Transplant News and Research

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Differential effects of HOXB4 on nonhuman primate short and long-term repopulating cells

Transplantation of hematopoietic stem cells (HSCs, the cells that can give rise to all blood and most immune cell types) can save patients whose own hematopoietic system is defective or has been destroyed (often through radiation or chemotherapy of cancer).

3 May 2006

Progressive histological damage in liver allografts following pediatric liver transplantation

A new study on the long-term outcome of children undergoing liver transplants found that chronic hepatitis (CH) was common and that it was not detectible using standard blood tests.

3 May 2006

Outcome of patients with hepatitis B and HIV infections referred for liver transplantation

A new study on HIV patients who also had Hepatitis B virus (HBV) found that better outcomes are possible if they are referred early for transplant and treated with a combination of drugs for HBV. It is essential to monitor the HBV status of these patients, however, in order to control the emergence of drug-resistant HBV infection.

3 May 2006

Kidney patients warned away from potassium

Many kidney failure patients are increasing their chance of nerve damage in their legs and feet by simply having too much potassium in their diet, according to research carried out by the University of New South Wales (UNSW), the Prince of Wales Medical Research Institute (POWMRI) and the Prince of Wales Hospital.

2 May 2006

Sperm-producing stem cells found in testicles could be extracted, grown in the lab, and frozen for future use

Men may cringe at the idea, but sperm-producing stem cells found in testicles could be extracted, grown in the lab, and frozen for future use.

2 May 2006

Oh what a feeling!

Just five months after the pioneering operation Isabelle Dinoire, the world's first partial face transplant says she now has complete feeling in the new tissue on her face.

1 May 2006

Tumour specific drugs may render therapies based on a tumor's anatomical location obsolete

The results of a new study at Washington University School of Medicine in St. Louis could eventually have oncologists removing their specialties from their shingles by making therapy based on a tumor's anatomical location obsolete.

28 Apr 2006

Chinese surgeons carry out world's second face transplant

According to the Chinese state media a 30-year-old man has been given the country's first face transplant by Chinese doctors, the second operation of its kind in the world.

17 Apr 2006

Telithromycin antibiotic may help reduce some symptoms of a bad asthma attack

The researchers however believe the positive effects of the drug may be as a result of its impact on two bacteria - Chlamydophila pneumoniae and Mycoplasma pneumoniae - found present in 61% of patients in the study.

13 Apr 2006

First evidence that circulating endothelial microparticles lead to heart valve disease

Under normal physiological conditions, low levels of microparticles are continually being shed into the blood from the endothelium - the cells that line the inside of blood vessels and some organs -and appear to cause no problems.

13 Apr 2006

New insights into how anti-rejection drug daclizumab (Zenapax) helps MS patients

A research team led by the University of Cincinnati's Bibiana Bielekova, MD, report new insights into the role of the MS drug daclizumab (Zenapax) in the Proceedings of the National Academy of Sciences.

11 Apr 2006

Single dose of stem cells produce robust behavioral recovery in animal models for stroke, cerebral palsy

A single dose of adult donor stem cells given to animals that have neurological damage similar to that experienced by adults with a stroke or newborns with cerebral palsy can significantly enhance recovery from these types of injuries, researchers say.

11 Apr 2006

Researchers identify critical human cell surface molecule involved in infection by Kaposi's sarcoma herpesvirus

Researchers at the National Institute of Allergy and Infectious Disease (NIAID) have identified a critical human cell surface molecule involved in infection by Kaposi's sarcoma herpesvirus (KSHV), the virus that causes Kaposi's sarcoma and certain forms of lymphoma.

11 Apr 2006

First artificial heart implant on the East Coast

A cardiac surgery team at Virginia Commonwealth University's Pauley Heart Center has performed the first artificial heart implant on the East Coast. The CardioWest temporary Total Artificial Heart, or TAH-t, is the only total artificial heart approved by the U.S. Food and Drug Administration.

6 Apr 2006

Trends over a decade of pediatric liver transplantation in the U.S.

A new study on children undergoing liver transplants found that although innovative transplant techniques have been developed in recent years, the waitlist times for pediatric transplant candidates have increased compared to the early 1990s.

6 Apr 2006

ICG value accurately predicts outcomes in adult living-donor liver transplantation

A new study on identifying which patients were likely to have poor outcomes following a living-donor liver transplant (LDLT) found that measuring how a certain non-toxic dye was eliminated by the liver shortly after surgery was an accurate indicator of liver function, and therefore a reliable indicator of the outcome of the procedure.

4 Apr 2006

Novel therapy for chronic graft-versus-host disease

A study by Dana-Farber Cancer Institute researchers offers the strongest evidence yet of the effectiveness of a novel therapy for chronic graft-versus-host disease (GVHD), a potentially life-threatening complication of donor bone marrow and stem cell transplants.

28 Mar 2006

Procedure cures some diabetic mice, but not in the way previously reported

Researchers attempting to reproduce a controversial 2003 mouse experiment suggestive of a cure for type 1 diabetes have found evidence that the experimental procedure does eliminate diabetic symptoms in a small fraction of the mice exposed to it.

28 Mar 2006

Study provides a boost for efforts to reverse type-1 diabetes

Researchers have been able to confirm most but not all of the results of a high-profile study that brought new hope to diabetes patients. This study provides a boost for efforts to reverse type-1 diabetes in recently diagnosed patients but not for efforts to grow new islets from spleens.

27 Mar 2006

Novel therapy for chronic graft-versus-host disease (GVHD) using Rituximab

Dana-Farber researchers found that rituximab reduced the severity of chronic graft-versus-host disease (GVHD) in 70 percent of the study participants.

27 Mar 2006

Transplant News and Research

Differential effects of HOXB4 on nonhuman primate short and long-term repopulating cells

Progressive histological damage in liver allografts following pediatric liver transplantation

Outcome of patients with hepatitis B and HIV infections referred for liver transplantation

Kidney patients warned away from potassium

Sperm-producing stem cells found in testicles could be extracted, grown in the lab, and frozen for future use

Oh what a feeling!

Tumour specific drugs may render therapies based on a tumor's anatomical location obsolete

Chinese surgeons carry out world's second face transplant

Telithromycin antibiotic may help reduce some symptoms of a bad asthma attack

First evidence that circulating endothelial microparticles lead to heart valve disease

New insights into how anti-rejection drug daclizumab (Zenapax) helps MS patients

Single dose of stem cells produce robust behavioral recovery in animal models for stroke, cerebral palsy

Researchers identify critical human cell surface molecule involved in infection by Kaposi's sarcoma herpesvirus

First artificial heart implant on the East Coast

Trends over a decade of pediatric liver transplantation in the U.S.

ICG value accurately predicts outcomes in adult living-donor liver transplantation

Novel therapy for chronic graft-versus-host disease

Procedure cures some diabetic mice, but not in the way previously reported

Study provides a boost for efforts to reverse type-1 diabetes

Novel therapy for chronic graft-versus-host disease (GVHD) using Rituximab

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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