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VEGF is a substance made by cells that stimulates new blood vessel formation. Also called vascular endothelial growth factor.

Study identifies signaling pathway essential for growth of new blood vessels

A new study led by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) identifies a signaling pathway that is essential for angiogenesis, the growth of new blood vessels from pre-existing vessels.

23 Nov 2017

Absence of VEGF-A in cancer-killing T cells accelerates tumor development

Contrary to what was previously believed, the immune system's cancer-killing T cells are more effective in a tumour's anoxic environment when they have access to growth factor VEGF-A.

13 Nov 2017

Largest clinical specialty database powers studies that yield key insights

The American Academy of Ophthalmology today announced key milestones and clinical insights from studies powered by its clinical database.

13 Nov 2017

Study identifies protein that plays crucial role in diabetic retinopathy

For millions of Americans, their world is dissolving into an unrecognizable blur. Diabetic retinopathy is an eye disease affecting one-third of the estimated 30 million Americans who struggle with diabetes. As the patients' vision slowly fades, it never recovers and few treatments are available.

24 Oct 2017

Scientists identify potential treatment target for diabetic retinopathy

In oxygen-compromising conditions like diabetes, the body grows new blood vessels to help, but the result is often leaky, dysfunctional vessels that make bad matters worse.

10 Oct 2017

Study sheds light on the mechanism of lung damage in premature babies

The lungs are one of the last organs to undergo full maturation in a baby's body. Children that are born very prematurely do not have fully developed lungs, and are therefore more susceptible to associated complications.

30 Sep 2017

Biomaterial-mediated growth factor delivery can restore perfusion of blood vessels in animal models

Ischemia is a serious medical condition in which the flow of blood and delivery of oxygen to tissues is restricted, thus resulting in pain, weakness, and more seriously, tissue and organ damage. Ischemia in muscle tissue, most commonly as a result of atherosclerosis, leads to life-threatening diseases like coronary artery disease and stroke, but also to chronic peripheral artery disease (PAD).

26 Sep 2017

Heidelberg researchers gain new insights into formation of blood vessels

New insights into the development of the vascular system: researchers in the team of Dr Carmen Ruiz de Almodóvar of the Heidelberg University Biochemistry Center have discovered a crucial biological step that regulates the formation of blood vessels.

15 Sep 2017

MGH researchers identify potential strategy for improving efficacy of angiogenesis inhibitors

A Massachusetts General Hospital research team has identified a potential strategy for improving the efficacy of angiogenesis inhibitors, drugs that help fight cancer by blocking the formation of new blood vessels.

13 Sep 2017

Study shows previously unknown dimension of lymphangiogenesis during worm infection

Lymph nodes are small, kidney-shaped organs found throughout the body. Full of immune cells, their function is to clear out foreign objects and support the immune system.

28 Aug 2017

Researchers present novel gene-editing technique to prevent retinal angiogenesis

A research team from the Schepens Eye Research Institute of Massachusetts Eye and Ear has successfully prevented mice from developing angiogenesis of the retina--the sensory tissue at the back of the eye--using gene-editing techniques with CRISPR-Cas9.

25 Jul 2017

MGH researchers identify novel mechanism behind resistance to angiogenesis inhibitors

A Massachusetts General Hospital research team has identified a novel mechanism behind resistance to angiogenesis inhibitors - drugs that fight cancer by suppressing the formation of new blood vessels.

14 Jul 2017

Two-test combination accurately identifies benign pancreatic lesions

When performed in tandem, two molecular biology laboratory tests distinguish, with near certainty, pancreatic lesions that mimic early signs of cancer but are completely benign.

23 Jun 2017

Researchers bioengineer human liver tissues that mimic natural development

An international team of researchers bioengineering human liver tissues uncovered previously unknown networks of genetic-molecular crosstalk that control the organ's developmental processes – greatly advancing efforts to generate healthy and usable human liver tissue from human pluripotent stem cells.

15 Jun 2017

Single bout of exercise can have significant positive behavioral and cognitive effects

In a new review of the effects of acute exercise published in Brain Plasticity, researchers not only summarize the behavioral and cognitive effects of a single bout of exercise, but also summarize data from a large number of neurophysiological and neurochemical studies in both humans and animals showing the wide range of brain changes that result from a single session of physical exercise.

12 Jun 2017

IBS scientists uncover biological pathway that contributes to thyroid disorder

A team led by KOH Gou Young, director of the Center for Vascular Research, within the Institute for Basic Science, in collaboration with Chungnam National University, clarified the molecular mechanism to explain how the thyroid and surrounding vascular system change in the most common form of hyperthyroidism.

18 May 2017

Experimental gene therapy proven safe for preserving vision of people with AMD

In a small and preliminary clinical trial, Johns Hopkins researchers and their collaborators have shown that an experimental gene therapy that uses viruses to introduce a therapeutic gene into the eye is safe and that it may be effective in preserving the vision of people with wet age-related macular degeneration.

17 May 2017

Large source of real-time data provides insight into treatment for vision-threatening condition

For most people, being nearsighted is a nuisance, easily treated with a prescription for glasses or contact lenses. But some experience a complication that can cause permanent blindness.

11 May 2017

Research illuminates how primary colorectal tumors contribute to premetastatic 'niche' formation

Primary colorectal tumors secrete VEGF-A, inducing CXCL1 and CXCR2-positive myeloid-derived suppressor cell (MDSC) recruitment at distant sites and establishing niches for future metastases, report Medical University of South Carolina investigators in an article published online ahead of print on April 28, 2017 by Cancer Research.

10 May 2017

Two widely used drugs show effectiveness in treating patients with CRVO-associated macular edema

Monthly eye injections of Avastin (bevacizumab) are as effective as the more expensive drug Eylea (aflibercept) for the treatment of central retinal vein occlusion, according to a clinical trial funded by the National Eye Institute, part of the National Institutes of Health.