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Synthetic gene reveals potential therapeutic target for rare, inherited disease

DNA Repair is essential for a healthy organism. In every day of our lives, tens of thousands of damages occur in the genetic material of our cells. Hence, it is not surprising that a broad variety of repair mechanisms developed in the course of evolution that enables cells to quickly react and patch up the affected DNA strands.

11 Jun 2018

Alnylam announces new positive results from Phase 1/2 study of lumasiran in patients with PH1

Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced today new positive results from its Phase 1/2 study with lumasiran, an investigational RNAi therapeutic targeting glycolate oxidase for the treatment of Primary Hyperoxaluria Type 1.

8 Jun 2018

MicroRNAs may hold key to predict how someone is affected by sleep loss

The key to predicting how someone is affected by sleep loss may be found in microRNAs, according to a new study from researchers at the Perelman School of Medicine at the University of Pennsylvania.

4 Jun 2018

MD Anderson and Amgen collaborate to accelerate early-stage oncology therapies

The University of Texas MD Anderson Cancer Center and Amgen today announced two multi-year collaboration agreements aimed at accelerating development of a variety of Amgen's early-stage oncology therapies for patients with leukemia, myelodysplastic syndromes, multiple myeloma, small-cell lung cancer, and other non-lung cancers with small-cell histologies.

1 Jun 2018

Preventing Campylobacter infections from chicken eggs

Eggs are a popular food. In fact, Germans consumed almost 20 billion of them in 2016, which equates to a per capita consumption of 235 eggs.

31 May 2018

Genomic medicine may redefine cardiovascular care in future, shows study

A new scientific statement from the American Heart Association summarizes the state-of-the-science of genomic medicine -- the study of the health effects of the molecular interactions of a person's unique genes -- for studying cardiovascular traits and disorders and for therapeutic screening.

29 May 2018

Genomic medicine may one day revolutionize cardiovascular care

The American Heart Association has summarized the state-of-the science in the field of genomic medicine for studying cardiovascular traits and disorders, therapeutic screening.

29 May 2018

Study identifies new mechanism involved in development of Lou Gehrig's disease

A new Tel Aviv University study identifies a previously unknown mechanism involved in the development of Lou Gehrig's disease, or amyotrophic lateral sclerosis.

23 May 2018

Scientists decipher workings of little-understood bacterial riboswitch

In a discovery that points to potential new antibiotic medicines, scientists from Rice University and the University of Michigan have deciphered the workings of a common but little-understood bacterial switch that cuts off protein production before it begins.

22 May 2018

Researchers use MR spectroscopy to investigate mechanisms behind targeted treatment for gliomas

Using a novel imaging method, a Massachusetts General Hospital research team is investigating the mechanisms behind a potential targeted treatment for a subtype of the deadly brains tumors called gliomas.

21 May 2018

Scientists identify new potential target to combat acute myeloid leukemia

AML is not a single disease. It is a group of leukemias that develop in the bone marrow from progenitors of specialized blood cells, the so-called myeloid cells. Rapidly growing and dividing, these aberrant cells crowd the bone marrow and bloodstream, which can be fatal within weeks or months if the disease is left untreated.

18 May 2018

Study provides insights into how immune cells kill bacteria with acid

The first line of immune defense against invading pathogens like bacteria are macrophages, immune cells that engulf every foreign object that crosses their way. After enclosing it in intracellular membrane vesicles, a process called phagocytosis, macrophages kill their prey with acid.

17 May 2018

Opioid overdoses are rising faster among Latinos than whites or blacks. Why?

The tall, gangly man twists a cone of paper in his hands as stories from nearly 30 years of addiction pour out: the robbery that landed him in prison at age 17; never getting his high school equivalency diploma; going through the horrors of detox, maybe 40 times, including this latest bout, which he finished two weeks ago. He’s now in a residential treatment unit for at least 30 days.

17 May 2018

FutureNeuro and GreenLight Medicines team up to develop cannabis-based treatments for epilepsies

A new partnership between FutureNeuro, the SFI Research Centre for Chronic and Rare Neurological diseases based at RCSI and GreenLight Medicines, an indigenous Irish biopharmaceutical company has been formed to develop new cannabis-based treatments for drug-resistant epilepsies, and in particular, childhood epilepsies.

17 May 2018

Cleveland Clinic researcher wins NCI grant to delve into cancer genetics and radiation effectiveness

Can the genetic makeup of their cancers predict how patients with lung cancer will respond to radiation therapy? And can this information be used to advance a genetically guided strategy for patients with these tumors? Cleveland Clinic researcher and radiation oncologist Mohamed Abazeed, M.D., Ph.D., has been awarded a $2 million grant from the National Cancer Institute (NCI) to delve into those and other related questions.

15 May 2018

Gun safety programs do not reduce likelihood of children using firearms, study finds

Children who participate in gun safety programs often ignore what they learned when encountering a real firearm, according to a Rutgers School of Nursing study.

15 May 2018

Study uncovers promising new line of attack against aggressive prostate cancer

UC San Francisco researchers have discovered a promising new line of attack against lethal, treatment-resistant prostate cancer. Analysis of hundreds of human prostate tumors revealed that the most aggressive cancers depend on a built-in cellular stress response to put a brake on their own hot-wired physiology.

14 May 2018

Increasingly failing communication between cells' organelles is main cause of aging, shows study

A basic discovery of how the cellular functions are connected to control aging is presented in the journal Cell Metabolism.

11 May 2018

Researchers develop artificial intelligence method to help cancer patients worldwide

Before performing radiation therapy, radiation oncologists first carefully review medical images of a patient to identify the gross tumor volume -- the observable portion of the disease. They then design patient-specific clinical target volumes that include surrounding tissues, since these regions can hide cancerous cells and provide pathways for metastasis.

10 May 2018

Broadridge Financial Solutions acquires Ireland-based company, FundAssist

Broadridge Financial Solutions, Inc., a global fintech leader, has completed the acquisition of FundAssist Limited, a regulatory, marketing and sales solutions service provider to the global investments industry.

9 May 2018