Ubiquitin News and Research

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Ubiquitin is a small regulatory protein that has been found in almost all cells (''ubiquitously'') with nuclei (eukaryotes). It directs proteins to recycling and other functions.

Scientists link cell's protein recycling systems

Many age-related neurological diseases are associated with defective proteins accumulating in nerve cells, suggesting that the cell's normal disposal mechanisms are not operating correctly.

17 Jun 2007

25,000 genes that have clocks!

A chemical signal acts as time clock in the expression of genes controlled by a master gene called a coactivator, said Baylor College of Medicine researchers in a report that appears in the journal Cell today.

17 Jun 2007

New candidate breast-cancer susceptibility gene

Researchers at the Abramson Family Cancer Research Institute of the University of Pennsylvania and the Dana-Farber Cancer Institute describe in this week's issue of Science a new candidate breast-cancer susceptibility gene.

28 May 2007

New understanding of ubiquitylation

It turns out there's more than one way to skin a gene. New research from Rockefeller University suggests that two closely related DNA unpackaging mechanisms may not work the way scientists thought.

10 May 2007

Disease associated prion protein oligomers inhibit the 26S proteasome

The rogue prion proteins responsible for diseases like BSE and vCJD can destroy brain cells by blocking the protein recycling process that helps keep cells healthy.

27 Apr 2007

UNC-45 protein critical to proper formation of muscles

Proper formation of the proteins that power heart and skeletal muscle seems to rely on a precise concentration of a "chaperone" protein known as UNC-45, according to a new study.

24 Apr 2007

How auxin regulates TIR1 in plants provides clues to new treatments for human diseases

For the first time, scientists from the University of Washington School of Medicine, Indiana University Bloomington and the University of Cambridge have determined how a plant hormone -- auxin -- interacts with its hormone receptor, called TIR1.

5 Apr 2007

Recognition for cancer researchers

World-class cancer researchers whose science has significantly contributed to progress in the fight against cancer will be recognized April 14-18, 2007, by the American Association for Cancer Research (AACR) at its 2007 Annual Meeting in Los Angeles, Calif.

3 Apr 2007

New drug target for herpes viruses

Scientists in the lab of Whitehead Institute Member Hidde Ploegh and the Harvard University lab of Rachelle Gaudet have solved the complex structure of a recently discovered protein that is found in a wide range of herpes viruses. This protein may prove to be a potential drug target.

11 Mar 2007

New drug target for herpes viruses

11 Mar 2007

Kaposi's sarcoma-associated herpesvirus tricks cells to become tumors

Researchers at the University of Pennsylvania School of Medicine have discovered how the Kaposi's sarcoma-associated herpesvirus (KSHV) subverts a normal cell process in order to promote tumor growth.

8 Nov 2006

Protection for nerve cells - eating up defective proteins

Nerve cells in the Central Nervous System can defend against and recover from damage by proteinlike clusters which are associated with neurodegenerative diseases such as Huntington's Chorea.

13 Sep 2006

Molecular chaperones protect cells

Falsely folded proteins and their aggregations in neurons are considered to be the cause of neurodegenerative diseases, among them Chorea Huntington.

13 Sep 2006

Boosting enzyme may reverse Alzheimer's

New research by scientists at Columbia University suggests that boosting the function of a certain enzyme may provide a promising strategy for battling Alzheimer's disease, and possibly reversing its effects.

28 Aug 2006

Researchers find cause of frontotemporal dementia

Frontotemporal Dementia (FTD) is the second major form of dementia.

17 Jul 2006

Scientists discover molecular security mechanism for keeping gene mutations in check

Everyone knows mutations - genetic mistakes in DNA, the material of heredity - are bad: The more mutations in the cell's DNA, the higher the risk of cancer developing.

8 May 2006

Important new global mechanism for gene repression

Most of the time in most cells of the body, the great majority of genes are silenced, locked away within the compacted but orderly material that makes up chromosomes.

18 Apr 2006

New information about the molecular pathway used by ubiquitin

Because ubiquitin plays a key role in cell survival, scientists have already begun to develop drugs to target parts of the ubiquitin pathway in treating diseases such as cancer.

28 Mar 2006

New understanding of Mediterranean spotted fever

New research by a team of scientists in France and the United States has identified both the bacterial and host receptor proteins that enable Rickettsia conorii, the Mediterranean spotted fever pathogen, to enter cells.

15 Dec 2005

Preventing muscle wasting with a leucine-rich diet

Muscle in adults is constantly being built and broken down. As young adults we keep the two processes in balance, but when we age breakdown starts to win. However, adding the amino acid leucine to the diet of old individuals can set things straight again.

5 Dec 2005