Toxicogenomics News and Research

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Developing a synthetic pathology framework: A step towards replacing animal testing

Researchers establish AnimalGAN as a reliable alternative for generating synthetic pathology data.

10 Nov 2023

Scientists use new approach to analyze millions of chemical-gene interactions

A University of Massachusetts Amherst environmental health scientist has used an unprecedented objective approach to identify which molecular mechanisms in mammals are the most sensitive to chemical exposures.

30 Oct 2020

Scientists develop new approach to unravel toxic effects of multiple stressors

Genomic markers are the key in a new approach for assessing the toxic effects arising from exposure to multiple stressors.

11 Apr 2019

Newly developed approach efficiently assesses carcinogenicity of chemicals

Researchers from Boston University Schools of Medicine and Public Health have developed and evaluated a fast, accurate and cost-effective approach to assessing the carcinogenicity of chemicals--that is, whether exposure to a chemical increases a person's long-term cancer risk.

10 Apr 2019

Brazilian researchers identify genes linked to melanoma progression

When researchers at the University of São Paulo in Brazil treated human melanoma cell lines with a synthetic compound similar to curcumin, one of the pigments that give turmeric its orange color, they identified genes with altered expression in potentially invasive tumors and malignant cells resistant to chemotherapy.

6 Dec 2017

OECD publishes novel knowledge management tools for advancing non-animal testing methods

The Organisation for Economic Co-operation and Development has recently published the first five adverse outcome pathways (AOP), three of which have been developed by the European Commission's science and knowledge service, the Joint Research Centre.

30 Sep 2016

CTD helps scientists explore impact of environmental exposures on human health

Two new studies from a group at North Carolina State University give researchers new strategies for connecting environmental exposures to human health effects.

13 May 2016

Researchers update extensive toxicology database to track information about drugs toxic effects

Sometimes the cure can be worse than the disease. Pharmaceutical drugs are known for their potential side effects, and an important aspect of personalized medicine is to tailor therapies to individuals to reduce the chances of adverse events.

6 Dec 2013

Researchers develop computer program to evaluate, rank scientific articles

Keeping up with current scientific literature is a daunting task, considering that hundreds to thousands of papers are published each day. Now researchers from North Carolina State University have developed a computer program to help them evaluate and rank scientific articles in their field.

19 Apr 2013

Merck Serono, Compugen announce establishment of Neviah Genomics

Merck Serono, a division of Merck, Darmstadt, Germany, and Compugen Ltd. today announced the establishment of Neviah Genomics, a novel start-up company focused on the discovery and development of novel biomarkers for the prediction of drug-induced toxicity.

26 Jun 2012

NanoString launches nCounter Rat miRNA Expression Assay Kit

NanoString Technologies, Inc., a privately held provider of life science tools for translational research and developer of molecular diagnostics, today announced the availability of the nCounter Rat miRNA Expression Assay Kit for use on its nCounter Analysis System.

From NanoString Technologies 9 Aug 2011

Best practices for assessing toxicity during drug discovery process

Ingenuity® Systems, the leading provider of information solutions for life science researchers, today announced the release of the white paper, "Best Practices for Assessing Toxicity throughout the Drug Discovery Process: Toxicogenomics." The white paper is based on input from industry experts and shows how multidisciplinary toxicology teams in drug discovery can leverage toxicogenomics and IPA® for improved predictive toxicology and mechanistic toxicity analysis.

17 Aug 2010

Entelos, RegeneMed release iToxFX to screen novel compounds for potential toxicity issues

Entelos, Inc., a simulation and modeling company focused on human health, and RegeneMed, Inc., a tissue-based drug discovery and regenerative medicine company, announced today the release of iToxFX™.

8 Mar 2010

Toxicologists, environmental health scientists to discuss on safeguarding public health at SOT meeting

The government's leading toxicologists and environmental health scientists will share their latest scientific accomplishments, offer continuing education courses, discuss funding and training opportunities, receive input on future research priorities, and more, at the Society of Toxicology annual meeting.

5 Mar 2010

Global market for oncology drugs is forecast to reach $80 billion by 2050

New Medicine's Oncology KnowledgeBASE (nm/OK) residing at http://nmok.net became available on the Internet 10 years ago and, since then, the oncology field has evolved into one of the most challenging, complex and promising drug development sectors, both in terms of its potential contribution to medicine and to its market opportunities.

29 Jan 2010

Genomic technologies to identify toxic chemicals should be developed

A new report from the National Research Council recommends that government agencies enhance their efforts to incorporate genomic data into risk assessments of chemicals and medicines, and calls for a concerted effort to fully develop these methods' potential to protect public health.

10 Oct 2007

Technology for analyzing gene expression must be standardized

Technology for analyzing gene expression must be standardized among laboratories and across platforms around the world to support this age of human genome exploration, an Oregon Health & Science University researcher says.

29 May 2005

One step closer to personalized medical treatment

A new study by 64 renowned scientists may bring us one step closer to personalized medical treatment--that is, medical treatment tailored to each person's unique genetic make-up and medical condition.

22 Apr 2005

Scientists identify compounds that mimic calorie restriction

Investigators from an international consortium of research institutes, including the Johns Hopkins Bloomberg School of Public Health, have identified compounds that mimic the effects of a low calorie diet without changing the amount of essential nutrients.

11 Aug 2004

New statistical techniques for cancer diagnosis

CSIRO statisticians have developed a new way to subtype paediatric Acute Lymphoblastic Leukaemia (ALL), the most common form of cancer in children under 12.

9 Jun 2004