Tumor Associated Macrophages News and Research

RSS

Merck declares 2018 Life Science Award winners

Merck, the vibrant science and technology company, recognized three graduate students who have demonstrated innovation in life science at an awards ceremony at the company’s global headquarters in Darmstadt, Germany recently.

From Merck 20 Nov 2018

Sleep apnea can favor lung cancer growth in young individuals

A scientific study, conducted with animal models, states that sleep apnea can favor lung cancer growth in young individuals. Thus, aging would be a protecting factor against the fast tumor development, induced by this sleep alteration.

12 Sep 2018

Review discusses complexity of immune-suppressive mechanisms in tumor milieu of cancers

Cancers control immune systems and evade immune detection using mediators consisting of immune checkpoint molecules and cellular systems associated with immune suppression.

29 Jun 2018

Some tumors use two levels of protection against immune system, shows study

In research published today, Babraham Institute researchers have shown that some tumors use not one but two levels of protection against the immune system.

8 Jun 2018

New combination therapy could improve survival in children with high-risk neuroblastoma

Investigators at the Children's Center for Cancer and Blood Diseases at Children's Hospital Los Angeles provide preclinical evidence that the presence of tumor-associated macrophages--a type of immune cell--can negatively affect the response to chemotherapy against neuroblastoma.

25 Apr 2018

Scientists reveal ‘anti-metastatic surveillance’ role of Caveolin-1 protein

A new study conducted at the VIB-KU Leuven Center for Cancer Biology in Belgium has labeled the protein Caveolin-1 as a high-potential pursuit in the fight against cancer.

5 Dec 2017

Researchers identify molecular pathway that causes immune cells to promote cancer

Investigators at the Children's Center for Cancer and Blood Diseases at Children's Hospital Los Angeles have identified new findings about an immune cell - called a tumor-associated macrophage - that promotes cancer instead of fighting it.

21 Sep 2017

Researchers aim to examine therapeutic effect of iPS-ML producing interferon-β on liver cancer

All causes of the most common form of liver cancer, hepatocellular carcinoma, are not yet known, but the risk of getting it is increased by hepatitis B or C, cirrhosis, obesity, diabetes, a buildup of iron in the liver, or a family of toxins called aflatoxins produced by fungi on some types of food.

29 Mar 2017

Bruker Nano Surfaces to hold webinar on label-free FLIM-based metabolite imaging

Bruker Nano Surfaces will hold a webinar on ‘In Vivo Visualization of Stromal Macrophages via Label-free FLIM-based Metabolite Imaging’ on March 29, 2017 at 8am PST / 11am EST / 3pm GMT.

From Bruker Nano Surfaces and Metrology 20 Mar 2017

Research findings show effective way to harness anti-tumor potential of macrophages in cancer therapy

For all the success of a new generation of immunotherapies for cancer, they often leave an entire branch of the immune system's disease-fighting forces untapped.

9 Mar 2017

Study reveals new role for cancer drug in tumor immunology

A drug first designed to prevent cancer cells from multiplying has a second effect: it switches immune cells that turn down the body's attack on tumors back into the kind that amplify it. This is the finding of a study led by researchers from NYU Langone Medical Center and published recently in Cancer Immunology Research.

13 Feb 2017

Targeting Legumain could be promising strategy for treatment of cancer

Legumain (LGMN), or asparaginyl endopeptidase, is a newly identified lysosomal cysteine protease.

3 Jan 2017

Study uncovers mechanism that causes chemo resistance of pancreatic cancer cells

A pioneering University of Liverpool research team have published a study that identifies the mechanism in the human body that causes resistance of pancreatic cancer cells to chemotherapy.

21 Nov 2016

Research identifies potential treatment target for chemoresistant cancer cells

A team of researchers has discovered that chemoresistant lung cancer cells suppress immune functions and strengthen resistance to chemotherapy by producing interleukin-34 (IL-34)—a type of cytokine.

3 Oct 2016

Researchers discover new strategy to boost effectiveness of anti-cancer immune therapy

Researchers at University of California San Diego School of Medicine and Moores Cancer Center have identified a strategy to maximize the effectiveness of anti-cancer immune therapy.

19 Sep 2016

EPFL researchers reprogram TAMs to prevent tumor metastasis

One of the major obstacles with treating cancer is that tumors can conscript the body's immune cells and make them work for them. Researchers at EPFL have now found a way to reclaim the corrupted immune cells, turn them into signals for the immune system to attack the tumor, and even prevent metastasis.

14 Jun 2016

Study shows cancer cell death via necroptosis can drive pancreatic tumor growth

The most aggressive form of pancreatic cancer - often described as one of the hardest malignancies to diagnose and treat -- thrives in the presence of neighboring tumor cells undergoing a particular form of "orchestrated cell death." This is according to a major study recently published in the journal Nature.

25 Apr 2016

Scientists find that lifespan of supportive cells in tumor may control cancer metastasis

Researchers have discovered that eliminating cells thought to aid tumor growth did not slow or halt the growth of cancer tumors. In fact, when the cancer-associated fibroblasts (CAFs), were eliminated after 10 days, the risk of metastasis of the primary tumor to the lungs and bones of mice increased dramatically.

22 Feb 2016

Wistar researchers find potential way for using STAT3 inhibitors to stop cancer progression

Imagine developing a drug designed to inhibit a protein that helps cancer cells proliferate and survive only to find that the drug does not perform very well in the clinic. This was the dilemma faced by scientists researching inhibitors of signal transducer and activator of transcription (STAT3), a protein that controls transcription by the STAT3 gene.

17 Feb 2016

MGH study reveals effects of obesity on pancreatic and breast cancer

Massachusetts General Hospital investigators may have uncovered a novel mechanism behind the ability of obesity to promote cancer progression. In their report published online in the journal Clinical Cancer Research, the research team describes finding an association between obesity and an overabundance of a factor called PlGF (placental growth factor) and that PlGF's binding to its receptor VEGFR-1, which is expressed on immune cells within tumors, promotes tumor progression.

12 Feb 2016