Tamoxifen News and Research

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Tamoxifen is a drug used to treat certain types of breast cancer in women and men. It is also used to prevent breast cancer in women who have had ductal carcinoma in situ (abnormal cells in the ducts of the breast) and in women who are at a high risk of developing breast cancer. Tamoxifen is also being studied in the treatment of other types of cancer. It blocks the effects of the hormone estrogen in the breast. Tamoxifen is a type of antiestrogen. Also called tamoxifen citrate.

Fatty liver disease susceptibility: study identifies interaction between estrogen receptor and genetic variant in women

Researchers pursued evidence of whether the interaction between the patatin-like phospholipase domain-containing 3 p.I148M variant and the female sex at the genetic and molecular level explains why premenopausal women remain protected against fatty liver disease, while a rapidly progressive disease ensues in some peri- and postmenopausal women.

28 Sep 2023

UTSA researchers study the mechanism of action of Sweet Annie's medicinal compounds

Vibrant green leaves sprout from tall fragrant plants sitting neatly in two rows of terracotta pots in Valerie Sponsel's UTSA biology laboratory.

8 Sep 2023

Study finds ways to improve medication adherence in breast cancer survivors

For roughly 80% of breast cancer survivors, treatment doesn't end with surgery, radiation and chemotherapy. Instead, for the next five to 10 years, doctors recommend that they take medication to block sex hormones, which can fuel tumor growth and spark recurrence.

1 Sep 2023

Less is more: Radiotherapy omission deemed safe for certain breast cancer patients

The risk of breast cancer recurrence after breast-conserving surgery.

22 Aug 2023

Anti-estrogenic therapies can suppress growth of ER-negative cancers

Anti-estrogenic therapies can suppress the growth of cancer that does not express estrogen receptors; when combined with immune checkpoint inhibitor therapies, they halt tumor progression in mice models.

21 Aug 2023

The impact of epigenetic features on breast cancer treatment and outcomes

The impact of epigenetic features on breast cancer treatment and outcomes.

9 Aug 2023

Breast Cancer Now-funded research aims to improve quality of care for black women with breast cancer

Researchers are investigating how to improve the quality of care for black women with breast cancer and reduce health inequalities, thanks to funding from Breast Cancer Now.

2 Aug 2023

Study provides new insights into the intricate cellular processes driving heterotopic ossification

In a new study published on 21 July 2023 by the journal Bone Research, a team of researchers from Johns Hopkins University, using a combination of lineage tracing and single-cell RNA sequencing (scRNA-seq), delved into the contribution of synovial/tendon sheath progenitor cells to heterotopic bone formation.

1 Aug 2023

Study reveals molecular mechanisms of H. pylori-induced gastric carcinogenesis

Helicobacter pylori (H. pylori) infections are commonly associated with abdominal pain, bloating, and acidity. Clinical evidence suggests that infection with H. pylori cagA+ strains dramatically increases the risk of developing gastric cancer.

18 Jul 2023

Mark Cuban's Cost Plus Drug Company projects huge savings over Medicare for generic cancer medications

Researchers reveal significant cost savings when generic oncology drugs are purchased through the Mark Cuban Cost Plus Drug Company.

13 Jun 2023

A review of the risk factors associated with cancer evolution

Researchers reviewed existing data on tumor-promotive risk factors and their underlying mechanisms.

17 Apr 2023

Researchers shine new light on a potential target for the treatment of diabetic nephropathy

The kidneys perform a critical role in the body by removing waste and excess fluid in the form of urine. In a condition known as diabetic nephropathy, complications from diabetes disrupt the ability of the kidneys to function properly.

15 Mar 2023

Exploring airway-to-brain sensory pathways in influenza-induced illness

In a recent study published in the Nature journal, researchers assessed the role of the airway-to-brain sensory pathways in influenza-induced illness.

13 Mar 2023

Racial disparities in use of preventive measures to thwart breast cancer

Black women at high risk of breast cancer face a variety of obstacles that may keep them from care that could prevent cancer and increase the chances they'll survive if they develop the disease, new research has found.

1 Mar 2023

The loss of epigenetic information accelerates the aging process

A new study in the journal Cell aimed to determine whether epigenetic changes are a cause of mammalian aging.

15 Jan 2023

Changing heart cell programming can reverse the lasting damage caused by heart attacks

Back in 1971, the Bee Gees asked, "How can you mend a broken heart?". Now, researchers from Japan reveal that they may just have found a way to repair cardiac damage in patients suffering from chronic heart attack and heart failure.

16 Dec 2022

Genomic assay can help identify breast cancer patients who may benefit from ovarian suppression therapy

Among premenopausal women with hormone receptor (HR)-positive, early-stage breast cancer enrolled in the SOFT trial, those with a high score on a genomic assay called Breast Cancer Index (BCI) had increased risk of distant recurrence, and those with low BCI benefited more from the addition of ovarian suppression therapy to endocrine therapy after 12 years of follow-up, according to data presented at the San Antonio Breast Cancer Symposium, held December 6-10, 2022.

7 Dec 2022