White Blood Cell News and Research

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Lenalidomide following stem cell transplant can halt progression of blood cancer

Multiple myeloma patients are better equipped to halt progression of this blood cancer if treated with lenalidomide, or Revlimid-, following a stem cell transplant, according to a study co-authored by a physician with the Oregon Health & Science University Knight Cancer Institute.

17 May 2012

Quasi-experimental data supports argument that air pollution may be a global risk factor for CVD

During the 2008 Beijing Olympics, changes in air pollution were associated with changes in biomarkers of systemic inflammation and thrombosis (formation of blood clot) as well as measures of cardiovascular physiology in healthy young persons, according to a study in the May 16 issue of JAMA, a theme issue on Global Health.

16 May 2012

Researchers map processes that power health benefits of omega-3 fatty acids

For the first time, researchers at the University of California, San Diego have peered inside a living mouse cell and mapped the processes that power the celebrated health benefits of omega-3 fatty acids. More profoundly, they say their findings suggest it may be possible to manipulate these processes to short-circuit inflammation before it begins, or at least help to resolve inflammation before it becomes detrimental.

16 May 2012

New insights into how body's innate immunity is triggered to create effective immune response

Singapore scientists from Bioprocessing Technology Institute (BTI) under the Agency of Science, Technology and Research (A*STAR) have for the first time, identified the molecular 'switch' that directly triggers the body's first line of defence against pathogens, more accurately known as the body's "innate immunity".

11 May 2012

Healthy newborns should not be over-protected against natural exposure of gut flora

Infants whose gut is colonised by E. coli bacteria early in life have a higher number of memory B cells in their blood, reveals a study of infants carried out at the Sahlgrenska Academy at the University of Gothenburg, Sweden.

7 May 2012

A test to predict breast cancer many years before the disease is diagnosed

Ultimately the findings, in the journal Cancer Research, could lead to a simple blood test to screen women, they say. The test looks for how genes are altered by environmental factors like alcohol and hormones - a process known as epigenetics. One in five women is thought to have such a genetic “switch” that doubles breast cancer risk say researchers.

3 May 2012

Study sheds new light on common food poisoning bug

BBSRC-funded researchers at Cambridge University have shed new light on a common food poisoning bug. Using real-time video microscopy, coupled with mathematical modelling, they have changed our assumptions about Salmonella and how it infects human cells.

26 Apr 2012

New PBC tool for prioritizing laboratory-based CD-4 cell count testing

One of the major problems that has slowed progress toward universal access to life-saving antiretroviral therapy (ART) to treat AIDS in developing nations has been limited availability of laboratories and trained medical staff to conduct blood tests of immune system CD-4 T-cell levels that indicate when to start ART.

18 Apr 2012

Caring for wife with breast cancer can affect men's health

Caring for a wife with breast cancer can have a measurable negative effect on men's health, even years after the cancer diagnosis and completion of treatment, according to recent research.

17 Apr 2012

Coronary stents do not increase risk of heart attack, death in people with metal allergies

Cardiologists have long grappled with how to best manage patients with coronary artery disease who report skin hypersensitivity to nickel or other metal components found in stents -- small tubes placed in narrowed or weakened arteries to help improve blood flow to the heart. But new Mayo Clinic research, published in the April 16, 2012, issue of Circulation: Cardiovascular Interventions, may help allay these concerns.

17 Apr 2012

Two related enzymes play a key role in development of T-ALL

Columbia University Medical Center (CUMC) scientists have demonstrated that two related enzymes - phosphoinositide-3 kinase (PI3K) gamma and delta - play a key role in the development of T-cell acute lymphoblastic leukemia (T-ALL), a highly aggressive childhood leukemia that is difficult to treat.

17 Apr 2012

ALL induction treatment failure should not be an automatic indication for bone marrow transplant

International study that included St. Jude Children's Research Hospital reports some young acute lymphoblastic leukemia patients who fail induction therapy can achieve high cure rates without bone marrow transplantation.

12 Apr 2012

Blocking PRC2 protein may help protect against AML

Scientists at Cold Spring Harbor Laboratory have identified a candidate drug target for treating acute myeloid leukemia, a white blood cell cancer that proliferates out of control in the bone marrow.

2 Apr 2012

Top-line results from Shire's SPD476 phase 3 trial on diverticulitis

Shire plc, the global specialty biopharmaceutical company, today announced top-line results of the PREVENT2 trial, a phase 3 investigational study of once-daily SPD476, MMX mesalamine in patients with a history of diverticulitis.

31 Mar 2012

Commensal bacteria may play an important role in influencing and controlling allergic inflammation

When poet Walt Whitman wrote that we "contain multitudes," he was speaking metaphorically, but he was correct in the literal sense. Every human being carries over 100 trillion individual bacterial cells within the intestine -- ten times more cells than comprise the body itself.

26 Mar 2012

Results from AspenBio Pharma's AppyScore trial on appendicitis to be presented at SAEM meeting

The results from AspenBio Pharma's 503-patient pilot study of AppyScore will be presented from the podium the upcoming West Region meeting of the Society for Academic Emergency Medicine (SAEM) being held in Las Vegas, March 16-17.

17 Mar 2012

Addition of inflammatory biomarkers to clinical variables improve mortality prediction in COPD

The addition of changes in inflammatory biomarkers to established clinical variables improves the prediction of mortality in patients with chronic obstructive pulmonary disease (COPD), according to a new study.

16 Mar 2012

Study addresses how human body controls gamma-herpesviruses

New research from the Trudeau Institute addresses how the human body controls gamma-herpesviruses, a class of viruses thought to cause a variety of cancers. The study, carried out in the laboratory of Dr. Marcia Blackman, awaits publication in The Journal of Immunology.

13 Mar 2012

New inexpensive medical sensor may simplify diagnosis of diseases

An inexpensive new medical sensor has the potential to simplify the diagnosis of diseases ranging from life-threatening immune deficiencies to the common cold, according to its inventors at the Stanford University School of Medicine.

8 Mar 2012

New HS44 molecule inhibits lung metastasis

One type of white blood cell, the Natural Killer T Cells, fights against infections and tumours by freeing cytokine proteins which activate the body's immune response and destroy infected or malignant cells. To do so they must receive an activation signal. Specific receptors located on their surface act as switches: they activate the lymphocyte in presence of an antigen, a molecule which triggers alarm signals.

2 Mar 2012

White Blood Cell News and Research

Lenalidomide following stem cell transplant can halt progression of blood cancer

Quasi-experimental data supports argument that air pollution may be a global risk factor for CVD

Researchers map processes that power health benefits of omega-3 fatty acids

New insights into how body's innate immunity is triggered to create effective immune response

Healthy newborns should not be over-protected against natural exposure of gut flora

A test to predict breast cancer many years before the disease is diagnosed

Study sheds new light on common food poisoning bug

New PBC tool for prioritizing laboratory-based CD-4 cell count testing

Caring for wife with breast cancer can affect men's health

Coronary stents do not increase risk of heart attack, death in people with metal allergies

Two related enzymes play a key role in development of T-ALL

ALL induction treatment failure should not be an automatic indication for bone marrow transplant

Blocking PRC2 protein may help protect against AML

Top-line results from Shire's SPD476 phase 3 trial on diverticulitis

Commensal bacteria may play an important role in influencing and controlling allergic inflammation

Results from AspenBio Pharma's AppyScore trial on appendicitis to be presented at SAEM meeting

Addition of inflammatory biomarkers to clinical variables improve mortality prediction in COPD

Study addresses how human body controls gamma-herpesviruses

New inexpensive medical sensor may simplify diagnosis of diseases

New HS44 molecule inhibits lung metastasis

Immunology eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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