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Researchers identify alterations in proteins responsible for RNA splicing in Alzheimer's

Researchers at Emory University School of Medicine's Alzheimer's Disease Research Center have identified a previously unrecognized type of pathology in the brains of patients with Alzheimer's disease.

11 Sep 2013

Researchers discover inherited gene mutation linked to childhood leukemia

Researchers have discovered the first inherited gene mutation linked exclusively to acute lymphoblastic leukemia occurring in multiple relatives in individual families. The discovery of the PAX5 gene mutation was led by St. Jude Children's Research Hospital and others. The work appears in the current advance online edition of the scientific journal Nature Genetics.

11 Sep 2013

Interferon-alpha 2b and ribavirin treatment may be effective for MERS-CoV infection

Treatment with two common drugs reduced viral replication and lung damage when given to monkeys infected with the virus that causes Middle East Respiratory Syndrome. The condition is deadly pneumonia that has killed more than 100 people, primarily in the Middle East.

10 Sep 2013

Chemists Find New Way To Put The Brakes On Cancer

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10 Sep 2013

Scientists identify RNA regulator that plays critical role in proper functioning of hESCs

Scientists at A*STAR's Genome Institute of Singapore, in collaboration with their counterparts from Canada, Hong Kong and US, have discovered a protein mediator SON plays a critical role in the health and proper functioning of human embryonic stem cells. This finding was reported on 8th September 2013 in the advanced online issue of the prestigious science journal Nature Cell Biology.

10 Sep 2013

Researchers identify genetic link specific to risk of childhood leukemia

For the first time, a genetic link specific to risk of childhood leukemia has been identified, according to a team of researchers from Memorial Sloan-Kettering Cancer Center, St. Jude Children's Research Hospital, University of Washington, and other institutions. The discovery was reported online today in the journal Nature Genetics.

10 Sep 2013

Researchers investigate importance of STAT1 phosphorylation in NK cells

Since its discovery in the early 1990s, the protein STAT1 (Signal Transducer and Activator of Transcription 1) has been found to be central in passing signals across immune cells, ensuring that our bodies react quickly and appropriately to threats from viruses or other pathogens.

7 Sep 2013

Assay aids ALK fusion detection in lung adenonocarcinoma

A fully automated immunochemistry assay is highly sensitive and specific for detecting anaplastic lymphoma kinase fusion in primary lung adenocarcinomas, Chinese researchers report.

6 Sep 2013

Blind mole-rats live underground in low-oxygen environments, are long-lived and resistant to cancer

Like naked mole-rats (Heterocephalus gaber), blind mole-rats (of the genus Spalax) live underground in low-oxygen environments, are long-lived and resistant to cancer. A new study demonstrates just how cancer-resistant Spalax are, and suggests that the adaptations that help these rodents survive in low-oxygen environments also play a role in their longevity and cancer resistance.

4 Sep 2013

ddPCR technology can be used to reproducibly quantify microRNA in plasma

A study published online in Nature Methods today demonstrated that Droplet Digital PCR (ddPCR-) technology can be used to precisely and reproducibly quantify microRNA (miRNA) in plasma and serum across different days, paving the way for further development of miRNA and other nucleic acids as circulating biomarkers.

2 Sep 2013

Schizophrenia genetics come into focus

A study in Nature Genetics illustrates the large impact of genetic variation on risk for schizophrenia.

30 Aug 2013

Study provides first genomic characterization of remission in juvenile rheumatoid arthritis patients

More children with juvenile rheumatoid arthritis are experiencing remission of their symptoms, thanks to new biological therapies, but the remission is not well-understood. A new study published today in Arthritis Research & Therapy provides the first genomic characterization of remission in juvenile rheumatoid arthritis patients.

30 Aug 2013

Protein activated by inflammation converts glioblastoma multiforme cells to most aggressive form

A prominent protein activated by inflammation is the key instigator that converts glioblastoma multiforme cells to their most aggressive, untreatable form and promotes resistance to radiation therapy, an international team lead by researchers at The University of Texas MD Anderson Cancer Center reported online today in the journal Cancer Cell.

30 Aug 2013

Problems with key enzymes potentially lead to autism spectrum disorder

Problems with a key group of enzymes called topoisomerases can have profound effects on the genetic machinery behind brain development and potentially lead to autism spectrum disorder, according to research announced today in the journal Nature.

29 Aug 2013

Tumor Suppressor May Actually Drive Cancer Development

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28 Aug 2013

Study paves way for understanding the crucial role of lncRNA in human neurons

Scientists at A*STAR's Genome Institute of Singapore have discovered an unusual gene that controls the generation of neurons. This important finding, which is crucial in understanding serious diseases of the brain such as Alzheimer's disease, was reported in the 8th August 2013 issue of the prestigious scientific journal, Molecular Cell.

28 Aug 2013

ASO may correct striatal transcriptional abnormalities and improve behavioral problems in HD mice

Findings from postmortem studies of the brains of Huntington's Disease (HD) patients suggest that transcriptional dysregulation may be an early step in the pathogenesis of HD before symptoms appear. Other studies report transcriptional alterations in the brains of some mouse models of HD.

27 Aug 2013

Transcription News and Research

Researchers identify alterations in proteins responsible for RNA splicing in Alzheimer's

Researchers discover inherited gene mutation linked to childhood leukemia

Interferon-alpha 2b and ribavirin treatment may be effective for MERS-CoV infection

Chemists Find New Way To Put The Brakes On Cancer

Scientists identify RNA regulator that plays critical role in proper functioning of hESCs

Researchers identify genetic link specific to risk of childhood leukemia

Researchers investigate importance of STAT1 phosphorylation in NK cells

Assay aids ALK fusion detection in lung adenonocarcinoma

Blind mole-rats live underground in low-oxygen environments, are long-lived and resistant to cancer

ddPCR technology can be used to reproducibly quantify microRNA in plasma

Schizophrenia genetics come into focus

Study provides first genomic characterization of remission in juvenile rheumatoid arthritis patients

Protein activated by inflammation converts glioblastoma multiforme cells to most aggressive form

Problems with key enzymes potentially lead to autism spectrum disorder

Tumor Suppressor May Actually Drive Cancer Development

Study paves way for understanding the crucial role of lncRNA in human neurons

ASO may correct striatal transcriptional abnormalities and improve behavioral problems in HD mice

TSRI scientists find way to use new DNA-editing technology for DNA sequencing

UAB study points to protein pathway that could lead to new treatments for diabetes

Scientists Shed New Light On Malignant Pancreatic Cancer

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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