Tamoxifen News and Research

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Tamoxifen is a drug used to treat certain types of breast cancer in women and men. It is also used to prevent breast cancer in women who have had ductal carcinoma in situ (abnormal cells in the ducts of the breast) and in women who are at a high risk of developing breast cancer. Tamoxifen is also being studied in the treatment of other types of cancer. It blocks the effects of the hormone estrogen in the breast. Tamoxifen is a type of antiestrogen. Also called tamoxifen citrate.

Researchers shine new light on a potential target for the treatment of diabetic nephropathy

The kidneys perform a critical role in the body by removing waste and excess fluid in the form of urine. In a condition known as diabetic nephropathy, complications from diabetes disrupt the ability of the kidneys to function properly.

15 Mar 2023

Exploring airway-to-brain sensory pathways in influenza-induced illness

In a recent study published in the Nature journal, researchers assessed the role of the airway-to-brain sensory pathways in influenza-induced illness.

13 Mar 2023

Racial disparities in use of preventive measures to thwart breast cancer

Black women at high risk of breast cancer face a variety of obstacles that may keep them from care that could prevent cancer and increase the chances they'll survive if they develop the disease, new research has found.

1 Mar 2023

The loss of epigenetic information accelerates the aging process

A new study in the journal Cell aimed to determine whether epigenetic changes are a cause of mammalian aging.

15 Jan 2023

Changing heart cell programming can reverse the lasting damage caused by heart attacks

Back in 1971, the Bee Gees asked, "How can you mend a broken heart?". Now, researchers from Japan reveal that they may just have found a way to repair cardiac damage in patients suffering from chronic heart attack and heart failure.

16 Dec 2022

Genomic assay can help identify breast cancer patients who may benefit from ovarian suppression therapy

Among premenopausal women with hormone receptor (HR)-positive, early-stage breast cancer enrolled in the SOFT trial, those with a high score on a genomic assay called Breast Cancer Index (BCI) had increased risk of distant recurrence, and those with low BCI benefited more from the addition of ovarian suppression therapy to endocrine therapy after 12 years of follow-up, according to data presented at the San Antonio Breast Cancer Symposium, held December 6-10, 2022.

7 Dec 2022

Molecular fate-mapping of antibodies shows effects of antigenic imprinting

In a new study, researchers developed a molecular fate-mapping method for differential detection of antibodies derived from specific B cell clones.

1 Sep 2022

Hormonal treatment provides long-term benefit for premenopausal women with breast cancer

To investigate the long-term benefit of hormone-lowering treatment, researchers at Karolinska Institutet in Sweden have done a 20-year follow-up of premenopausal women with breast cancer.

2 Aug 2022

Temporal changes in CD4 T-lymphocyte dynamics upon immunization against SARS-CoV-2 spike protein

Researchers assessed changes in CD4 T-lymphocyte temporal dynamics by evaluating T-lymphocyte responses to SARS-CoV-2 S using Foxp3-Tocky mice and Nr4a3-Tocky mice.

27 Jul 2022

New study looks at the role of beta cells in triggering autoimmunity

Research into the causes of type 1 diabetes often focuses on the autoimmune response, where the immune system destroys pancreatic islet beta cells that produce insulin.

28 Jun 2022

Breast cancer trial results may not translate to real-world outcomes based on treatment discontinuation

New research in the June 2022 issue of JNCCN-;Journal of the National Comprehensive Cancer Network raises issues with clinical trial findings that show adjuvant hormone therapy (AHT)-related hot flashes predict better outcomes for estrogen receptor-positive (ER+) breast cancer.

21 Jun 2022

Probiotic bacteria may enhance anti-cancer activities of tamoxifen to reduce ER+ breast cancer risk

Probiotic bacteria may enhance anti-cancer activities of the breast cancer drug tamoxifen and other endocrine-targeted therapies, which could help reduce the risk of estrogen receptive positive (ER+) breast cancer, suggests a new study presented Monday at ENDO 2022, the Endocrine Society's annual meeting in Atlanta, Ga.

13 Jun 2022

How new Insights into ESR1 Mutant Breast Cancers may lead to Novel Therapy Targets

In this interview, we speak to Steffi Oesterreich, PH.D., from the University of Pittsburgh, about how new insights into a gene mutation present in 20-30% of breast cancer recurrences may have a silver lining, leading to novel treatment opportunities.

9 May 2022

Mason scientists receive DOD funding for breast cancer prevention and treatment research

George Mason University College of Science announced a $1.57 million dollar grant from the Department of Defense to fund a transformative approach for breast cancer treatment developed by scientists in Mason's Center for Drug Discovery for Rare Diseases.

15 Mar 2022

Scientists identify a molecular regulator involved in resistance to breast cancer treatment

A team from the UNIGE has identified a potential target for restoring the efficacy of standard treatment in resistant patients.

10 Mar 2022

Fat-secreted molecule may cancel out the effects of common breast cancer treatment

Leptin, a molecule produced by fat cells, appears to cancel out the effects of the estrogen-blocking therapy tamoxifen, a drug commonly used to treat and prevent breast cancers, suggests a new study led by researchers from the Johns Hopkins Kimmel Cancer Center.

9 Nov 2021

Tamoxifen News and Research

Further Reading

Researchers shine new light on a potential target for the treatment of diabetic nephropathy

Exploring airway-to-brain sensory pathways in influenza-induced illness

Racial disparities in use of preventive measures to thwart breast cancer

The loss of epigenetic information accelerates the aging process

Changing heart cell programming can reverse the lasting damage caused by heart attacks

Genomic assay can help identify breast cancer patients who may benefit from ovarian suppression therapy

Molecular fate-mapping of antibodies shows effects of antigenic imprinting

Hormonal treatment provides long-term benefit for premenopausal women with breast cancer

Temporal changes in CD4 T-lymphocyte dynamics upon immunization against SARS-CoV-2 spike protein

New study looks at the role of beta cells in triggering autoimmunity

Breast cancer trial results may not translate to real-world outcomes based on treatment discontinuation

Probiotic bacteria may enhance anti-cancer activities of tamoxifen to reduce ER+ breast cancer risk

How new Insights into ESR1 Mutant Breast Cancers may lead to Novel Therapy Targets

Mason scientists receive DOD funding for breast cancer prevention and treatment research

Scientists identify a molecular regulator involved in resistance to breast cancer treatment

Fat-secreted molecule may cancel out the effects of common breast cancer treatment

Clinical trial shows no benefit of tamoxifen in treating deadly fungal meningitis

Specialized cells that keep the heart beating have ability to regenerate after birth, study reveals

Clinical dilemmas in breast cancer patients solved by newly approved PET imaging agent

Breast radiation after lumpectomy decreases incidence of ipsilateral breast recurrence for 'low risk' DCIS

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