Tumor Necrosis Factor News and Research

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Common therapy options for psoriasis can help reduce coronary plaque, study shows

Late-breaking clinical science shows common therapy options for psoriasis (PSO)-a chronic inflammatory skin disease-can help reduce coronary plaque. The authors found that not only do the treatments reduce the volume of the plaque, but also the plaque becomes less inflammatory over time harboring fewer characteristics prone to rupture and cause a heart attack.

26 Apr 2018

Anti-TNF medications appear to be safe for use during pregnancy, study shows

Anti-tumor necrosis factor medications are effective in controlling chronic inflammatory diseases, but some physicians recommend that their patients discontinue them during pregnancy.

5 Apr 2018

Levels of inflammatory biomarkers could predict effectiveness of ECT for people with depression

People with major depression that has not been well controlled by medications and who have a biomarker in their blood indicating a higher level of inflammation may benefit more than people with less inflammation from electroconvulsive therapy to ease symptoms of their depression, according to a new UCLA study.

6 Mar 2018

Researchers block common siren call of glioblastoma and metastatic breast cancer

Aggressive cancers like glioblastoma and metastatic breast cancer have in common a siren call that beckons the bone marrow to send along whatever the tumors need to survive and thrive.

23 Jan 2018

LJI study reveals key player that promotes skin inflammation in atopic dermatitis

Severe eczema, also known as atopic dermatitis, is a chronic inflammatory skin condition that is driven by an allergic reaction. In their latest study, researchers at La Jolla Institute reveal an important player that promotes skin inflammation in atopic dermatitis and the characteristic thickening of the skin.

18 Jan 2018

Researchers identify new anti-inflammatory drug target

A new study suggests that parmodulins may provide anti-inflammatory and anti-thrombotic protection to endothelial cells, without interfering with clotting.

16 Jan 2018

New mechanism in cancer cells to disarm attacking immune cells, study reveals

A new study, published in the Journal of Clinical Investigation, identified a substance Gdf-15, which is secreted by pancreatic cancer cells and shields cancerous cells from attack by immune cells known as macrophages.

21 Nov 2017

Study identifies substance released by pancreatic cancer cells to disarm attacking macrophages

A new study by researchers at The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute identifies a substance released by pancreatic cancer cells that protect them from attack by immune cells called macrophages.

21 Nov 2017

Researcher awarded $1.5 million to study role of tumor necrosis factor in IBD

D. Brent Polk, MD, AGAF, an investigator at Children's Hospital Los Angeles, has been awarded $1.5 million by the National Institute of Diabetes and Digestive and Kidney Diseases of the NIH for the study of tumor necrosis factor (TNF) and its role in inflammatory bowel disease (IBD).

20 Nov 2017

People with depressive symptoms before disaster may experience increase in inflammation

People who exhibit even a few depressive symptoms before a major life stressor, such as a disaster, may experience an increase in inflammation -- a major risk factor for heart disease and other negative health conditions -- after the event, according to new research from Rice University.

23 Oct 2017

Pharmacological stimulation of nicotinic receptor could be strategy to treat lung inflammation

It has been amply proven that smoking can cause serious diseases such as emphysema and cancer. A new study, however, shows that pharmacological stimulation of a specific type of nicotinic receptor in cells of the immune system could be a strategy to treat inflammatory lung disease.

20 Oct 2017

Probiotics may become new preventative or therapeutic strategy for IBD-related colon cancer

In an innovative approach to colorectal cancer (CRC) prevention and treatment, scientists are studying ways to replace missing metabolites in patients prone to gut inflammation and CRC.

14 Sep 2017

Sodium channels play important role in keeping tiny lung capillaries from leaking, worsening pneumonia

Sodium channels in the cells that line the tiny capillaries in our lungs play an important role in keeping those capillaries from leaking and potentially worsening conditions like pneumonia, scientists report.

6 Sep 2017

Research reveals underlying reason for intense pain in patients with shingles

Chickenpox is a typical childhood illness. In most cases, it is benign, and the symptoms disappear within ten days. However, its causative agent, Varicella zoster virus (VZV), remains in the organism forever. In some cases, the virus can be reactivated years later, causing a different disease known as herpes zoster, or shingles.

24 Aug 2017

Drug-like molecule appears to interfere with inflammatory response in variety of diseases

A drug-like molecule developed by Duke Health researchers appears to intercede in an inflammatory response that is at the center of a variety of diseases, including some cancers, rheumatoid arthritis and Crohn's disease.

17 Aug 2017

Study: Liver inflammation increases cholesterol levels in people with diabetes

Inflammatory processes in the liver lead to elevated cholesterol levels in people with diabetes, thus promoting subsequent vascular diseases. This is the result of a study by scientists of Helmholtz Zentrum München, Technische Universität München and the Collaborative Research Center SFB 1118 at Heidelberg University Hospital.

14 Aug 2017

Targeting acid metabolite reduces size and spread of breast cancer

It's a metabolite found in essentially all our cells that, like so many things, cancer overexpresses. Now scientists have shown that when they inhibit 20-HETE, it reduces both the size of a breast cancer tumor and its ability to spread to the lungs.

12 Jul 2017

New treatment strategy may destroy difficult-to-treat brain tumors

A new strategy for treating brain tumors may extend or save the lives of patients diagnosed with one of the deadliest forms of cancer, according to a study from UT Southwestern Medical Center.

13 Jun 2017

Research findings provide insight into mechanisms underlying differences in efficacy of anti-TNF drugs

Osaka University-led researchers identified differences in how three drugs bind to tumor necrosis factor, a key mediator of inflammatory disease. The team used sedimentation velocity analytical ultracentrifugation to investigate drug-target binding in a physiological environment and at clinically-relevant concentrations.

15 May 2017

Powerful pain medicine may help reduce vision damage of glaucoma

The tip of our optic nerve is typically the first place injured by glaucoma. Now researchers want to know if the powerful pain medicine (+)-pentazocine can help avoid the damage.

2 May 2017