Tumor Necrosis Factor News and Research

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Salt can boost antitumor responses of T cells

Elevated sodium levels in tumors boost T-cell metabolic fitness and cytotoxicity, revealing potential avenues for improving cancer therapies.

13 Sep 2024

The potential benefits of aged black garlic on inflammation and prostate cancer

Researchers investigate the anti-inflammatory and anti-prostate cancer properties of aged black garlic extract.

13 Sep 2024

High linoleic acid intake during pregnancy may harm fetal growth and raise obesity risk

High maternal linoleic acid intake during pregnancy may impact fetal development and increase the risk of obesity and inflammation in offspring. However, more research is needed to fully understand these effects in humans.

10 Sep 2024

Study reveals how sex hormones regulate immune system functions

Findings indicate that testosterone therapy in trans men alters immune system responses, suggesting implications for disease susceptibility and treatment.

6 Sep 2024

Early viral activity plays critical role in long COVID, study suggests

Findings on early viral and immune markers provide insights into the pathogenesis of post-acute sequelae of SARS-CoV-2, informing future research and therapies.

2 Sep 2024

Rare genetic mutation tied to increased risk of tuberculosis

Tuberculosis is a confounding scourge. It's the leading cause of death from infectious disease in the world, and yet it's estimated that those deaths represent perhaps 5% of infections with Mycobacterium tuberculosis (Mtb).

30 Aug 2024

Study reveals key role of A20 protein in controlling inflammation in liver disease

Many individuals worldwide suffer from chronic liver disease (CLD), which poses significant concerns for its tendency to lead to hepatocellular carcinoma or liver failure. CLD is characterized by inflammation and fibrosis.

29 Aug 2024

Unique strain of probiotic bacteria shows potential in combating inflammatory diseases

23 Aug 2024

Risankizumab outperforms ustekinumab in treating moderate-to-severe Crohn’s disease

Researchers compare the therapeutic efficacy of risakizumab and ustekinumab for the treatment of moderate-to-severe Crohn’s disease.

23 Aug 2024

Probiotic offers protection against intestinal damage

There is a critical unmet need to help tighten and maintain a healthy intestinal barrier and treat a leaky gut. Researchers have now found that a unique strain of probiotic bacteria, Bifidobacterium bifidum BB1, enhances intestinal barrier function and protects against penetration of bacteria and various harmful agents in the intestine. The findings, detailed in an article in The American Journal of Pathology, published by Elsevier, can help advance the development of novel, targeted, naturally occurring probiotic therapy for patients with inflammatory bowel disease (IBD) and other inflammatory diseases, such as fatty liver disease or alcoholic liver disease, that are associated with a leaky or disordered intestinal barrier.

23 Aug 2024

The gut barrier plays key role in colorectal cancer prognosis

A new review was published in Oncotarget's Volume 15 on August 14, 2024, entitled, "The gut barrier as a gatekeeper in colorectal cancer treatment."

19 Aug 2024

Novel vaccination strategy shows promise in boosting immunity and controlling influenza spread in pigs

Study demonstrates that a novel prime/boost vaccination protocol using live-attenuated influenza vaccines effectively induces strong immune responses in pigs, offering a promising approach for future influenza vaccination strategies.

13 Aug 2024

Zebrafish model reveals how BCG vaccine triggers immune response in bladder cancer

Using zebrafish "Avatars", an animal model developed by the Cancer Development and Innate Immune Evasion lab at the Champalimaud Foundation (CF), led by Rita Fior, Mayra Martínez-López – a former PhD student at the lab now working at the Universidad de las Américas in Quito, Ecuador – and colleagues studied the initial steps of the Bacillus Calmette-Guérin (BCG) vaccine's action on bladder cancer cells.

8 Aug 2024

Study reveals curcumin’s antidepressant effects in obese type 2 diabetes patients

A randomized clinical trial (RCT) to investigate the effectiveness of curcumin in lowering depression among obese individuals with diabetes mellitus type 2 (T2DM).

30 Jul 2024

Xanthones show promise in diabetes with antioxidant and anti-inflammatory properties

Research reveals xanthones as promising agents in diabetes management, offering antioxidant, anti-inflammatory, and insulin-sensitizing benefits.

29 Jul 2024

Study finds genetic factors key to post-stroke cardiovascular risks

Research identifies genetic and molecular risk factors for cardiovascular outcomes after an initial stroke, uncovering potential therapeutic targets to improve patient prognoses.

28 Jul 2024

Proteomic signatures enhance risk prediction for both common and rare diseases

Researchers have developed sparse prediction models combining plasma proteins and clinical data to predict the 10-year risk of 218 diseases. The study, involving over 41,000 participants, highlights the enhanced predictive power of proteomic signatures.

24 Jul 2024

Tumor Necrosis Factor News and Research

Salt can boost antitumor responses of T cells

The potential benefits of aged black garlic on inflammation and prostate cancer

High linoleic acid intake during pregnancy may harm fetal growth and raise obesity risk

Study reveals how sex hormones regulate immune system functions

Early viral activity plays critical role in long COVID, study suggests

Rare genetic mutation tied to increased risk of tuberculosis

Study reveals key role of A20 protein in controlling inflammation in liver disease

Unique strain of probiotic bacteria shows potential in combating inflammatory diseases

Risankizumab outperforms ustekinumab in treating moderate-to-severe Crohn’s disease

Probiotic offers protection against intestinal damage

The gut barrier plays key role in colorectal cancer prognosis

Novel vaccination strategy shows promise in boosting immunity and controlling influenza spread in pigs

Zebrafish model reveals how BCG vaccine triggers immune response in bladder cancer

Study reveals curcumin’s antidepressant effects in obese type 2 diabetes patients

Xanthones show promise in diabetes with antioxidant and anti-inflammatory properties

Study finds genetic factors key to post-stroke cardiovascular risks

Proteomic signatures enhance risk prediction for both common and rare diseases

Associations between gut microbes and Alzheimer’s disease

Porcine study reveals meurotoxic and pro-inflammatory effects of microplastics on enteric nervous system

Distinct signaling pathway drives the transformation of epithelial cells into aggressive tumors

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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