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Bile acid may help treat fatty liver disease and obesity

A bile acid that can turn off a receptor in the gut has prevented and reversed fatty liver disease in mice, according to an international team of researchers. The compound may help treat certain metabolic disorders, such as Type 2 diabetes and obesity, as well.

16 Dec 2015

Genes vital for age-related cognitive declines in memory identified in adult worm neurons

Researchers from Princeton University have identified genes important for age-related cognitive declines in memory in adult worm neurons, which had not been studied previously. The research, published in the journal Nature, could eventually point the way toward therapies to extend life and enhance health in aging human populations.

15 Dec 2015

CRISPR-Cas9 can help knock out genes in exotic animals

The simplicity of CRISPR-Cas9 gene editing will soon make studying the genes of any organism, from the simplest slime mold to the octopus, as easy as it now is to study the genes controlling development in standard lab animals such as nematodes, fruit flies, frogs and mice.

12 Dec 2015

Cancer drug can neutralize toxic RNA that causes myotonic dystrophy

A group of researchers has shown for the first time in cells and in a mouse model that a drug used to treat cancer can neutralize the toxic RNA that causes the prolonged muscle contractions and other symptoms of myotonic dystrophy type 1, the most common form of adult-onset muscular dystrophy.

11 Dec 2015

Gene mutations that cause congenital heart disease also lead to neurodevelopmental delays

Some of the same gene mutations that cause heart defects in children also lead to neurodevelopmental delays, including learning disabilities. A large study of congenital heart disease (CHD) reveals overlapping genetic influences during early childhood development.

9 Dec 2015

Dietary sugar may help to treat melanoma

New research from scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) suggests that a rare sugar found in seaweed, mushrooms, seeds and other foods may be able to help treat skin cancer.

9 Dec 2015

UB researchers develop a way to ramp up conversion of skin cells into dopamine neurons

For decades, the elusive holy grail in Parkinson's disease research has been finding a way to repair faulty dopamine neurons and put them back into patients, where they will start producing dopamine again. Researchers have used fetal material, which is difficult to obtain and of variable quality. Embryonic stem cells represented a tremendous innovation, but making dopamine neurons from stem cells is a long process with a low yield.

8 Dec 2015

Existing compound offers hope for slowing Huntington's disease progression

Currently, there is no treatment to halt the progression of Huntington's disease (HD), a fatal genetic disorder that slowly robs sufferers of their physical and mental abilities. Now, researchers at University of California, San Diego School of Medicine have discovered that an existing compound, previously tested for diabetes, offers hope for slowing HD and its symptoms.

8 Dec 2015

UofL researchers discover mechanism involved in skeletal muscle repair

Researchers at the University of Louisville have discovered a mechanism involved in skeletal muscle repair that may enable clinicians to boost the effectiveness of adult stem cell therapies for diseases such as muscular dystrophy.

1 Dec 2015

Research reveals MECP2 Duplication Syndrome can be reversed

The methyl CpG binding protein 2 gene (MECP2) produces a protein of the same name, the level of which is critical for normal brain function. Mutations leading to protein under-expression cause Rett Syndrome while gene duplication causing over-expression lead to MECP2 Duplication Syndrome. Both disorders are severely debilitating childhood neurological diseases.

26 Nov 2015

Researchers suggest new way to target cancer protein

For years, scientists have struggled to find a way to block a protein known to play an important role in many cancers. The protein, STAT3, acts as a transcription factor -- it performs the crucial task of helping convert DNA into the RNA instructions used to make new proteins.

19 Nov 2015

Simple microRNA sensor holds promise for prognosis, treatment of pancreatic and other cancers

A simple, ultrasensitive microRNA sensor developed and tested by researchers from the schools of science and medicine at Indiana University-Purdue University Indianapolis and the Indiana University Melvin and Bren Simon Cancer Center holds promise for the design of new diagnostic strategies and, potentially, for the prognosis and treatment of pancreatic and other cancers.

18 Nov 2015

Study reveals why colorectal cancer still returns in some patients after treatment

Cetuximab, marketed as Erbitux, is one of the key therapies for metastatic colorectal cancer. Yet the cancer still returns in some patients, shortening overall survival.

17 Nov 2015

Crucial change in single DNA base predisposes children to aggressive form of cancer

Pediatric oncology researchers have pinpointed a crucial change in a single DNA base that both predisposes children to an aggressive form of the childhood cancer neuroblastoma and makes the disease progress once tumors form.

12 Nov 2015

New findings reveal association between colorectal cancer and melanoma drug treatment

Veteran cancer reseacher Prof. Emeritus Alexander Levitzki of Hebrew University of Jerusalem says new findings show link between colorectal cancer and melanoma drug treatment knoqwn as "NT157" in two recently published studies in journal, "Ocogene."

10 Nov 2015

Genetic reduction of AMPK enzyme can prevent or delay hearing loss

A mitochondrial defect is responsible for a type of human hereditary deafness that worsens over time and can lead to profound hearing loss.

6 Nov 2015

Patients with Down syndrome face additional challenge of early-onset dementia

Individuals with Down syndrome who survive into adulthood face the additional challenge of early-onset dementia, in which toxic amyloid plaques build up in the brain. The condition is strikingly similar to Alzheimer's disease, and as new work led by researchers at the Lewis Katz School of Medicine at Temple University shows, dementia in Down syndrome involves defects in a regulatory enzyme known as γ-secretase activating protein (GSAP), which also happens to malfunction in Alzheimer's disease.

3 Nov 2015

UCSD researchers develop new computational strategy to find tumor-shrinking molecules

Patients with glioblastoma, a type of malignant brain tumor, usually survive fewer than 15 months following diagnosis. Since there are no effective treatments for the deadly disease, University of California, San Diego researchers developed a new computational strategy to search for molecules that could be developed into glioblastoma drugs. In mouse models of human glioblastoma, one molecule they found shrank the average tumor size by half.

31 Oct 2015

Researchers discover key regulator that impacts survival of lymphoma patients

An important regulator that controls the ability of tumour cells to hide from the immune system in lymphoma patients, making them unlikely to respond to standard treatment, has been discovered by scientists at the University of Oxford.

31 Oct 2015

Scientists identify new jelly-like properties of essential proteins that lead to serious diseases

Scientists at the University of Cambridge have identified a new property of essential proteins which, when it malfunctions, can cause the build up, or 'aggregation', of misshaped proteins and lead to serious diseases.

31 Oct 2015

Transcription News and Research

Bile acid may help treat fatty liver disease and obesity

Genes vital for age-related cognitive declines in memory identified in adult worm neurons

CRISPR-Cas9 can help knock out genes in exotic animals

Cancer drug can neutralize toxic RNA that causes myotonic dystrophy

Gene mutations that cause congenital heart disease also lead to neurodevelopmental delays

Dietary sugar may help to treat melanoma

UB researchers develop a way to ramp up conversion of skin cells into dopamine neurons

Existing compound offers hope for slowing Huntington's disease progression

UofL researchers discover mechanism involved in skeletal muscle repair

Research reveals MECP2 Duplication Syndrome can be reversed

Researchers suggest new way to target cancer protein

Simple microRNA sensor holds promise for prognosis, treatment of pancreatic and other cancers

Study reveals why colorectal cancer still returns in some patients after treatment

Crucial change in single DNA base predisposes children to aggressive form of cancer

New findings reveal association between colorectal cancer and melanoma drug treatment

Genetic reduction of AMPK enzyme can prevent or delay hearing loss

Patients with Down syndrome face additional challenge of early-onset dementia

UCSD researchers develop new computational strategy to find tumor-shrinking molecules

Researchers discover key regulator that impacts survival of lymphoma patients

Scientists identify new jelly-like properties of essential proteins that lead to serious diseases

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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