Ubiquitin News and Research

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Ubiquitin is a small regulatory protein that has been found in almost all cells (''ubiquitously'') with nuclei (eukaryotes). It directs proteins to recycling and other functions.

Researchers elucidate new mechanism for controlling DNA methylation in cells

Why normal cells turn into cancer cells One of the factors is deeply related to the failure of the cell differentiation mechanism called DNA methylation.

17 Mar 2020

Study unravels molecular mechanism behind autoimmune and inflammatory diseases

A study by the research team of Prof. Geert van Loo (VIB-UGent Center for Inflammation Research) has unraveled a critical molecular mechanism behind autoimmune and inflammatory diseases such as rheumatoid arthritis, Crohn's disease, and psoriasis.

17 Mar 2020

Researchers find way to inactivate cancer protein with the help of another protein

Squamous cell carcinoma is a very unusual type of cancer. They occur in many tissues – for example in the lungs, esophagus, pancreas, throat and pharynx, and on the skin.

10 Mar 2020

New study expands the knowledge on tumor-suppressor role of HERC proteins

The RAF protein could be a therapeutical target to treat the tumor growth in regulated pathways by the p38 protein, according to a new study published in the journal Scientific Reports by a team of experts of the Faculty of Medicine and Health Sciences of the University of Barcelona and the Bellvitge Institute for Biomedical Research.

20 Feb 2020

Study reveals underlying mechanism for life-threatening cardiac arrhythmias

Low oxygen levels in the heart have long been known to produce life-threatening arrhythmias, even sudden death. Until now, it was not clear how.

18 Feb 2020

Siah2 Gene Control could Help Treat Melanomas More Effectively

To develop improved cancer immunotherapies, it is essential to understand how cancers shut down the natural immune response to foreign antigens. This current study demonstrates how mice lacking the Siah2 gene, fail to develop BRAF-mutation carrying melanoma from the corresponding cells, completely rejecting them. This could help in boosting the anticancer effect of existing specific immune checkpoint inhibitors, such as anti-PD-1 drugs.

10 Jan 2020

New blood test can help identify elderly concussion patients with brain tissue damage

Novel research shows that a blood test can differentiate elderly concussion patients with brain tissue damage from those without it. This finding, published in the special brain health collection of AACC's The Journal of Applied Laboratory Medicine, could help ensure that elderly patients with severe concussions receive crucial treatment for their injuries.

6 Jan 2020

Researchers identify protein that is key for successful viral DNA uncoating

Viruses have been part of animals and humans for eons. When viruses invade a cell, they can infiltrate the nucleus with their genome and become part of the genome of the infected organism. Viruses transfer their genes between various organisms, as well as between tissues containing well differentiated cells inside a living creature. But how they uncoat their well-packed genes and release them to cause infection is largely unknown.

17 Dec 2019

Study reveals role of corpora amylacea in expelling brain waste substances

An article published in Proceedings of the National Academy of Sciences describes a new pathway in the central nervous system to expel waste substances from the brain through the creation of corpora amylacea, aggregates formed by glucose polymers amassing waste products.

4 Dec 2019

Scientists sheds light on small protein and its role in immune response

The immune system is the body’s defense against disease-causing pathogens. It works by warding off disease and potentially-damaging foreign bodies. Now, a team of researchers have developed a new method to shed light on the basic defense mechanism of the immune system.

27 Nov 2019

New strategy could help cells get rid of disease-related debris

Tohoku University researchers have developed a strategy that could help cells get rid of disease-related debris. Further research could lead to treatments for neurodegenerative and metabolic diseases, Down syndrome, and maybe even aging-related diseases.

27 Nov 2019

Discovery may provide clues for treatment of autism and schizophrenia

Researchers at the Case Western Reserve University School of Medicine have identified that a gene critical to clearing up unnecessary proteins plays a role in brain development and contributes to the development of autism spectrum disorders and schizophrenia.

25 Nov 2019

Discovery may lead to possible treatments for autism spectrum disorders, schizophrenia

25 Nov 2019

Study: MIB2 improves inflammation by degrading CYLD enzyme

The tumor suppressor CYLD lysine 63 deubiquitinase (CYLD) is a deubiquitinating enzyme that suppresses polyubiquitin-dependent signaling pathways, including the proinflammatory and cell growth-promoting NF-κB pathway.

30 Oct 2019

Researchers obtain 3D structural snapshots of key regulator of cell biology

Some of the greatest insights into cancer and how to treat it come when basic scientists and cancer biologists and clinicians collaborate.

17 Oct 2019

€7.6 million ERC Synergy grant to support research on molecular mechanisms of viral infection

The interdisciplinary team wants to investigate the molecular mechanisms of viral infection, which will contribute to fundamental knowledge about cellular regulation and new concepts for broad-spectrum anti-viral therapy. The funding amounts to 7.6 million euros.

11 Oct 2019