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TAZ gene represents potential target for drug therapies to treat aggressive types of breast cancer

Significance: Understanding more about how the different types of cells in breast tissue develop improves our knowledge of breast cancer. TAZ represents a potential new target for drug therapies to treat aggressive types of breast cancer.

7 Mar 2014

Research reveals 2 key mechanisms of oxidative stress regulation

Regulation of oxidative stress is critical to cell survival. New preclinical research from Roswell Park Cancer Institute (RPCI) has revealed two key mechanisms by which oxidative stress is regulated in normal and cancerous cells.

7 Mar 2014

Scientists reveal how a genetic code variation results in devastating brain diseases

New findings reveal how a mutation, a change in the genetic code that causes neurodegeneration, alters the shape of DNA, making cells more vulnerable to stress and more likely to die.

6 Mar 2014

Max Planck scientists identify new mechanisms in cellular stress response

When an organism is exposed to life-threatening conditions, it sounds the alarm and a cellular emergency program, the heat shock response, is initiated.

3 Mar 2014

Protein that controls Drosophila nervous system may play role in reversing brain injuries in human

A protein that controls the metamorphosis of the common fruit fly could someday play a role in reversing brain injuries, said Duke University researchers.

28 Feb 2014

Study identifies promising target for new drugs to treat lethal form of brain cancer

A molecule in cells that shuts down the expression of genes might be a promising target for new drugs designed to treat the most frequent and lethal form of brain cancer, according to a new study by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

27 Feb 2014

H4 receptor activation plays part in NSCLC progression

Histamine H4 receptor activation decreases epithelial-to-mesenchymal transmission in non-small-cell lung cancer, Chinese research shows.

27 Feb 2014

Researchers create new nerve cells in brains and spinal cords of living mammals

UT Southwestern Medical Center researchers created new nerve cells in the brains and spinal cords of living mammals without the need for stem cell transplants to replenish lost cells.

27 Feb 2014

Novel SCLC tumour suppressor gene discovered

Inactivation of the MYC-associated factor X gene, MAX, may play a significant role in the development of small-cell lung cancer, scientists believe.

26 Feb 2014

Researchers develop novel technique for detecting ALK rearrangements in non-small cell lung cancers

Researchers have developed a novel technique for detecting ALK rearrangements in non-small cell lung cancers (NSCLCs) that is more sensitive and easier to perform than currently available techniques.

25 Feb 2014

CardioCell announces new clinical trials using allogeneic stem-cell therapy to treat subjects with AMI

CardioCell LLC announces two new clinical trials using its allogeneic stem-cell therapy to treat subjects with acute myocardial infarction (AMI), a problem facing more than 1.26 million Americans annually.

20 Feb 2014

Small non-coding RNAs can help predict individuals with breast cancer

Small non-coding RNAs can be used to predict if individuals have breast cancer conclude researchers who contribute to The Cancer Genome Atlas project. The results, which are published in EMBO reports, indicate that differences in the levels of specific types of non-coding RNAs can be used to distinguish between cancerous and non-cancerous tissues. These RNAs can also be used to classify cancer patients into subgroups of individuals that have different survival outcomes.

18 Feb 2014

Old FDA-approved drugs may hold promise for treatment of rare, drug-resistant cancer

University of Pittsburgh Cancer Institute (UPCI) scientists have shown that old drugs might be able to do new tricks.

14 Feb 2014

Elusive progenitor cells that give rise to ILCs identified in fetal liver and bone marrow of mice

The elusive progenitor cells that give rise to innate lymphoid cells-a recently discovered group of infection-fighting white blood cells-have been identified in fetal liver and adult bone marrow of mice, researchers from the University of Chicago report early online in the journal Nature.

14 Feb 2014

EMT program in human cells may provide an effective approach for treating triple-negative breast cancer

A new study led by University of Kentucky Markey Cancer Center researcher Peter Zhou shows that targeting Twist, a nuclear protein that is an accelerant of the epithelial-mesenchymal transition (EMT) program in human cells, may provide an effective approach for treating triple-negative breast cancer.

12 Feb 2014

Study points to molecular pathway to treat recurring, deadly malignancies

Analyzing the genomes of twin 3-year-old sisters – one healthy and one with aggressive leukemia – led an international team of researchers to identify a novel molecular target that could become a way to treat recurring and deadly malignancies.

9 Feb 2014

Study: Genetic mutations in titin gene can cause skeletal muscle disease

A University of Arizona doctoral candidate has shown for the first time that genetic mutations in the titin gene can cause skeletal muscle myopathy, a disease in which muscle fibers do not function properly, resulting in muscle weakness.

29 Jan 2014

Scientists provide new insights into molecular regulation of stem cell differentiation

The findings of the scientists of the Institute of Diabetes and Regeneration Research (IDR) at Helmholtz Zentrum München (HMGU) provide new insights into the molecular regulation of stem cell differentiation.

25 Jan 2014

Blood methylome offers clues to schizophrenia

Researchers show that a methylome-wide association study of the blood can provide a glimpse of past environmental insults that may contribute to the development of schizophrenia.

22 Jan 2014

Scientists identify specific enzyme essential for brain development

Scientists from the Max F. Perutz Laboratories (MFPL) of the University of Vienna and the Medical University of Vienna have identified a specific enzyme, histone deacetylase 2 (HDAC2), as essential for brain development. The findings published in Development are important to advance the development of new drugs to treat neurological diseases.

22 Jan 2014

Transcription News and Research

TAZ gene represents potential target for drug therapies to treat aggressive types of breast cancer

Research reveals 2 key mechanisms of oxidative stress regulation

Scientists reveal how a genetic code variation results in devastating brain diseases

Max Planck scientists identify new mechanisms in cellular stress response

Protein that controls Drosophila nervous system may play role in reversing brain injuries in human

Study identifies promising target for new drugs to treat lethal form of brain cancer

H4 receptor activation plays part in NSCLC progression

Researchers create new nerve cells in brains and spinal cords of living mammals

Novel SCLC tumour suppressor gene discovered

Researchers develop novel technique for detecting ALK rearrangements in non-small cell lung cancers

CardioCell announces new clinical trials using allogeneic stem-cell therapy to treat subjects with AMI

Small non-coding RNAs can help predict individuals with breast cancer

Old FDA-approved drugs may hold promise for treatment of rare, drug-resistant cancer

Elusive progenitor cells that give rise to ILCs identified in fetal liver and bone marrow of mice

EMT program in human cells may provide an effective approach for treating triple-negative breast cancer

Study points to molecular pathway to treat recurring, deadly malignancies

Study: Genetic mutations in titin gene can cause skeletal muscle disease

Scientists provide new insights into molecular regulation of stem cell differentiation

Blood methylome offers clues to schizophrenia

Scientists identify specific enzyme essential for brain development

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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