TDP 43 News and Research

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Scientists identify new compound that reverses ALS neuron damage

Northwestern University scientists have identified the first compound that eliminates the ongoing degeneration of upper motor neurons that become diseased and are a key contributor to ALS (amyotrophic lateral sclerosis), a swift and fatal neurodegenerative disease that paralyzes its victims.

23 Feb 2021

Researchers identify link between ALS and accumulation of DNA-RNA hybrids in the genome

Researchers from the University of Seville and the University of Pavia have identified a link between Amyotrophic Lateral Sclerosis (ALS) and the accumulation of DNA-RNA hybrids in the genome.

13 Jan 2021

Study reveals new biomarker for amyotrophic lateral sclerosis

ALS is a fatal neurodegenerative disease causing a rapid loss of motor function, which usually results in a serious condition with early death within a few years.

9 Dec 2020

New technique can detect TDP-43 protein in patients with ALS and frontotemporal dementia

A test to diagnose two very serious diseases such as ALS and FTD when the pathologies have not yet appeared, thereby providing doctors and patients with essential information tools to tackle them early and develop new treatments.

27 Oct 2020

ALS and FTLD result from reduced transportation of messenger RNA

The lack of protein TDP-43 in two neurodegenerative diseases is shown to prevent neuron growth via failed transport of RNA and subsequent absence of protein synthesis in axons

23 Sep 2020

Scientists unlock crucial molecular details regarding tau's activity

Frontotemporal lobar degeneration (FTLD) is a type of dementia that appears earlier in life than Alzheimer's disease (AD).

15 Sep 2020

Investigational drug may reduce protein buildup and neurological decline linked to ALS, FTD

An investigational drug that targets an instigator of the TDP-43 protein, a well-known hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), may reduce the protein's buildup and neurological decline associated with these disorders, suggests a pre-clinical study from researchers at Penn Medicine and Mayo Clinic.

8 Sep 2020

New criteria to differentiate between frontotemporal dementia and LATE disease

Working with their colleagues at the University of Pennsylvania, researchers at the University of Kentucky have found that they can differentiate between subtypes of dementia inducing brain disease.

24 Aug 2020

Study indicates a potential link between Alzheimer's and common brain disorder

Alzheimer's disease is one of the most common causes of dementia, and while most people might know someone who is affected by it, the genetic factors behind the disease are less known.

20 Aug 2020

Study highlights a complex and under-recognized form of dementia

The long-running study on aging and brain health at the University of Kentucky's Sanders-Brown Center on Aging Alzheimer's Disease Center has once again resulted in important new findings - highlighting a complex and under-recognized form of dementia.

27 Jun 2020

Link between ALS and Alzheimer's disease can help advance the search for new therapies

On the surface, amyotrophic lateral sclerosis (ALS) and Alzheimer's disease share two commonalities: Both are progressively debilitating neurodegenerative conditions--meaning symptoms get worse--and, at least for now, neither has an effective treatment, let alone a cure.

16 Jun 2020

Blue light illuminates key ALS pathologies in zebrafish

A joint research group in Japan has succeeded in reproducing key ALS symptoms in a small tropical fish by remote controlling a disease-associated protein molecule using light illumination.

26 Feb 2020

Supplementing diet with amino acid delays signs of ALS in animal study

The addition of dietary L-serine, a naturally occurring amino acid necessary for formation of proteins and nerve cells, delayed signs of amyotrophic lateral sclerosis in an animal study.

24 Feb 2020

Unexpected findings could lead to new therapeutic intervention for ALS

A therapeutic intervention for amyotrophic lateral sclerosis, better known as ALS or Lou Gehrig's disease, could be on the horizon thanks to unexpected findings by University of Arizona researchers.

11 Feb 2020

Research uncovers protective role of astrocytes in sporadic motor neuron disease

Support cells in the nervous system help protect motor neurons in the early-stages of sporadic motor neuron disease, according to new research from the Crick and UCL.

10 Feb 2020

Study identifies molecular 'bridge' between ALS-causing genes

The enzyme Gemin3 was identified as the molecular 'bridge' between genes whose mutation or disruption causes amyotrophic lateral sclerosis, according to a new study in Nature's Scientific Reports from scientists at the University of Malta.

16 Jan 2020

Declining dementia rates may be due to generational differences in lifetime lead exposure

To the medical community's surprise, several studies from the US, Canada, and Europe suggest a promising downward trend in the incidence and prevalence of dementia. Important risk factors for dementia, such as mid-life obesity and mid-life diabetes, have been increasing rapidly, so the decline in dementia incidence is particularly perplexing.

19 Dec 2019