Tumor Necrosis Factor News and Research

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Reduced NF-κB expression linκed to postradiation oral mucosa vulnerability

The fragility of oral mucosa after radiotherapy for oral squamous cell carcinoma may be due to the inhibition of the DNA transcriptor protein nuclear factor κappa-light-chain-enhancer of activated B cells, show study findings.

6 Sep 2012

Biologic therapies do not increase risk of cancer in patients with rheumatoid arthritis

Biologic therapies developed in the last decade for rheumatoid arthritis are not associated with an increased risk of cancer when compared with traditional treatments for the condition, according to new research from The University of Texas MD Anderson Cancer Center.

6 Sep 2012

Infliximab may offer new hope for people with difficult-to-treat depression

Researchers at Emory University have found that a medication that inhibits inflammation may offer new hope for people with difficult-to-treat depression. The study was published Sept. 3 in the online version of Archives of General Psychiatry.

4 Sep 2012

TNF inhibitors best cardiac option for psoriasis patients

Use of tumor necrosis factor inhibitors is associated with a significantly reduced risk for myocardial infarction in psoriasis patients compared with use of other medications, report researchers.

31 Aug 2012

Tofacitinib shows promise in active ulcerative colitis

Tofacitinib can induce a clinical response in the majority of patients with moderate to severe, active ulcerative colitis, a placebo-controlled trial has shown.

16 Aug 2012

Tofacitinib efficacy suggested for rheumatoid arthritis

The novel oral Janus kinase inhibitor tofacitinib significantly reduces signs and symptoms of rheumatoid arthritis, report two phase III trials published in TheNew England Journal of Medicine.

13 Aug 2012

Pathologist identifies HPV DNA fragments in post-mortem samples after Gardasil vaccination

According to Norma Erickson, President of SaneVax Inc., testimony provided for a coroner's inquest into the death of Jasmine Renata in New Zealand by Dr. Sin Hang Lee, a pathologist on the medical staff at Connecticut's Milford Hospital, revealed the discovery of HPV DNA fragments in post-mortem samples 6 months after Gardasil vaccination.

9 Aug 2012

Adalimumab effective in maintaining remission in pediatric patients with Crohn's disease

Adalimumab (an anti-tumor necrosis factor [TNF] antibody) is effective in maintaining remission in certain pediatric patients with Crohn's disease, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association.

7 Aug 2012

Possible molecular link between circadian rhythm disturbances and increased inflammatory response

Scientists have known for some time that throwing off the body's circadian rhythm can negatively affect body chemistry. In fact, workers whose sleep-wake cycles are disrupted by night shifts are more susceptible to chronic inflammatory diseases such as diabetes, obesity and cancer.

2 Aug 2012

New compound effective at blocking damage to the retina in diabetic retinopathy

Researchers at the University of Michigan Kellogg Eye Center have identified a compound that could interrupt the chain of events that cause damage to the retina in diabetic retinopathy. The finding is significant because it could lead to a novel therapy that targets two mechanisms at the root of the disease: inflammation and the weakening of the blood barrier that protects the retina.

30 Jul 2012

Tumor necrosis factor may play a key role in how light at night leads to depression

Chronic exposure to dim light at night can lead to depressive symptoms in rodents -- but these negative effects can be reversed simply by returning to a standard light-dark cycle, a new study suggests.

24 Jul 2012

Limewater combination therapy can reduce root canal endotoxins

Treating root canals with a combination of chlorhexidine gel and calcium hydroxide results in significant reduction of endotoxins and neutralization of cytotoxic effects compared with the gel plus polymyxin B or saline, report Brazilian researchers.

17 Jul 2012

Altered immune function in relatives of schizophrenia patients

Schizophrenia patients and their unaffected first-degree relatives exhibit immune system alterations compared with mentally healthy individuals, researchers report.

12 Jul 2012

Researchers discover unknown mechanism that promotes growth and spread of cancer

Tiny vesicles released by tumors cells are taken up by healthy immune cells, causing the immune cells to discharge chemicals that foster cancer-cell growth and spread, according to a study by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC - James) and at Children's Hospital in Los Angeles.

11 Jul 2012

Altered immune function in relatives of schizophrenia patients

Schizophrenia patients and their unaffected first-degree relatives exhibit immune system alterations compared with mentally healthy individuals, researchers report.

10 Jul 2012

TNF-α levels linked to lithium response in BD patients

Patients with bipolar disorder who have a poor response to lithium treatment have significantly higher serum levels of tumor necrosis factor-α than those with a good response, researchers report.

10 Jul 2012

Specific cytokine levels altered in BD patients

Levels of certain cytokines differ between bipolar disorder patients and mentally healthy individuals, as well as between manic and euthymic patients with the mood disorder, results from a systematic review and meta-analysis show.

10 Jul 2012

Live zoster vaccine associated with reduced risk of HZ in patients with immune-mediated diseases

Although some have suggested that patients receiving medication for immune-mediated diseases such as rheumatoid arthritis or psoriasis may be at increased risk of herpes zoster (HZ; shingles) shortly after receipt of the vaccine, an analysis that included nearly 20,000 vaccinated Medicare beneficiaries finds that the live zoster vaccine is not associated with an increased risk of HZ shortly after vaccination in patients currently treated with biologics, and that it is associated with a significantly reduced longer-term risk of HZ in patients with an immune-mediated disease, according to a study in the July 4 issue of JAMA.

4 Jul 2012

Shingles vaccine may not increase risk of varicella in people with auto-immune diseases

New research from the University of Alabama at Birmingham casts doubt on the long-standing belief that the vaccine for shingles should not be given to patients taking biologics for auto-immune diseases such as rheumatoid arthritis.

4 Jul 2012

Platelet activation linked to osteoporosis

Elderly, postmenopausal women with osteoporosis have elevated platelet volumes, report researchers.

2 Jul 2012

Tumor Necrosis Factor News and Research

Reduced NF-κB expression linκed to postradiation oral mucosa vulnerability

Biologic therapies do not increase risk of cancer in patients with rheumatoid arthritis

Infliximab may offer new hope for people with difficult-to-treat depression

TNF inhibitors best cardiac option for psoriasis patients

Tofacitinib shows promise in active ulcerative colitis

Tofacitinib efficacy suggested for rheumatoid arthritis

Pathologist identifies HPV DNA fragments in post-mortem samples after Gardasil vaccination

Adalimumab effective in maintaining remission in pediatric patients with Crohn's disease

Possible molecular link between circadian rhythm disturbances and increased inflammatory response

New compound effective at blocking damage to the retina in diabetic retinopathy

Tumor necrosis factor may play a key role in how light at night leads to depression

Limewater combination therapy can reduce root canal endotoxins

Altered immune function in relatives of schizophrenia patients

Researchers discover unknown mechanism that promotes growth and spread of cancer

Altered immune function in relatives of schizophrenia patients

TNF-α levels linked to lithium response in BD patients

Specific cytokine levels altered in BD patients

Live zoster vaccine associated with reduced risk of HZ in patients with immune-mediated diseases

Shingles vaccine may not increase risk of varicella in people with auto-immune diseases

Platelet activation linked to osteoporosis

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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