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Penn researchers provide new insights into how Notch drives growth of B-cell cancers

Notch is one of the most frequently mutated genes in chronic lymphocytic leukemia (CLL), the most common leukemia in adults in the United States. It is also often mutated in other common B cell tumors, such as mantle cell lymphoma.

23 Oct 2017

Study elucidates how obesity makes breast cancer more aggressive

Obesity leads to the release of cytokines into the bloodstream which impact the metabolism of breast cancer cells, making them more aggressive as a result. Scientists from Helmholtz Zentrum München, Technische Universität München, and Heidelberg University Hospital report on this in 'Cell Metabolism'. The team has already been able to halt this mechanism with an antibody treatment.

23 Oct 2017

Pharmacological stimulation of nicotinic receptor could be strategy to treat lung inflammation

It has been amply proven that smoking can cause serious diseases such as emphysema and cancer. A new study, however, shows that pharmacological stimulation of a specific type of nicotinic receptor in cells of the immune system could be a strategy to treat inflammatory lung disease.

20 Oct 2017

Penn researchers functionally dissect gene variant linked to FTLD

Seven years ago, Penn Medicine researchers showed that mutations in the TMEM106B gene significantly increased a person's risk of frontotemporal lobar degeneration (FTLD), the second most common cause of dementia in those under 65.

19 Oct 2017

New RNA switch achieves gene activation thousands of times better than nature

If scientists could precisely regulate gene expression, they could turn off the genes responsible for illness and disease and turn on those that enhance health and the immune system.

19 Oct 2017

Findings reveal how seizures can have lasting detrimental effects on memory

Although it's been clear that seizures are linked to memory loss and other cognitive deficits in patients with Alzheimer's disease, how this happens has been puzzling. In a study published in the journal Nature Medicine, a team of researchers reveals a mechanism that can explain how even relatively infrequent seizures can lead to long-lasting cognitive deficits in animal models.

16 Oct 2017

Researchers identify new molecular pathway that controls aging in worms

Investigators at Case Western Reserve University School of Medicine and University Hospitals Health System have identified a new molecular pathway that controls lifespan and healthspan in worms and mammals.

13 Oct 2017

New study maps human genome to healthy tissue functions and disease processes

Our genomes help to determine who we are - the countless variations between individuals that encode the complexity of tissues and functions throughout the body.

13 Oct 2017

MIT researchers develop new technique to screen for genes that protect against diseases

Using a modified version of the CRISPR genome-editing system, MIT researchers have developed a new way to screen for genes that protect against specific diseases.

12 Oct 2017

Calcium controls use of glucose by T cells to multiply and battle against infection, study finds

A calcium signal controls whether immune cells can use the nutrients needed to fuel their multiplication into a cellular army designed to fight invading viruses.

11 Oct 2017

Study provides insights into non-oncogenic addictions of tumors

Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) and UC San Diego have shown that tumors can ensure a more reliable nutrient supply by eliminating the p62 protein in surrounding stromal tissue.

9 Oct 2017

Change in epigenetic gene regulation by imprinting can trigger preeclampsia, study shows

Preeclampsia is the most dangerous form of hypertension during a pregnancy and can be fatal for both mother and child. Though it is known to originate in the placenta, the root causes remain largely a mystery.

6 Oct 2017

Study sheds light on complex process involved in development of sperm stem cells

New research from scientists at Huntsman Cancer Institute at the University of Utah and collaborators at University of Utah Health sheds light on the complex process that occurs in the development of human sperm stem cells.

5 Oct 2017

GW researcher awarded NIH grant to study how cocaine use affects HIV infection

Following studies showing that cocaine influences the replication and transcription of HIV, a researcher at the George Washington University School of Medicine and Health Sciences was awarded more than $2.3 million from the National Institutes of Health to look deeper into the involved molecular mechanisms that allow this effect to happen.

5 Oct 2017

MRI and ultrasound can detect fetal brain damage caused by Zika in utero

Clinicians managing Zika-affected pregnancies should use magnetic resonance imaging (MRI) in addition to standard ultrasound (US) because the more detailed MRI images can reveal more extensive areas of damage to the developing fetal brain, according to research presented during IDWeek 2017.

4 Oct 2017

Transcription News and Research

Penn researchers provide new insights into how Notch drives growth of B-cell cancers

Study elucidates how obesity makes breast cancer more aggressive

Pharmacological stimulation of nicotinic receptor could be strategy to treat lung inflammation

Penn researchers functionally dissect gene variant linked to FTLD

New RNA switch achieves gene activation thousands of times better than nature

Findings reveal how seizures can have lasting detrimental effects on memory

Researchers identify new molecular pathway that controls aging in worms

New study maps human genome to healthy tissue functions and disease processes

MIT researchers develop new technique to screen for genes that protect against diseases

Calcium controls use of glucose by T cells to multiply and battle against infection, study finds

Study provides insights into non-oncogenic addictions of tumors

Change in epigenetic gene regulation by imprinting can trigger preeclampsia, study shows

Study sheds light on complex process involved in development of sperm stem cells

GW researcher awarded NIH grant to study how cocaine use affects HIV infection

MRI and ultrasound can detect fetal brain damage caused by Zika in utero

TSRI scientists developed new strategy to discover novel anti-cancer therapies

METTLER TOLEDO’s updated UV/VIS spectrophotometers can perform color measurements, automation

Chromatrap ChIP-Seq kits can deliver streamlined protocol from nanograms of starting material

Drug combination produces synergistic effect against growth of triple-negative breast cancer

Existing drugs may be able to improve therapy for chronic myeloid leukemia, mice study shows

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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