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FABP5 protein enhances cognitive function

Case Western Reserve researchers have discovered that a protein previously implicated in disease plays such a positive role in learning and memory that it may someday contribute to cures of cognitive impairments.

5 May 2014

Virginia Tech scientist receives grant to develop technique to detect subcellular location of protein

Virginia Tech chemical engineer Chang Lu and his colleagues have used a National Science Foundation grant to develop a technique to detect subcellular location of a protein.

26 Apr 2014

MGH investigators develop next-generation genome editing system

A next-generation genome editing system developed by Massachusetts General Hospital investigators substantially decreases the risk of producing unwanted, off-target gene mutations. In a paper receiving online publication in Nature Biotechnology, the researchers report a new CRISPR-based RNA-guided nuclease technology that uses two guide RNAs, significantly reducing the chance of cutting through DNA strands at mismatched sites.

26 Apr 2014

Researchers develop gene therapy reversing memory loss in mice with early-stage Alzheimer's

Alzheimer's disease is the first cause of dementia and affects some 400,000 people in Spain alone. However, no effective cure has yet been found. One of the reasons for this is the lack of knowledge on the cellular mechanisms which cause alterations in nerve transmissions and the loss of memory in the initial stages of the disease.

25 Apr 2014

Fibroblasts could offer alternative to heart transplants for patients with heart disease

Fibroblasts, cells long thought to be boring and irrelevant, could offer an alternative to heart transplants for patients with heart disease.

25 Apr 2014

Investigators use computer-assisted approach to identify and rank new clock genes

Over the last few decades researchers have characterized a set of clock genes that drive daily rhythms of physiology and behavior in all types of species, from flies to humans.

23 Apr 2014

Scientists uncover new way immune system may fight cancers and viral infections

Scientists have uncovered a new way the immune system may fight cancers and viral infections. The finding could aid efforts to use immune cells to treat illness.

18 Apr 2014

Researchers identify new Chinese herbal medicine that inhibits hepatitis C virus activity

Data from a late-breaking abstract presented at the International Liver CongressTM 2014 identifies a new compound, SBEL1, that has the ability to inhibit hepatitis C virus (HCV) activity in cells at several points in the virus' lifecycle.

15 Apr 2014

Tumor-suppressing protein acts as dimmer switch to dial down gene expression

A tumor-suppressing protein acts as a dimmer switch to dial down gene expression. It does this by reading a chemical message attached to another protein that's tightly intertwined with DNA, a team led by scientists at The University of Texas MD Anderson Cancer Center reported at the AACR Annual Meeting 2014.

11 Apr 2014

Einstein faculty members present recent research at AACR Annual Meeting

From uncovering the role nerve cells play in metastasis to identifying new cancer-causing genes, researchers at Albert Einstein College of Medicine of Yeshiva University made notable advances in the understanding and potential treatment of cancer during the past year.

29 Mar 2014

Scientists discover why cerebellar granule cell neurons in A-T patients fail to repair DNA damage

A team of scientists, led by Stuart Lipton, M.D., Ph.D., professor and director of the Neuroscience and Aging Research Center at Sanford-Burnham Medical Research Institute, recently discovered why cerebellar granule cell neurons in patients suffering from ataxia-telangiectasia (A-T) were unable to repair DNA damage and thus died.

26 Mar 2014

Study shows how transcription factor p73 promotes process of producing fertile sperm

The process of producing high-quality, fertile sperm requires many steps. A study in The Journal of Cell Biology shows how the transcription factor p73 promotes this process by regulating the adhesions between developing sperm and their support cells.

25 Mar 2014

Researchers identify steps by which cell removes RNA from cytoplasm

RNA encodes the proteins that play a key role in cellular reproduction, but the manner in which cells regulate its removal once these proteins are synthesized remains a mystery. One piece of this mystery has been solved as researchers at the University of North Carolina at Chapel Hill who have identified the steps by which a cell removes RNA from the cytoplasm.

21 Mar 2014

Proteins that regulate energy metabolism are essential for stem cell formation

Proteins that regulate energy metabolism are essential for stem cell formation, University of Washington researchers find.

21 Mar 2014

Novel feedback provides mechanistic link between chronic inflammation and carcinogenesis

Researchers of Ludwig-Maximilians-Universitaet (LMU) in Munich have discovered a novel feedback mechanism that provides a mechanistic link between chronic inflammation and carcinogenesis.

20 Mar 2014

Restless legs syndrome alters expression of critical gene during fetal development of brain

In a study published online in Genome Research, researchers of the Helmholtz Zentrum München und the Technische Universität München have demonstrated that a common genetic variant associated with Restless Legs Syndrome (RLS) alters the expression of a critical gene during fetal development of the brain.

19 Mar 2014

Transcription News and Research

FABP5 protein enhances cognitive function

Virginia Tech scientist receives grant to develop technique to detect subcellular location of protein

MGH investigators develop next-generation genome editing system

Researchers develop gene therapy reversing memory loss in mice with early-stage Alzheimer's

Fibroblasts could offer alternative to heart transplants for patients with heart disease

Investigators use computer-assisted approach to identify and rank new clock genes

Scientists uncover new way immune system may fight cancers and viral infections

Researchers identify new Chinese herbal medicine that inhibits hepatitis C virus activity

Tumor-suppressing protein acts as dimmer switch to dial down gene expression

Einstein faculty members present recent research at AACR Annual Meeting

Scientists discover why cerebellar granule cell neurons in A-T patients fail to repair DNA damage

Study shows how transcription factor p73 promotes process of producing fertile sperm

Researchers identify steps by which cell removes RNA from cytoplasm

Proteins that regulate energy metabolism are essential for stem cell formation

Novel feedback provides mechanistic link between chronic inflammation and carcinogenesis

Restless legs syndrome alters expression of critical gene during fetal development of brain

ChromaTrap™ Chromatin Immunoprecipitation technology receives positive commentary in published paper

TAF proteins may serve as potential targets to fight ovarian cancer

Researchers use computer-aided design tool to create genetic languages of biological systems

Aged mice lacking antioxidant protein Nrf2 show poor stem cell regeneration

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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