Trypanosomes News and Research

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Research on trypanosomes can open way for African sleeping sickness drug development

Trypanosomes are parasites responsible for many human and animal diseases, primarily in tropical climates. One disease these parasites cause, African sleeping sickness, results from the bite of infected tsetse flies, putting over 60 million Africans at risk in 36 sub-Saharan countries. The recent 1998-2001 sleeping sickness epidemics in South Sudan, Angola, Democratic Republic of Congo and Uganda killed tens of thousands of people and resulted in over a half million infected individuals.

31 Aug 2010

Researchers discover genetic explanation for non-diabetic kidney disease in African-Americans

Kidney disease is a growing public health problem, with approximately half a million individuals in the United States requiring dialysis treatments to replace the function of their failed kidneys. The problem is particularly acute among African-Americans, whose rates of kidney disease are four times higher than those of European Americans.

20 Jul 2010

New technique captures bacterial infection on film

Researchers have developed a new technique that allows them to make a movie of bacteria infecting their living host.

27 Jul 2009

Research suggests core nuclear pore elements shared by all eukaryotes

For perhaps 1.8 billion years after life first emerged on Earth, a sort of evolutionary writer's block stalled the development of organisms more complicated than single cells. Then, a burst of experimental creativity about 1.7 billion years ago brought the cell nucleus onto the scene, stashing the cell's genetic material inside a protective inner membrane and setting the stage for the evolution of more sophisticated creatures from yeast, say, to plants and human beings.

12 Jul 2009

Scientists develop tool to study a deadly parasite’s histone code

In the Japanese art of paper folding, a series of folds can make the same sheet of paper into a ballerina or baby elephant. But try unfolding the baby elephant and making it into a ballerina. It's like trying to make a neuron from a kidney cell. Epigenetics, it turns out, isn't much different from this old Japanese art: Each fold, or epigenetic crease, both limits and permits further potential folds in a way that mirrors how epigenetic changes seal a cell's fate.

13 May 2009

African sleeping sickness parasite breaks its own DNA to avoid detection

The parasite Trypanosoma brucei, which causes African sleeping sickness, is like a thief donning a disguise.

15 Apr 2009

Scans show immune cells intercepting parasites

Researchers may have identified one of the body's earliest responses to a group of parasites that causes illness in developing nations.

10 Dec 2008

Newly identified protein called BILBO1 fatal to Trypanosoma brucei

Trypanosoma brucei is a pathogen that causes epidemics of human and animal sleeping sickness in central and Southern Africa, a disease that is fatal if untreated. A new paper published this week in the open-access journal PLoS Biology investigates the formation of a trypanosome structure called the Flagellar Pocket (FP).

6 May 2008

When tsetse flies fall for a host, they keep coming back for more

If you like a restaurant first time around, you're likely to go back, aren't you? Well the same goes, more or less, for tsetse flies, as researchers from CIRAD, CIRDES and the University of Neuchâtel have recently demonstrated.

9 Jan 2008

Enzyme synergy shown to perpetuate sleeping sickness

The pathogenesis of the parasite African trypanosome (T. brucei) has been linked to a key protein switch, detailed in a new study by researchers at the University of Iowa and the Veterans Affairs Medical Center of Iowa City, led by Dr. John Donelson.

19 Oct 2007

Cure for African sleeping sickness

Studies of the enzyme CTP synthetase in the parasite Trypanosoma brucei have brought researchers at Umeå University in Sweden closer to a cure for African sleeping sickness.

26 Apr 2007

Genomic expansion and diversification in a African sleeping sickness parasite allow it to evade host detection

A team of scientists headed by Dr. Sara Melville at the University of Cambridge has shown that the parasite known to cause African sleeping sickness has evolved an unusual chromosomal structure as a result of environmental adaptation.

3 Aug 2006

African sleeping sickness

Each year, over 300,000 people die of African sleeping sickness (trypanosomiasis). Researchers from the Flanders Interuniversity Institute for Biotechnology (VIB) connected to the Free University of Brussels are making strides in the battle against this disease.

10 Apr 2006

Sleeping sickness parasite shows how cells divide their insides

Researchers at Yale have brought to light a mechanism that regulates the way an internal organelle, the Golgi apparatus, duplicates as cells prepare to divide, according to a report in Science Express.

7 Nov 2005

Scientists sequence the genomes of three species of parasites responsible for causing diseases that kill or cripple millions

Howard Hughes Medical Institute (HHMI) scientists who participated in the project say the sequencing of the genomes of the parasitic protozoa that cause Chagas disease, African sleeping sickness, and leishmaniasis, could significantly impact world health. Some of the genes discovered may prove to be good drug and vaccine targets.

17 Jul 2005

Potatoes found to help reduce blood pressure and other diseases

UK scientists have identified bioactive plant chemicals in the most practical of staple foods, the potato. These natural chemicals have been associated with reduced blood pressure and they selectively affect a chemotherapeutic target for trypanosomes and similar diseases such as sleeping sickness.

30 Jun 2005