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Study shows disrupted micronuclei may prove to be a valuable tool for detecting cancer

Scientists studying cancer development have known about micronuclei for some time. These erratic, small extra nuclei, which contain fragments or whole chromosomes that were not incorporated into daughter cells after cell division, are associated with specific forms of cancer and are predictive of poorer prognosis.

10 Jul 2013

Disrupted micronuclei might play more active role in carcinogenesis, new study finds

9 Jul 2013

Drugs used to control BP associated with lower risk of heart failure in diabetic patients

Two drugs, telmisartan and valsartan, which are used to reduce blood pressure in people with diabetes, are associated with a lower risk of hospitalization for heart attack, stroke or heart failure, according to a study published in CMAJ (Canadian Medical Association Journal).

9 Jul 2013

Collaborative research yields a wiring map on how TB responds to changes in environment

Despite decades of research on the bacterium that causes tuberculosis (TB), scientists have not had a comprehensive understanding of how the bacterium is wired to adapt to changing conditions in the host.

5 Jul 2013

Researchers identify role of Nanog gene in embryonic stem cell differentiation

Whitehead Institute researchers have determined that the transcription factor Nanog, which plays a critical role in the self-renewal of embryonic stem cells, is expressed in a manner similar to other pluripotency markers.

4 Jul 2013

Human gene expression mechanism opens new therapeutic strategies against neurological disease

In a study that could change the way scientists view the process of protein production in humans, University of Chicago researchers have found a single gene that encodes two separate proteins from the same sequence of messenger RNA.

4 Jul 2013

Discovery sheds new light on aggressiveness of certain breast cancers

In a discovery that sheds new light on the aggressiveness of certain breast cancers, Whitehead Institute researchers have identified a transcription factor, known as ZEB1, that is capable of converting non-aggressive basal-type cancer cells into highly malignant, tumor-forming cancer stem cells (CSCs). Intriguingly, luminal breast cancer cells, which are associated with a much better clinical prognosis, carry this gene in a state in which it seems to be permanently shut down.

4 Jul 2013

Scientists identify molecular signals that spur the formation of arteries

The ability to form blood vessels is one of evolution's crowning achievements, and something that separates vertebrates (animals with a backbone) from the rest of the animal kingdom.

4 Jul 2013

Researchers find NRF2 signaling plays a role in growth of tumor cells by altering metabolic pathways

Cancer cells have alteration in metabolic pathways as a result of oncogenes that promote tumor growth. NRF2 (nuclear factor erythroid-derived 2-related factor 2) works as a "master gene" that turns on stress response by increasing numerous antioxidants and pollutant-detoxifying genes to protect the lungs from variety of air pollutants such as diesel exhaust and cigarette smoke.

3 Jul 2013

Researchers discover an important mechanism that regulates proteasome activity

Dysfunction of the ubiquitin-proteasome system (UPS) has been detected in many neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, and certain types of cancer. Such dysfunction is also believed to be related to some degenerative muscle diseases. Researchers at the University of Helsinki, Finland, have now discovered an important mechanism that regulates proteasome activity.

1 Jul 2013

Scientists compare DNA sequences, genes of domestic and wild tomatoes

You say tomato, I say comparative transcriptomics. Researchers in the U.S., Europe and Japan have produced the first comparison of both the DNA sequences and which genes are active, or being transcribed, between the domestic tomato and its wild cousins.

27 Jun 2013

UC professor receives Biemann Medal from ASMS for significant achievement in mass spectrometry

Yinsheng Wang, a professor of chemistry at the University of California, Riverside, has received the Biemann Medal, awarded by the American Society for Mass Spectrometry (ASMS) to an individual early in his or her career in recognition of significant achievement in basic or applied mass spectrometry.

26 Jun 2013

Prader-Willi syndrome results in dysregulation of circadian and metabolic genes

Researchers with the UC Davis MIND Institute and Agilent Laboratories have found that Prader-Willi syndrome - a genetic disorder best known for causing an insatiable appetite that can lead to morbid obesity - is associated with the loss of non-coding RNAs, resulting in the dysregulation of circadian and metabolic genes, accelerated energy expenditure and metabolic differences during sleep.

26 Jun 2013

Bioapplications of nanoparticles: an interview with Dr Catherine Berry, University of Glasgow

These particles are all classed as inorganic particles, which can all be utilised in biomedical applications. They differ in terms of their inherent material and size dependent physiochemical properties, for example, their optical and magnetic properties.

18 Jun 2013

Targeting SALL4 protein with druglike molecules could halt tumor growth, say researchers

Harvard Stem Cell Institute researchers have identified in the most aggressive forms of cancer a gene known to regulate embryonic stem cell self-renewal, beginning a creative search for a drug that can block its activity.

18 Jun 2013

Mount Sinai researchers produce cells that resemble hematopoietic stem cells

By transferring four genes into mouse fibroblast cells, researchers at the Icahn School of Medicine at Mount Sinai have produced cells that resemble hematopoietic stem cells, which produce millions of new blood cells in the human body every day.

14 Jun 2013

Tumor suppressor p53 inactivation and restoration: an interview with Dr. Xin Lu, Ludwig Institute for Cancer Research

Before we talk about p53, it is important to understand why cancer cells are a problem for the body. Cancer cells multiply recklessly, refuse to die and blithely metastasize to set up shop in places where they don’t belong.

12 Jun 2013

Researchers find master regulator of EMT and metastasis

The predominant cause of death in cancer patients is metastasis, the formation of secondary tumors in other organs like the brain, liver, and lungs. Cancer cells detach from the original primary tumor and reach a single cell or group of cells in another organ. The cells of the body normally remain in place through adhering to an extracellular substance. However, cancer cells learn how to release themselves from these bonds and invade surrounding tissues, blood, and the lymphatic system.

11 Jun 2013

Researchers discover potential target for cancer-fighting drugs

As tumors grow, their centers are squeezed of oxygen. And so tumors must flip specific genetic switches to survive in these hypoxic environments.

10 Jun 2013

Researchers find new way to repair genetic defects in the skin cells of epidermolysis bullosa patients

A research team led by pediatric blood and marrow transplantation experts Mark Osborn, Ph.D. and Jakub Tolar, M.D., Ph.D. from the Masonic Cancer Center, University of Minnesota, have discovered a remarkable new way to repair genetic defects in the skin cells of patients with the skin disease epidermolysis bullosa.

10 Jun 2013

Transcription News and Research

Study shows disrupted micronuclei may prove to be a valuable tool for detecting cancer

Disrupted micronuclei might play more active role in carcinogenesis, new study finds

Drugs used to control BP associated with lower risk of heart failure in diabetic patients

Collaborative research yields a wiring map on how TB responds to changes in environment

Researchers identify role of Nanog gene in embryonic stem cell differentiation

Human gene expression mechanism opens new therapeutic strategies against neurological disease

Discovery sheds new light on aggressiveness of certain breast cancers

Scientists identify molecular signals that spur the formation of arteries

Researchers find NRF2 signaling plays a role in growth of tumor cells by altering metabolic pathways

Researchers discover an important mechanism that regulates proteasome activity

Scientists compare DNA sequences, genes of domestic and wild tomatoes

UC professor receives Biemann Medal from ASMS for significant achievement in mass spectrometry

Prader-Willi syndrome results in dysregulation of circadian and metabolic genes

Bioapplications of nanoparticles: an interview with Dr Catherine Berry, University of Glasgow

Targeting SALL4 protein with druglike molecules could halt tumor growth, say researchers

Mount Sinai researchers produce cells that resemble hematopoietic stem cells

Tumor suppressor p53 inactivation and restoration: an interview with Dr. Xin Lu, Ludwig Institute for Cancer Research

Researchers find master regulator of EMT and metastasis

Researchers discover potential target for cancer-fighting drugs

Researchers find new way to repair genetic defects in the skin cells of epidermolysis bullosa patients

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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