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Assessing immunization capacity of vaccine platforms with DNA origami harboring SARS-CoV-2 receptor binding domain

Researchers demonstrated that vaccine frameworks containing deoxyribonucleic acid (DNA) origami possessing SARS-CoV-2 receptor-binding domain induce strong protective immunity.

8 Aug 2022

Gene therapy approach delays disease onset in humanized mouse models of familial ALS

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the progressive loss of motor neurons in the brain and spinal cord responsible for voluntary movements and muscle control.

2 Aug 2022

The recent progress in investigating the inhibitory impact of nanosponges and antiviral delivery against SARS-CoV-2

Researchers assessed the potential of nanosponges against SARS-CoV-2.

1 Aug 2022

Study indicates that cross-reactive immunity against SARS-CoV-2 N protein was present in Africa prior to the pandemic

Researchers assessed the pre-existing cross-protective immune responses against SARS-CoV-2 nucleocapsid protein and spike protein before the COVID-19 pandemic in individuals residing in North and South America, Europe and Africa in vitro and in vivo.

1 Aug 2022

Tannins as therapeutic agents against SARS-CoV-2

Researchers reviewed tannins as therapeutic agents against SARS-CoV-2.

29 Jul 2022

Study investigates the combined effects of aging and HIV-1 Tat expression in mice

A new research paper was published in Aging ("Aging (Albany NY)" by Medline/PubMed, "Aging-US" by Web of Science) Volume 14, Issue 13, entitled, "Age-related neuroendocrine, cognitive, and behavioral co-morbidities are promoted by HIV-1 Tat expression in male mice."

29 Jul 2022

UMass Amherst scientist to study how embryonic exposure to pollutants may increase diabetes risk

A University of Massachusetts Amherst environmental health scientist has received a $2.44 million, five-year grant renewal from the National Institutes of Health to continue her research into how embryonic exposure to certain common pollutants may put people at risk for diabetes and other metabolic health conditions later in life.

22 Jul 2022

The clinical, epidemiological, and evolutionary consequences of a potential SARS-CoV-2-related bat virus spillover into humans

A team of scientists from France has recently described the epidemiological and clinical consequences of a bat sarbecovirus infection in humanized mice.

20 Jul 2022

Scientists evaluate immunostimulatory glycolipid against SARS-CoV-2 infection

A new study showed that 7DW8-5, an immunostimulatory glycolipid impeded three respiratory viral infections, including SARS-CoV-2, in vivo.

18 Jul 2022

New disease-modifying therapy for Alzheimer's disease may involve whole blood exchange

A novel, disease-modifying therapy for Alzheimer's disease may involve the whole exchange of blood, which effectively decreased the formation of amyloid plaque in the brains of mice, according to a new study from UTHealth Houston.

15 Jul 2022

Characterization of longer-term effects on behavior and brain inflammation following recovery from mild COVID-19

A recent study reported that long COVID in mice causes brain inflammation and cognitive impairment.

8 Jul 2022

The replicative ability and pathogenicity of Omicron BA.4 and BA.5 isolates in hamsters

Researchers characterized the clinical isolates of SARS-CoV-2 Omicron BA.4 and BA.5.

8 Jul 2022

Nanoparticle vaccine could protect against animal viruses including future SARS-CoV-2 variants

A recent study published in the Science journal depicted that mosaic receptor-binding domain (RBD) nanoparticles immunize from diverse sarbecovirus challenges, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), among animal models.

8 Jul 2022

Fatty foods may expand waistline and cause havoc to the brain

New research shows that fatty foods may not only be adding to your waistline but also playing havoc with your brain.

8 Jul 2022

Targeting C5a/C5aR1 signaling ameliorates COVID-19 immunopathology

A new study investigated the role of complement component 5a (C5a) and its receptor (C5a receptor type 1, C5aR1) in the pathophysiology of COVID-19.

6 Jul 2022

Comprehensive atlas of genetic data on zebrafish will benefit medical and life science researchers

Medical and life science researchers will benefit from the most comprehensive atlas yet of genetic data on zebrafish, newly published research suggests.

4 Jul 2022

Recombinant SARS-CoV-2 harboring double reporters for COVID-19 surveillance

In a recent article posted to the bioRxiv* preprint server, researchers at Texas Biomedical Research Institute, Georgia State University, and the University of Alabama at Birmingham developed a bireporter-expressing recombinant severe acute respiratory syndrome coronavirus 2 (rSARS-CoV-2) for tracking SARS-CoV-2 infection.

27 Jun 2022

Animal study suggests intranasal COVID vaccine delivery more efficient than intramuscular

In a recent study published in the journal PNAS, researchers demonstrated higher comparative efficacy of the intranasal (IN) route of coronavirus disease 2019 (COVID-19) vaccine administration versus intramuscular route in mice.

12 Jun 2022

Color-changing mouse model aids in better visualization of internal physiology

Biomedical and genetic engineers at Duke University and the Albert Einstein College of Medicine have developed a process to change the color of a mouse's tissue in imaging to better visualize its internal physiology.

6 Jun 2022

Researchers identify a human monoclonal antibody that could broadly neutralize several variants of SARS-CoV-2, SARS-CoV, and other coronaviruses

Researchers identified 10-40, a human monoclonal antibody with potent neutralizing activity against SARS-CoV, SARS-CoV-2, and related sarbecoviruses.

30 May 2022

Transgenic News and Research

Assessing immunization capacity of vaccine platforms with DNA origami harboring SARS-CoV-2 receptor binding domain

Gene therapy approach delays disease onset in humanized mouse models of familial ALS

The recent progress in investigating the inhibitory impact of nanosponges and antiviral delivery against SARS-CoV-2

Study indicates that cross-reactive immunity against SARS-CoV-2 N protein was present in Africa prior to the pandemic

Tannins as therapeutic agents against SARS-CoV-2

Study investigates the combined effects of aging and HIV-1 Tat expression in mice

UMass Amherst scientist to study how embryonic exposure to pollutants may increase diabetes risk

The clinical, epidemiological, and evolutionary consequences of a potential SARS-CoV-2-related bat virus spillover into humans

Scientists evaluate immunostimulatory glycolipid against SARS-CoV-2 infection

New disease-modifying therapy for Alzheimer's disease may involve whole blood exchange

Characterization of longer-term effects on behavior and brain inflammation following recovery from mild COVID-19

The replicative ability and pathogenicity of Omicron BA.4 and BA.5 isolates in hamsters

Nanoparticle vaccine could protect against animal viruses including future SARS-CoV-2 variants

Fatty foods may expand waistline and cause havoc to the brain

Targeting C5a/C5aR1 signaling ameliorates COVID-19 immunopathology

Comprehensive atlas of genetic data on zebrafish will benefit medical and life science researchers

Recombinant SARS-CoV-2 harboring double reporters for COVID-19 surveillance

Animal study suggests intranasal COVID vaccine delivery more efficient than intramuscular

Color-changing mouse model aids in better visualization of internal physiology

Researchers identify a human monoclonal antibody that could broadly neutralize several variants of SARS-CoV-2, SARS-CoV, and other coronaviruses

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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