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Innate immune cells of myeloid lineage play central role in AD pathogenesis than previously thought

Many genes linked to late-onset Alzheimer's disease (AD) are expressed in myeloid cells and regulated by a single protein, according to research conducted at the Icahn School of Medicine at Mount Sinai and published June 19 in the journal Nature Neuroscience.

27 Jun 2017

Scientists resolve 3D protein structures to combat dangerous infectious diseases

An international team of scientists including the Computation Institute has determined the 3-D atomic structures of more than 1,000 proteins that are potential targets for drugs and vaccines to combat some of the world's most dangerous emerging and re-emerging infectious diseases.

22 Jun 2017

Faulty BRCA genes and their linkage to breast and ovarian cancer: Study

A new large scale study has focussed on faulty BRCA genes and their linkage to breast and ovarian cancer. The research could help doctors counsel and advise their patients in a more definitive way in terms of treatment as well as lifestyle changes that could minimize cancer risk.

20 Jun 2017

Researchers discover broad role for DNA-cutting enzyme in driving abnormal genetic rearrangements

Researchers studying a DNA-cutting enzyme with a crucial role in regulating the structure of genes have discovered a broad role for its cutting activity in driving abnormal genetic rearrangements called translocations that cause cancer, including leukemias and solid tumors.

16 Jun 2017

Penn/CHOP research helps to better understand cause of pediatric and treatment-related leukemias

Certain pediatric leukemias share a common underlying cause with treatment-related secondary leukemias.

16 Jun 2017

Early life stress encodes lifelong susceptibility to depression through alterations in brain reward region

Early life stress encodes lifelong susceptibility to stress through long-lasting transcriptional programming in a brain reward region implicated in mood and depression, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published June 15 in the journal Science.

15 Jun 2017

Researchers bioengineer human liver tissues that mimic natural development

An international team of researchers bioengineering human liver tissues uncovered previously unknown networks of genetic-molecular crosstalk that control the organ's developmental processes – greatly advancing efforts to generate healthy and usable human liver tissue from human pluripotent stem cells.

15 Jun 2017

UNC study uncovers crucial function of key enzyme found in virtually all organisms

UNC School of Medicine researchers have cracked a long-standing mystery about an important enzyme found in virtually all organisms other than bacteria.

13 Jun 2017

TSRI scientists solve cellular mystery that may have implications for fundamental biology

Scientists at The Scripps Research Institute have solved a cellular mystery that may have important implications for fundamental biology and diseases like ALS.

13 Jun 2017

Researchers uncover seven risk genes for insomnia

An international team of researchers has found, for the first time, seven risk genes for insomnia. With this finding the researchers have taken an important step towards the unraveling of the biological mechanisms that cause insomnia.

12 Jun 2017

Researchers who study HED identify mechanism that may be disrupted in male pattern baldness

It is almost axiomatic in medicine that the study of rare disorders informs the understanding of more common, widespread ailments.

8 Jun 2017

Tumorigenesis may be induced from neighboring tissues, study suggests

Current view is that cancer development is initiated from cells that acquire initial DNA mutations. These in turn provoke additional defects, and ultimately the affected cells begin to proliferate in an uncontrolled manner to develop primary tumors.

2 Jun 2017

New study establishes link between prenatal stress and onset of eating disorders

Stress affects the body and can trigger illness -- from psychiatric disorders to heart disease. Humans are exposed to stress at different intensities throughout life -- as children, in adolescence, and in old age. But when is the impact of stress on our systems most powerful? Many researchers maintain that the critical effect occurs prenatally, inside the womb.

1 Jun 2017

Study finds that immune factors have cardioproliferative effects

In adult mammal hearts, cardiomyoctyes do not proliferate following damage, like that caused by myocardial infarction. However, the inability to proliferate is not true for all animals, and even in mammals, cardiomyocyte proliferation is known.

30 May 2017

UNC researchers discover cascade of gene activity during journey to maturation in fruit flies

Every animal starts as a clump of cells, which over time multiply and mature into many different types of cells, tissues, and organs.

26 May 2017

Study finds two genetic variants linked to bicuspid aortic valve development

Researchers are working to determine why the aortic valve doesn't form correctly in patients with the most common congenital heart defect: bicuspid aortic valve.

25 May 2017

Researchers identify key regulator gene for formation of cardiac valves

Researchers from the University of Basel in Switzerland have identified a key regulator gene for the formation of cardiac valves - a process crucial to normal embryonic heart development. These results are published in the journal Cell Reports today.

23 May 2017

Hormetic cognitive stress from exposure to technology may reduce age-related disease

It appears inevitable that technology is increasingly taking over our lives. However, it seems that it can also help us avoid aging and age-related disease, in a way that has not been described before.

19 May 2017

Microbes can manipulate molecular machinery of host cells to influence health

All animals -- from sea sponges to modern-day humans -- evolved in a world already teeming with microbes. These single-celled microorganisms now cover practically every surface of our bodies and are as much a part of our biology as our own tissues and organs.

17 May 2017

Researchers develop simple urine-based test for rapid and accurate detection of Zika virus

There is no vaccine. No medication. And, no quick, reliable test for Zika virus … until now. Babies born with the virus often have lifelong, devastating birth defects.

15 May 2017