies detected in breast milk of vaccinated mothers

Now, a new medRxiv* preprint study finds mothers vaccinated either one of the messenger RNA (mRNA) vaccines transferred neutralizing antibodies and cytokines, including interferon-gamma (IFNγ), to a breastfeeding child. Additionally, the humoral response in breastmilk was effective in neutralizing four variants of concern.

18 Oct 2021

Many people's T-cells recognize the same components of SARS-CoV-2

A new study published on the bioRxiv* preprint aimed to identify highly immunoprevalent CD8 T-cell epitopes specific to SARS-CoV-2 that are confirmed to be endogenously processed and presented on frequently expressed HLA alleles.

18 Oct 2021

Modelling suggests fall in acute admissions with mass COVID-19 vaccinations

A new study explores the utility of modeling the impact of mass vaccination on the number of hospital beds occupied by acute COVID-19 cases.

18 Oct 2021

Telehealth to the rescue for children’s mental health during COVID

A new study concludes that the lack of transportation led to impairments in child mental health services.

18 Oct 2021

Factors contributing to a weak antibody response to the Pfizer COVID-19 vaccine

A new study discusses risk factors for the failure of seroconversion following full vaccination with the COVID-19 Pfizer vaccine.

18 Oct 2021

Famous scientist joins NYU Langone’s Division of Rheumatology

Nationally recognized for his work studying a novel inflammatory disorder known as VEXAS, David B. Beck, MD, PhD, has joined the Division of Rheumatology at NYU Langone.

18 Oct 2021

Study shows enhanced immunogenicity of heterologous boosting strategy in individuals primed with J&J vaccine

Researchers from Singapore conducted a study to assess the spike protein-specific humoral and cellular immunity in Ad26.COV2.S vaccinated individuals either primed with Ad26.COV2.S only, or boosted with a homologous or heterologous second dose.

18 Oct 2021

How can framing COVID-19 vaccine side-effects affect an individual's willingness to be vaccinated?

Researchers from the University of Munich have investigated how framing vaccine side-effects can affect an individual's willingness to be vaccinated.

18 Oct 2021

Study assesses T-cell responses directed against highly conserved regions of SARS-CoV-2

The study aimed to assess whether highly conserved regions within coronaviruses harbor CD8+ T-cell epitopes, capable of being cross-recognized between different coronaviruses.

18 Oct 2021

Study finds vaccination confers protection against SARS-CoV-2 onward transmission

The research group reports on the waning effectiveness of the COVID-19 vaccines against transmission to household contacts in the face of these relaxed measures and more transmissible strains of SARS-CoV-2.

18 Oct 2021

Inhibition of SARS-CoV-2 helicase by single DNA lesions

In a paper, the impact of specific DNA lesions is investigated regarding the unwinding activity of NSP13.

18 Oct 2021

Syndrome News and Research

The biochemical mechanisms of remdesivir-mediated RNA synthesis inhibition

COVID-19 vaccine breakthrough infections among immunocompromised individuals

Factors impacting mental health and wellbeing of long covid patients

Phase 2 trial shows COVID-19 recombinant protein vaccine elicits promising immunogenicity responses

SARS-CoV-2 mutations amplify its advantage over host for efficient translation of viral RNAs

Structural mechanism of anti-SARS-CoV-2 neutralizing antibodies that target separate spike epitopes

Nasal delivery of single-domain antibodies improves SARS-CoV-2 symptoms in animal model

Scientists scan 110 natural compounds for SARS-CoV-2 antiviral potential

Waning COVID vaccine efficacy especially against reinfection

SARS-CoV-2 antibodies detected in breast milk of vaccinated mothers

Many people's T-cells recognize the same components of SARS-CoV-2

Modelling suggests fall in acute admissions with mass COVID-19 vaccinations

Telehealth to the rescue for children’s mental health during COVID

Factors contributing to a weak antibody response to the Pfizer COVID-19 vaccine

Famous scientist joins NYU Langone’s Division of Rheumatology

Study shows enhanced immunogenicity of heterologous boosting strategy in individuals primed with J&J vaccine

How can framing COVID-19 vaccine side-effects affect an individual's willingness to be vaccinated?

Study assesses T-cell responses directed against highly conserved regions of SARS-CoV-2

Study finds vaccination confers protection against SARS-CoV-2 onward transmission

Inhibition of SARS-CoV-2 helicase by single DNA lesions

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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