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Potential genetic cause of congenital defect colonic atresia

In a finding that helps resolve a long-standing question in developmental biology, Klaus H. Kaestner, PhD, Professor of Genetics, and colleagues report in the journal Developmental Cell this week about how the mammalian gut forms. Mice were genetically engineered to lack the protein Cdx2 in the cells that normally go on to form the stomach and intestine.

22 Apr 2009

New insights into transcription factors in human cells

Bioinformatics researchers from UC San Diego just moved closer to unlocking the mystery of how human cells switch from "proliferation mode" to "specialization mode."

20 Apr 2009

Statins may be useful in patients with tamoxifen-resistant breast cancer

Breast cancer cells in the laboratory that don't respond to tamoxifen may be producing high amounts of cholesterol in order to provide a kind of shield against the drug, say researchers at Georgetown University Medical Center (GUMC).

20 Apr 2009

Thymoquinone inhibits the development of pancreatic cancer

An herb recently found to kill pancreatic cancer cells also appears to inhibit development of pancreatic cancer as a result of its anti-inflammatory properties, according to researchers from the Kimmel Cancer Center at Jefferson.

20 Apr 2009

Mammalian alpha-fetoprotein affects the development of rat colons

Mammalian alpha-fetoprotein (AFP) is a single-chain glycoprotein and altered serum AFP levels have been observed concurrent with aberrant growth manifestations in some congenital defects and cancer.

20 Apr 2009

A potential therapeutic target for gastric cancer

Gastric cancer (GC) is the fourth most common malignancy and the second most frequent cause of cancer-related death in the world.

20 Apr 2009

Secret to night vision in nocturnal animals revealed

Researchers have discovered an important element for making night vision possible in nocturnal mammals: the DNA within the photoreceptor rod cells responsible for low light vision is packaged in a very unconventional way, according to a report in the April 17th issue of Cell , a Cell Press publication.

16 Apr 2009

SIRT1 takes down tumors

Yuan et al. have identified another anti-cancer effect of the "longevity" protein SIRT1.

13 Apr 2009

microRNAs manipulate cells to one day create safe embryonic-like stem cells

A team of UCSF researchers has for the first time used tiny molecules called microRNAs to help turn adult mouse cells back to their embryonic state.

12 Apr 2009

Discovery of key decision-point at which cells with broken DNA repair themselves or die

When cells undergo potentially catastrophic damage, for example as a result of exposure to ionizing radiation, they must make a decision: either to fix the damage or program themselves for death, a process called apoptosis.

12 Apr 2009

$New target for treatment of hormone refractory prostate cancer$

New target for treatment of hormone refractory prostate cancer

A new study identifies a protein that modifies the androgen receptor (AR) and influences its ability to regulate target genes linked with the progression of prostate cancer.

6 Apr 2009

Researcher tackles deadly brain tumors

Natalie Ciaccio, a fourth-year graduate student researcher in the Department of Pharmaceutical Chemistry at the University of Kansas, is investigating what might be an ideal target for anti-cancer drug therapy, and she is focusing her work on brain tumors specifically.

6 Apr 2009