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Sildenafil citrate, sold as Viagra, Revatio and under various other trade names, is a drug used to treat erectile dysfunction and pulmonary arterial hypertension (PAH). It was developed and is being marketed by the pharmaceutical company Pfizer. It acts by inhibiting cGMP specific phosphodiesterase type 5, an enzyme that regulates blood flow in the penis. Since becoming available in 1998, sildenafil has been the prime treatment for erectile dysfunction; its primary competitors on the market are tadalafil (Cialis) and vardenafil (Levitra). It is frequently called the 'blue pill'.

Managing the rise in STIs among older adults

A new research review presented at a pre-congress day for this year's European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2024, Barcelona, 27-30 April) will look at how to manage the rise in sexually transmitted infections (STIs) in older people, such as gonorrhea, syphilis, and genital warts.

27 Mar 2024

Men using erectile dysfunction drugs less likely to develop Alzheimer's disease

Drugs commonly used to treat erectile dysfunction may reduce the risk of Alzheimer's disease, finds a new study led by UCL researchers.

9 Feb 2024

Study warns of increased risks in heart patients using ED drugs with nitrates

A Swedish study reveals higher risks for men with cardiovascular disease using erectile dysfunction drugs (PDE5 inhibitors) alongside nitrate medication, potentially increasing morbidity and mortality.

15 Jan 2024

Psychological causes and treatments for erectile dysfunction often overlooked, researchers say

Personality traits and mental health problems are among the factors linked to erectile dysfunction (ED), a condition that affects up to 80% of men over the age of 60.

27 Sep 2023

Study explores the use of existing medicines to revolutionize cancer treatment

In a recent study published in the journal of Genes & Diseases, Research team led by Lu explores the potential for the use of FDA-approved hypertension and EMA-approved cough medicines to revolutionize cancer treatment.

10 Aug 2023

Low sexual satisfaction in mid-life may signal future cognitive decline

Low sexual satisfaction in middle age may serve as an early warning sign for future cognitive decline, according to a new study led by Penn State researchers.

30 May 2023

High-dose drug for erectile dysfunction improves long-term blood sugar levels in diabetes patients

A small group of patients with type 2 diabetes significantly improved their long-term blood sugar levels when treated with high-dose tadalafil, a medication used to treat erectile dysfunction.

5 May 2023

Despite pharma claims, illicit drug shipments to us aren’t full of opioids. It’s generic Viagra.

For years, the FDA has defended its efforts to intercept prescription drugs coming from abroad by mail as necessary to keep out dangerous opioids, including fentanyl.

6 Mar 2023

One Texas judge will decide fate of abortion pill used by millions of American women

Federal judges in Texas have delivered time and again for abortion opponents.

24 Feb 2023

Disruptive symptoms and potential complications of enlarged prostate

Half of all men develop enlarged prostates -; also called benign prostatic hyperplasia -; by the time they're 50 years old. The walnut-sized gland never stops slowly growing.

22 Feb 2023

Mark Cuban has been taking on the drug industry. But which one?

When billionaire Mark Cuban announced his attack on the pharmaceutical industry and its high-priced drugs in January 2021, it was met with cheers.

17 Feb 2023

Viagra and Cialis may not be suitable candidates for treating dementia, NIH DREAM study shows

Results from the National Institutes of Health's Drug Repurposing for Effective Alzheimer's Medicines (DREAM) study show that sildenafil (Viagra) and tadalafil (Cialis) may not be suitable candidates for treating dementia.

4 Oct 2022

Patients with COVID-19 pneumonitis and moderate to severe ARDS treated with sildenafil

A new study published in the British Journal of Anaesthesia aimed to determine whether sildenafil could improve gaseous exchange in patients with COVID-19 ARDS with pulmonary hypertension, RV dysfunction, or both.

17 May 2022

Why cheap, older drugs that might treat covid never get out of the lab

In March 2020, Dr. Joseph Vinetz left the contemplative world of his Yale University infectious-disease laboratory and plunged into the covid ward at Yale New Haven Hospital, joining an army of health care workers who struggled to treat the deadly viral disease.

19 Apr 2022

Generic version of Viagra could be the long-waited remedy for dogs with megaesophagus

Sildenafil, the generic version of the drug known as Viagra, could be the long-waited remedy for a group of dogs with a rare disorder called megaesophagus.

21 Feb 2022

Study examines whether viagra-like drug may be effective in treating vascular dementia

A new study, published today in Alzheimer's & Dementia, tested whether tadalafil, a drug closely related to Viagra, may be effective in treating people with vascular dementia.

9 Feb 2022

Existing drug reduces obesity and fatty liver in mice without changes in food intake or daily activity

Researchers at Johns Hopkins Medicine have found that a drug first developed to treat Alzheimer's disease, schizophrenia and sickle cell disease reduces obesity and fatty liver in mice and improves their heart function — without changes in food intake or daily activity.

7 Oct 2021

Topical drug regenerates, restores function of erectile nerves damaged by radical prostatectomy

Researchers at Albert Einstein College of Medicine have developed a topical drug that regenerates and restores the function of erectile nerves damaged by radical prostatectomy, the most common treatment for localized prostate cancer.

19 Apr 2021

Study examines the impact of Viagra drug advertising on birth rates

Many marketing studies have examined the impact of direct-to-consumer advertising of pharmaceuticals on sales and market shares. But in a new study, a researcher from The University of Texas at Dallas wanted to know whether drug advertising might have some unintended, population-level health consequences.

1 Oct 2020

Potency-enhancing drugs show ability to improve prognosis in patients with colorectal cancer

A new study from Lund University and Region Skåne in Sweden indicates that potency-enhancing PDE5 inhibitor drugs have an anti-cancer potential with the ability to improve the prognosis in patients with colorectal cancer.

17 Aug 2020